Inhibition and potential treatment of colorectal cancer by natural compounds via various signaling pathways
Colorectal cancer (CRC) is a common type of malignant digestive tract tumor with a high incidence rate worldwide. Currently, the clinical treatment of CRC predominantly include surgical resection, postoperative chemotherapy, and radiotherapy. However, these treatments contain severe limitations such...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.956793/full |
| _version_ | 1828178660390076416 |
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| author | Mingchuan Wang Xianjun Liu Tong Chen Xianbin Cheng Huijie Xiao Xianglong Meng Yang Jiang |
| author_facet | Mingchuan Wang Xianjun Liu Tong Chen Xianbin Cheng Huijie Xiao Xianglong Meng Yang Jiang |
| author_sort | Mingchuan Wang |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is a common type of malignant digestive tract tumor with a high incidence rate worldwide. Currently, the clinical treatment of CRC predominantly include surgical resection, postoperative chemotherapy, and radiotherapy. However, these treatments contain severe limitations such as drug side effects, the risk of recurrence and drug resistance. Some natural compounds found in plants, fungi, marine animals, and bacteria have been shown to inhibit the occurrence and development of CRC. Although the explicit molecular mechanisms underlying the therapeutic effects of these compounds on CRC are not clear, classical signaling transduction pathways such as NF-kB and Wnt/β-catenin are extensively regulated. In this review, we have summarized the specific mechanisms regulating the inhibition and development of CRC by various types of natural compounds through nine signaling pathways, and explored the potential therapeutic values of these natural compounds in the clinical treatment of CRC. |
| first_indexed | 2024-04-12T05:19:40Z |
| format | Article |
| id | doaj.art-d5713f6e792b4a47abe4394a889eeee4 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T05:19:40Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-d5713f6e792b4a47abe4394a889eeee42022-12-22T03:46:33ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-09-011210.3389/fonc.2022.956793956793Inhibition and potential treatment of colorectal cancer by natural compounds via various signaling pathwaysMingchuan Wang0Xianjun Liu1Tong Chen2Xianbin Cheng3Huijie Xiao4Xianglong Meng5Yang Jiang6Department of Gastrointestinal Colorectal and Anal Surgery, The China-Japan Union Hospital of Jilin University, Changchun, ChinaCollege of Food Engineering, Jilin Engineering Normal University, Changchun, ChinaDepartment of Gastrointestinal Colorectal and Anal Surgery, The China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Thyroid Surgery, The Second Hospital of Jilin University, Changchun, ChinaDepartment of Gastrointestinal Colorectal and Anal Surgery, The China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Burns Surgery, The First Hospital of Jilin University, Changchun, ChinaDepartment of Gastrointestinal Colorectal and Anal Surgery, The China-Japan Union Hospital of Jilin University, Changchun, ChinaColorectal cancer (CRC) is a common type of malignant digestive tract tumor with a high incidence rate worldwide. Currently, the clinical treatment of CRC predominantly include surgical resection, postoperative chemotherapy, and radiotherapy. However, these treatments contain severe limitations such as drug side effects, the risk of recurrence and drug resistance. Some natural compounds found in plants, fungi, marine animals, and bacteria have been shown to inhibit the occurrence and development of CRC. Although the explicit molecular mechanisms underlying the therapeutic effects of these compounds on CRC are not clear, classical signaling transduction pathways such as NF-kB and Wnt/β-catenin are extensively regulated. In this review, we have summarized the specific mechanisms regulating the inhibition and development of CRC by various types of natural compounds through nine signaling pathways, and explored the potential therapeutic values of these natural compounds in the clinical treatment of CRC.https://www.frontiersin.org/articles/10.3389/fonc.2022.956793/fullcolorectal cancernatural compoundssignaling pathwayflavonoidspolyphenol |
| spellingShingle | Mingchuan Wang Xianjun Liu Tong Chen Xianbin Cheng Huijie Xiao Xianglong Meng Yang Jiang Inhibition and potential treatment of colorectal cancer by natural compounds via various signaling pathways Frontiers in Oncology colorectal cancer natural compounds signaling pathway flavonoids polyphenol |
| title | Inhibition and potential treatment of colorectal cancer by natural compounds via various signaling pathways |
| title_full | Inhibition and potential treatment of colorectal cancer by natural compounds via various signaling pathways |
| title_fullStr | Inhibition and potential treatment of colorectal cancer by natural compounds via various signaling pathways |
| title_full_unstemmed | Inhibition and potential treatment of colorectal cancer by natural compounds via various signaling pathways |
| title_short | Inhibition and potential treatment of colorectal cancer by natural compounds via various signaling pathways |
| title_sort | inhibition and potential treatment of colorectal cancer by natural compounds via various signaling pathways |
| topic | colorectal cancer natural compounds signaling pathway flavonoids polyphenol |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.956793/full |
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