Diindolylmethane Derivatives: New Selective Blockers for T-Type Calcium Channels

Diindolylmethane Derivatives: New Selective Blockers for T-Type Calcium Channels

The natural product indole-3-carbinol (I3C) and its major digestive product 3,3′-diindolylmethane (DIM) have shown clinical promise in multiple forms of cancer including breast cancer. In this study, we explored the calcium channel activity of DIM, its synthetic derivative 3,3′-Diindolylmethanone (D...

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Bibliographic Details
Main Authors: Dan Wang, Pratik Neupane, Lotten Ragnarsson, Robert J. Capon, Richard J. Lewis
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Membranes
Subjects:
3,3′-diindolylmethane
natural anticancer agent
T-type calcium channels
selective blockers
Online Access:https://www.mdpi.com/2077-0375/12/8/749

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