11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial
Glucocorticoids prescribed to limit inflammation, have significant adverse effects. Here the authors show that co-administration of AZD4017 with prednisolone in men is a potential strategy to limit adverse glucocorticoid effects.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36541-w |
| _version_ | 1797864313394823168 |
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| author | Nantia Othonos Riccardo Pofi Anastasia Arvaniti Sarah White Ilaria Bonaventura Nikolaos Nikolaou Ahmad Moolla Thomas Marjot Roland H. Stimson André P. van Beek Martijn van Faassen Andrea M. Isidori Elizabeth Bateman Ross Sadler Fredrik Karpe Paul M. Stewart Craig Webster Joanne Duffy Richard Eastell Fatma Gossiel Thomas Cornfield Leanne Hodson K. Jane Escott Andrew Whittaker Ufuk Kirik Ruth L. Coleman Charles A. B. Scott Joanne E. Milton Olorunsola Agbaje Rury R. Holman Jeremy W. Tomlinson |
| author_facet | Nantia Othonos Riccardo Pofi Anastasia Arvaniti Sarah White Ilaria Bonaventura Nikolaos Nikolaou Ahmad Moolla Thomas Marjot Roland H. Stimson André P. van Beek Martijn van Faassen Andrea M. Isidori Elizabeth Bateman Ross Sadler Fredrik Karpe Paul M. Stewart Craig Webster Joanne Duffy Richard Eastell Fatma Gossiel Thomas Cornfield Leanne Hodson K. Jane Escott Andrew Whittaker Ufuk Kirik Ruth L. Coleman Charles A. B. Scott Joanne E. Milton Olorunsola Agbaje Rury R. Holman Jeremy W. Tomlinson |
| author_sort | Nantia Othonos |
| collection | DOAJ |
| description | Glucocorticoids prescribed to limit inflammation, have significant adverse effects. Here the authors show that co-administration of AZD4017 with prednisolone in men is a potential strategy to limit adverse glucocorticoid effects. |
| first_indexed | 2024-04-09T22:50:53Z |
| format | Article |
| id | doaj.art-d5729cc721e9453cb5043aab11c131a3 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:50:53Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d5729cc721e9453cb5043aab11c131a32023-03-22T11:40:42ZengNature PortfolioNature Communications2041-17232023-02-0114111210.1038/s41467-023-36541-w11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trialNantia Othonos0Riccardo Pofi1Anastasia Arvaniti2Sarah White3Ilaria Bonaventura4Nikolaos Nikolaou5Ahmad Moolla6Thomas Marjot7Roland H. Stimson8André P. van Beek9Martijn van Faassen10Andrea M. Isidori11Elizabeth Bateman12Ross Sadler13Fredrik Karpe14Paul M. Stewart15Craig Webster16Joanne Duffy17Richard Eastell18Fatma Gossiel19Thomas Cornfield20Leanne Hodson21K. Jane Escott22Andrew Whittaker23Ufuk Kirik24Ruth L. Coleman25Charles A. B. Scott26Joanne E. Milton27Olorunsola Agbaje28Rury R. Holman29Jeremy W. Tomlinson30Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill HospitalOxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill HospitalOxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill HospitalOxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill HospitalOxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill HospitalOxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill HospitalOxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill HospitalOxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill HospitalUniversity/BHF Centre for Cardiovascular Science, University of EdinburghDepartment of Endocrinology, University of Groningen, University Medical Center GroningenDepartment of Laboratory Medicine, University of Groningen, University Medical Center GroningenDepartment of Experimental Medicine, Sapienza University of RomeDepartment of Immunology, Churchill HospitalDepartment of Immunology, Churchill HospitalOxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill HospitalFaculty of Medicine & Health, University of LeedsDepartment of Pathology, University Hospitals Birmingham, NHS Foundation TrustDepartment of Pathology, University Hospitals Birmingham, NHS Foundation TrustMellanby Centre for Musculoskeletal Research, Department of Oncology & Metabolism, Faculty of Medicine, Dentistry & Health, University of SheffieldMellanby Centre for Musculoskeletal Research, Department of Oncology & Metabolism, Faculty of Medicine, Dentistry & Health, University of SheffieldOxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill HospitalOxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill HospitalBusiness Development & Licensing, BioPharmaceuticals R&D, AstraZenecaEmerging Innovations Unit, Discovery Sciences, BioPharmaceuticals R&D, AstraZenecaQuantitative Biology, Discovery Sciences, BioPharmaceuticals R&D AstraZenecaOxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill HospitalOxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill HospitalOxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill HospitalOxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill HospitalOxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill HospitalOxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill HospitalGlucocorticoids prescribed to limit inflammation, have significant adverse effects. Here the authors show that co-administration of AZD4017 with prednisolone in men is a potential strategy to limit adverse glucocorticoid effects.https://doi.org/10.1038/s41467-023-36541-w |
| spellingShingle | Nantia Othonos Riccardo Pofi Anastasia Arvaniti Sarah White Ilaria Bonaventura Nikolaos Nikolaou Ahmad Moolla Thomas Marjot Roland H. Stimson André P. van Beek Martijn van Faassen Andrea M. Isidori Elizabeth Bateman Ross Sadler Fredrik Karpe Paul M. Stewart Craig Webster Joanne Duffy Richard Eastell Fatma Gossiel Thomas Cornfield Leanne Hodson K. Jane Escott Andrew Whittaker Ufuk Kirik Ruth L. Coleman Charles A. B. Scott Joanne E. Milton Olorunsola Agbaje Rury R. Holman Jeremy W. Tomlinson 11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial Nature Communications |
| title | 11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial |
| title_full | 11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial |
| title_fullStr | 11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial |
| title_full_unstemmed | 11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial |
| title_short | 11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial |
| title_sort | 11β hsd1 inhibition in men mitigates prednisolone induced adverse effects in a proof of concept randomised double blind placebo controlled trial |
| url | https://doi.org/10.1038/s41467-023-36541-w |
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