Diagnostic value of “hyperdense consolidation sign” as a characteristic new computed tomography sign of diffuse alveolar hemorrhage

Abstract Diffuse alveolar hemorrhage (DAH) is an uncommon but life-threatening condition. Although DAH must be distinguished from other lung diseases, no specific computed tomography (CT) signs of DAH have been reported. This study aimed to evaluate the diagnostic value of “hyperdense consolidation”...

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Main Authors: Soma Kumasaka, Yuka Kumasaka, Akiko Jingu, Yoshito Tsushima
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-25740-y
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author Soma Kumasaka
Yuka Kumasaka
Akiko Jingu
Yoshito Tsushima
author_facet Soma Kumasaka
Yuka Kumasaka
Akiko Jingu
Yoshito Tsushima
author_sort Soma Kumasaka
collection DOAJ
description Abstract Diffuse alveolar hemorrhage (DAH) is an uncommon but life-threatening condition. Although DAH must be distinguished from other lung diseases, no specific computed tomography (CT) signs of DAH have been reported. This study aimed to evaluate the diagnostic value of “hyperdense consolidation” CT sign. We retrospectively evaluated non-contrast CT findings of 25 DAH patients and age- (≤ 2 years) and sex-matched controls with symptoms of dyspnea and hypoxemia. Two radiologists compared the two groups for the presence of hyperdense consolidation signs in lung parenchyma, defined as consolidation that visually contains areas with higher density than the aorta in the specific narrow window setting (window level = 35 Hounsfield units [HU], width = 80 HU) with a mediastinal filter. The sensitivity, specificity, positive- and negative-predictive values of the hyperdense consolidation sign for detection of DAH were 32.0%, 100%, 100%, and 59.5% with perfect interobserver agreement (к = 1.00). The hyperdense consolidation sign was found to be a highly specific sign for DAH.
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spelling doaj.art-d573c07c0e644b23836fa153583dbb952022-12-22T02:56:44ZengNature PortfolioScientific Reports2045-23222022-12-011211710.1038/s41598-022-25740-yDiagnostic value of “hyperdense consolidation sign” as a characteristic new computed tomography sign of diffuse alveolar hemorrhageSoma Kumasaka0Yuka Kumasaka1Akiko Jingu2Yoshito Tsushima3Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of MedicineDepartment of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of MedicineDepartment of Diagnostic Radiology, Fujioka General HospitalDepartment of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of MedicineAbstract Diffuse alveolar hemorrhage (DAH) is an uncommon but life-threatening condition. Although DAH must be distinguished from other lung diseases, no specific computed tomography (CT) signs of DAH have been reported. This study aimed to evaluate the diagnostic value of “hyperdense consolidation” CT sign. We retrospectively evaluated non-contrast CT findings of 25 DAH patients and age- (≤ 2 years) and sex-matched controls with symptoms of dyspnea and hypoxemia. Two radiologists compared the two groups for the presence of hyperdense consolidation signs in lung parenchyma, defined as consolidation that visually contains areas with higher density than the aorta in the specific narrow window setting (window level = 35 Hounsfield units [HU], width = 80 HU) with a mediastinal filter. The sensitivity, specificity, positive- and negative-predictive values of the hyperdense consolidation sign for detection of DAH were 32.0%, 100%, 100%, and 59.5% with perfect interobserver agreement (к = 1.00). The hyperdense consolidation sign was found to be a highly specific sign for DAH.https://doi.org/10.1038/s41598-022-25740-y
spellingShingle Soma Kumasaka
Yuka Kumasaka
Akiko Jingu
Yoshito Tsushima
Diagnostic value of “hyperdense consolidation sign” as a characteristic new computed tomography sign of diffuse alveolar hemorrhage
Scientific Reports
title Diagnostic value of “hyperdense consolidation sign” as a characteristic new computed tomography sign of diffuse alveolar hemorrhage
title_full Diagnostic value of “hyperdense consolidation sign” as a characteristic new computed tomography sign of diffuse alveolar hemorrhage
title_fullStr Diagnostic value of “hyperdense consolidation sign” as a characteristic new computed tomography sign of diffuse alveolar hemorrhage
title_full_unstemmed Diagnostic value of “hyperdense consolidation sign” as a characteristic new computed tomography sign of diffuse alveolar hemorrhage
title_short Diagnostic value of “hyperdense consolidation sign” as a characteristic new computed tomography sign of diffuse alveolar hemorrhage
title_sort diagnostic value of hyperdense consolidation sign as a characteristic new computed tomography sign of diffuse alveolar hemorrhage
url https://doi.org/10.1038/s41598-022-25740-y
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