IMMUNOMODULATORY EFFECTS OF BESTIM IN PATIENTS WITH PEPTIC ULCER
<strong>Abstract. </strong>Ulcer disease is accompanied by all immune responses with the development of secondary immune deficiency. We studied 92 males with peptic ulcer having positive tests for Helicobacter pylori (24 gastric ulcer, mean age 44,7±1,97 and 68 duodenal ulcer, mean age 3...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | http://mimmun.ru/index.php/mimmun/article/view/653 |
| _version_ | 1797724806722879488 |
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| author | A. G. Tkacheva A. I. Dolgushina K. V. Nikushina A. S. Simbirtsev |
| author_facet | A. G. Tkacheva A. I. Dolgushina K. V. Nikushina A. S. Simbirtsev |
| author_sort | A. G. Tkacheva |
| collection | DOAJ |
| description | <strong>Abstract. </strong>Ulcer disease is accompanied by all immune responses with the development of secondary immune deficiency. We studied 92 males with peptic ulcer having positive tests for Helicobacter pylori (24 gastric ulcer, mean age 44,7±1,97 and 68 duodenal ulcer, mean age 31,5±1,71). A half of the patients used only basis antiulcer treatment. 46 patients used bestim in the dose100 mcg per day intramusculare for a 5 days with antisecretory and antihelicobacter drugs. The addition of bestim normalized cellular immunity: count of T-lymphocytes rose from 20,52±0,89% to 31,4±1,16% (p<0,05; confidence interval [CI]: 2,67-11,63). A positive trend in the number of T-lymphocytes was accompanied with increasing of T-helpers from 17,33±0,89% to 24,82±1,11% (p<0,05; 95%CI: 1,72-8,47). In the course of the treatment we observed normalization of monocytes number, an increase of neutrophils activity in blood (p<0,05; 95%CI: 2,35-15,64). We demonstrated decrease in IL-8 production and increase in IFN gamma production. Thus, the application of a new drug Bestim in the combined antiulcer treatment affects the immune state of the patients favourably. It decreases the inflammatory effect in the stomach and duodenal mucosa, it precipitate regress of clinical symptoms and healing of the ulcer. |
| first_indexed | 2024-03-12T10:22:07Z |
| format | Article |
| id | doaj.art-d573419000114b45bf6a45334ccfce5a |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-03-12T10:22:07Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-d573419000114b45bf6a45334ccfce5a2023-09-02T10:02:39ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0175–661161610.15789/1563-0625-2005-5–6-611-616650IMMUNOMODULATORY EFFECTS OF BESTIM IN PATIENTS WITH PEPTIC ULCERA. G. Tkacheva0A. I. Dolgushina1K. V. Nikushina2A. S. Simbirtsev3Челябинская государственная медицинская академияЧелябинская государственная медицинская академияЧелябинская государственная медицинская академияГНЦ НИИ особо чистых биопрепаратов, Санкт–Петербург<strong>Abstract. </strong>Ulcer disease is accompanied by all immune responses with the development of secondary immune deficiency. We studied 92 males with peptic ulcer having positive tests for Helicobacter pylori (24 gastric ulcer, mean age 44,7±1,97 and 68 duodenal ulcer, mean age 31,5±1,71). A half of the patients used only basis antiulcer treatment. 46 patients used bestim in the dose100 mcg per day intramusculare for a 5 days with antisecretory and antihelicobacter drugs. The addition of bestim normalized cellular immunity: count of T-lymphocytes rose from 20,52±0,89% to 31,4±1,16% (p<0,05; confidence interval [CI]: 2,67-11,63). A positive trend in the number of T-lymphocytes was accompanied with increasing of T-helpers from 17,33±0,89% to 24,82±1,11% (p<0,05; 95%CI: 1,72-8,47). In the course of the treatment we observed normalization of monocytes number, an increase of neutrophils activity in blood (p<0,05; 95%CI: 2,35-15,64). We demonstrated decrease in IL-8 production and increase in IFN gamma production. Thus, the application of a new drug Bestim in the combined antiulcer treatment affects the immune state of the patients favourably. It decreases the inflammatory effect in the stomach and duodenal mucosa, it precipitate regress of clinical symptoms and healing of the ulcer.http://mimmun.ru/index.php/mimmun/article/view/653BestimimmunityТ–helpersHelicobacter pylorigastric ulcer disease |
| spellingShingle | A. G. Tkacheva A. I. Dolgushina K. V. Nikushina A. S. Simbirtsev IMMUNOMODULATORY EFFECTS OF BESTIM IN PATIENTS WITH PEPTIC ULCER Медицинская иммунология Bestim immunity Т–helpers Helicobacter pylori gastric ulcer disease |
| title | IMMUNOMODULATORY EFFECTS OF BESTIM IN PATIENTS WITH PEPTIC ULCER |
| title_full | IMMUNOMODULATORY EFFECTS OF BESTIM IN PATIENTS WITH PEPTIC ULCER |
| title_fullStr | IMMUNOMODULATORY EFFECTS OF BESTIM IN PATIENTS WITH PEPTIC ULCER |
| title_full_unstemmed | IMMUNOMODULATORY EFFECTS OF BESTIM IN PATIENTS WITH PEPTIC ULCER |
| title_short | IMMUNOMODULATORY EFFECTS OF BESTIM IN PATIENTS WITH PEPTIC ULCER |
| title_sort | immunomodulatory effects of bestim in patients with peptic ulcer |
| topic | Bestim immunity Т–helpers Helicobacter pylori gastric ulcer disease |
| url | http://mimmun.ru/index.php/mimmun/article/view/653 |
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