Anatomical structures, cell types, and biomarkers of the healthy human blood vasculature
Abstract More than 150 scientists from 17 consortia are collaborating on an international project to build a Human Reference Atlas, which maps all 37 trillion cells in the healthy adult human body. The initial release of this atlas provided hierarchical lists of the anatomical structures, cell types...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-07-01
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| Series: | Scientific Data |
| Online Access: | https://doi.org/10.1038/s41597-023-02018-0 |
| _version_ | 1827895384415928320 |
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| author | Avinash Boppana Sujin Lee Rajeev Malhotra Marc Halushka Katherine S Gustilo Ellen M. Quardokus Bruce W. Herr Katy Börner Griffin M. Weber |
| author_facet | Avinash Boppana Sujin Lee Rajeev Malhotra Marc Halushka Katherine S Gustilo Ellen M. Quardokus Bruce W. Herr Katy Börner Griffin M. Weber |
| author_sort | Avinash Boppana |
| collection | DOAJ |
| description | Abstract More than 150 scientists from 17 consortia are collaborating on an international project to build a Human Reference Atlas, which maps all 37 trillion cells in the healthy adult human body. The initial release of this atlas provided hierarchical lists of the anatomical structures, cell types, and biomarkers in 11 organs. Here, we describe the methods we used as part of this initiative to build the first open, computer-readable, and comprehensive database of the adult human blood vasculature, called the Human Reference Atlas-Vasculature Common Coordinate Framework (HRA-VCCF). It includes 993 vessels and their branching connections, 10 cell types, and 10 biomarkers. With this paper we are releasing additional details on vessel types and subtypes, branching sequence, anastomoses, portal systems, microvasculature, functional tissue units, mappings to regions vessels supply or drain, geometric properties of vessels, and links to 3D reference objects. Future versions will add variants and connections to the lymph vasculature; and, it will iteratively expand and improve the database as additional experimental data become available through the participating consortia. |
| first_indexed | 2024-03-12T22:20:12Z |
| format | Article |
| id | doaj.art-d57010fab4574f028fd543f65bc60d21 |
| institution | Directory Open Access Journal |
| issn | 2052-4463 |
| language | English |
| last_indexed | 2024-03-12T22:20:12Z |
| publishDate | 2023-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Data |
| spelling | doaj.art-d57010fab4574f028fd543f65bc60d212023-07-23T11:06:10ZengNature PortfolioScientific Data2052-44632023-07-0110111110.1038/s41597-023-02018-0Anatomical structures, cell types, and biomarkers of the healthy human blood vasculatureAvinash Boppana0Sujin Lee1Rajeev Malhotra2Marc Halushka3Katherine S Gustilo4Ellen M. Quardokus5Bruce W. Herr6Katy Börner7Griffin M. Weber8RevelaDepartment of Surgery, Massachusetts General HospitalDepartment of Medicine, Massachusetts General HospitalDepartment of Pathology, Johns Hopkins MedicineDepartment of Intelligent Systems Engineering, Luddy School of Informatics, Computing, and Engineering, Indiana UniversityDepartment of Intelligent Systems Engineering, Luddy School of Informatics, Computing, and Engineering, Indiana UniversityDepartment of Intelligent Systems Engineering, Luddy School of Informatics, Computing, and Engineering, Indiana UniversityDepartment of Intelligent Systems Engineering, Luddy School of Informatics, Computing, and Engineering, Indiana UniversityDepartment of Biomedical Informatics, Harvard Medical SchoolAbstract More than 150 scientists from 17 consortia are collaborating on an international project to build a Human Reference Atlas, which maps all 37 trillion cells in the healthy adult human body. The initial release of this atlas provided hierarchical lists of the anatomical structures, cell types, and biomarkers in 11 organs. Here, we describe the methods we used as part of this initiative to build the first open, computer-readable, and comprehensive database of the adult human blood vasculature, called the Human Reference Atlas-Vasculature Common Coordinate Framework (HRA-VCCF). It includes 993 vessels and their branching connections, 10 cell types, and 10 biomarkers. With this paper we are releasing additional details on vessel types and subtypes, branching sequence, anastomoses, portal systems, microvasculature, functional tissue units, mappings to regions vessels supply or drain, geometric properties of vessels, and links to 3D reference objects. Future versions will add variants and connections to the lymph vasculature; and, it will iteratively expand and improve the database as additional experimental data become available through the participating consortia.https://doi.org/10.1038/s41597-023-02018-0 |
| spellingShingle | Avinash Boppana Sujin Lee Rajeev Malhotra Marc Halushka Katherine S Gustilo Ellen M. Quardokus Bruce W. Herr Katy Börner Griffin M. Weber Anatomical structures, cell types, and biomarkers of the healthy human blood vasculature Scientific Data |
| title | Anatomical structures, cell types, and biomarkers of the healthy human blood vasculature |
| title_full | Anatomical structures, cell types, and biomarkers of the healthy human blood vasculature |
| title_fullStr | Anatomical structures, cell types, and biomarkers of the healthy human blood vasculature |
| title_full_unstemmed | Anatomical structures, cell types, and biomarkers of the healthy human blood vasculature |
| title_short | Anatomical structures, cell types, and biomarkers of the healthy human blood vasculature |
| title_sort | anatomical structures cell types and biomarkers of the healthy human blood vasculature |
| url | https://doi.org/10.1038/s41597-023-02018-0 |
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