The deubiquitinating enzyme MINDY2 promotes pancreatic cancer proliferation and metastasis by stabilizing ACTN4 expression and activating the PI3K/AKT/mTOR signaling pathway

The deubiquitinating enzyme MINDY2 promotes pancreatic cancer proliferation and metastasis by stabilizing ACTN4 expression and activating the PI3K/AKT/mTOR signaling pathway

The pathogenic mechanisms of pancreatic cancer (PC) are still not fully understood. Ubiquitination modifications have a crucial role in tumorigenesis and progression. Yet, the role of MINDY2, a member of the motif interacting with Ub-containing novel DUB family (MINDY), as a newly identified deubiqu...

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Bibliographic Details
Main Authors: Peng Liu, Songbai Liu, Changhao Zhu, Yongning Li, Ying Li, Xiaobin Fei, Junyi Hou, Xing Wang, Yaozhen Pan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Oncology
Subjects:
pancreatic cancer
MINDY2
deubiquitinating enzyme
ACTN4
PI3K/AKT/mTOR
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1169833/full

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