Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK Biobank participants
Abstract Theory predicts that biological processes of aging may contribute to poor mental health in late life. To test this hypothesis, we evaluated prospective associations between biological age and incident depression and anxiety in 424,299 UK Biobank participants. We measured biological age from...
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| Format: | Article |
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Nature Portfolio
2023-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-38013-7 |
| _version_ | 1827709925191581696 |
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| author | Xu Gao Tong Geng Meijie Jiang Ninghao Huang Yinan Zheng Daniel W. Belsky Tao Huang |
| author_facet | Xu Gao Tong Geng Meijie Jiang Ninghao Huang Yinan Zheng Daniel W. Belsky Tao Huang |
| author_sort | Xu Gao |
| collection | DOAJ |
| description | Abstract Theory predicts that biological processes of aging may contribute to poor mental health in late life. To test this hypothesis, we evaluated prospective associations between biological age and incident depression and anxiety in 424,299 UK Biobank participants. We measured biological age from clinical traits using the KDM-BA and PhenoAge algorithms. At baseline, participants who were biologically older more often experienced depression/anxiety. During a median of 8.7 years of follow-up, participants with older biological age were at increased risk of incident depression/anxiety (5.9% increase per standard deviation [SD] of KDM-BA acceleration, 95% confidence intervals [CI]: 3.3%–8.5%; 11.3% increase per SD of PhenoAge acceleration, 95% CI: 9.%–13.0%). Biological-aging-associated risk of depression/anxiety was independent of and additive to genetic risk measured by genome-wide-association-study-based polygenic scores. Advanced biological aging may represent a potential risk factor for incident depression/anxiety in midlife and older adults and a potential target for risk assessment and intervention. |
| first_indexed | 2024-03-10T17:31:04Z |
| format | Article |
| id | doaj.art-d573d8f9f47f4abcb5cd796ffa1de135 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-10T17:31:04Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d573d8f9f47f4abcb5cd796ffa1de1352023-11-20T10:02:50ZengNature PortfolioNature Communications2041-17232023-04-0114111210.1038/s41467-023-38013-7Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK Biobank participantsXu Gao0Tong Geng1Meijie Jiang2Ninghao Huang3Yinan Zheng4Daniel W. Belsky5Tao Huang6Department of Occupational and Environmental Health Sciences, School of Public Health, Peking UniversityPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital)Department of Occupational and Environmental Health Sciences, School of Public Health, Peking UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Peking UniversityDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern UniversityDepartment of Epidemiology & Butler Columbia Aging Center, Columbia UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Peking UniversityAbstract Theory predicts that biological processes of aging may contribute to poor mental health in late life. To test this hypothesis, we evaluated prospective associations between biological age and incident depression and anxiety in 424,299 UK Biobank participants. We measured biological age from clinical traits using the KDM-BA and PhenoAge algorithms. At baseline, participants who were biologically older more often experienced depression/anxiety. During a median of 8.7 years of follow-up, participants with older biological age were at increased risk of incident depression/anxiety (5.9% increase per standard deviation [SD] of KDM-BA acceleration, 95% confidence intervals [CI]: 3.3%–8.5%; 11.3% increase per SD of PhenoAge acceleration, 95% CI: 9.%–13.0%). Biological-aging-associated risk of depression/anxiety was independent of and additive to genetic risk measured by genome-wide-association-study-based polygenic scores. Advanced biological aging may represent a potential risk factor for incident depression/anxiety in midlife and older adults and a potential target for risk assessment and intervention.https://doi.org/10.1038/s41467-023-38013-7 |
| spellingShingle | Xu Gao Tong Geng Meijie Jiang Ninghao Huang Yinan Zheng Daniel W. Belsky Tao Huang Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK Biobank participants Nature Communications |
| title | Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK Biobank participants |
| title_full | Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK Biobank participants |
| title_fullStr | Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK Biobank participants |
| title_full_unstemmed | Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK Biobank participants |
| title_short | Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK Biobank participants |
| title_sort | accelerated biological aging and risk of depression and anxiety evidence from 424 299 uk biobank participants |
| url | https://doi.org/10.1038/s41467-023-38013-7 |
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