A short review on structure and role of cyclic-3',5'-adenosine monophosphate-specific phosphodiesterase 4 as a treatment tool
Cyclic nucleotide phosphodiesterases (PDEs) are known as a super-family of enzymes which catalyze the metabolism of the intracellular cyclic nucleotides, cyclic-3',5'-adenosine monophosphate (cAMP), and cyclic-3',5'-guanosine monophosphate that are expressed in a variety of cell...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Journal of Research in Pharmacy Practice |
| Subjects: | |
| Online Access: | http://www.jrpp.net/article.asp?issn=2319-9644;year=2015;volume=4;issue=4;spage=175;epage=181;aulast=Eskandari |
| _version_ | 1811263465379069952 |
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| author | Nahid Eskandari Omid Mirmosayyeb Gazaleh Bordbari Reza Bastan Zahra Yousefi Alireza Andalib |
| author_facet | Nahid Eskandari Omid Mirmosayyeb Gazaleh Bordbari Reza Bastan Zahra Yousefi Alireza Andalib |
| author_sort | Nahid Eskandari |
| collection | DOAJ |
| description | Cyclic nucleotide phosphodiesterases (PDEs) are known as a super-family of enzymes which catalyze the metabolism of the intracellular cyclic nucleotides, cyclic-3',5'-adenosine monophosphate (cAMP), and cyclic-3',5'-guanosine monophosphate that are expressed in a variety of cell types that can exert various functions based on their cells distribution. The PDE4 family has been the focus of vast research efforts over recent years because this family is considered as a prime target for therapeutic intervention in a number of inflammatory diseases such as asthma, chronic obstructive pulmonary disease, and rheumatoid arthritis, and it should be used and researched by pharmacists. This is because the major isoform of PDE that regulates inflammatory cell activity is the cAMP-specific PDE, PDE4. This review discusses the relationship between PDE4 and its inhibitor drugs based on structures, cells distribution, and pharmacological properties of PDE4 which can be informative for all pharmacy specialists. |
| first_indexed | 2024-04-12T19:44:40Z |
| format | Article |
| id | doaj.art-d574a156b9434374bd49697ef9f77065 |
| institution | Directory Open Access Journal |
| issn | 2319-9644 2279-042X |
| language | English |
| last_indexed | 2024-04-12T19:44:40Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Pharmacy Practice |
| spelling | doaj.art-d574a156b9434374bd49697ef9f770652022-12-22T03:18:59ZengWolters Kluwer Medknow PublicationsJournal of Research in Pharmacy Practice2319-96442279-042X2015-01-014417518110.4103/2279-042X.167043A short review on structure and role of cyclic-3',5'-adenosine monophosphate-specific phosphodiesterase 4 as a treatment toolNahid EskandariOmid MirmosayyebGazaleh BordbariReza BastanZahra YousefiAlireza AndalibCyclic nucleotide phosphodiesterases (PDEs) are known as a super-family of enzymes which catalyze the metabolism of the intracellular cyclic nucleotides, cyclic-3',5'-adenosine monophosphate (cAMP), and cyclic-3',5'-guanosine monophosphate that are expressed in a variety of cell types that can exert various functions based on their cells distribution. The PDE4 family has been the focus of vast research efforts over recent years because this family is considered as a prime target for therapeutic intervention in a number of inflammatory diseases such as asthma, chronic obstructive pulmonary disease, and rheumatoid arthritis, and it should be used and researched by pharmacists. This is because the major isoform of PDE that regulates inflammatory cell activity is the cAMP-specific PDE, PDE4. This review discusses the relationship between PDE4 and its inhibitor drugs based on structures, cells distribution, and pharmacological properties of PDE4 which can be informative for all pharmacy specialists.http://www.jrpp.net/article.asp?issn=2319-9644;year=2015;volume=4;issue=4;spage=175;epage=181;aulast=EskandariCyclic-3'5'-adenosine monophosphate; inhibitors; phosphodiesterase; phosphodiesterase 4 |
| spellingShingle | Nahid Eskandari Omid Mirmosayyeb Gazaleh Bordbari Reza Bastan Zahra Yousefi Alireza Andalib A short review on structure and role of cyclic-3',5'-adenosine monophosphate-specific phosphodiesterase 4 as a treatment tool Journal of Research in Pharmacy Practice Cyclic-3' 5'-adenosine monophosphate; inhibitors; phosphodiesterase; phosphodiesterase 4 |
| title | A short review on structure and role of cyclic-3',5'-adenosine monophosphate-specific phosphodiesterase 4 as a treatment tool |
| title_full | A short review on structure and role of cyclic-3',5'-adenosine monophosphate-specific phosphodiesterase 4 as a treatment tool |
| title_fullStr | A short review on structure and role of cyclic-3',5'-adenosine monophosphate-specific phosphodiesterase 4 as a treatment tool |
| title_full_unstemmed | A short review on structure and role of cyclic-3',5'-adenosine monophosphate-specific phosphodiesterase 4 as a treatment tool |
| title_short | A short review on structure and role of cyclic-3',5'-adenosine monophosphate-specific phosphodiesterase 4 as a treatment tool |
| title_sort | short review on structure and role of cyclic 3 5 adenosine monophosphate specific phosphodiesterase 4 as a treatment tool |
| topic | Cyclic-3' 5'-adenosine monophosphate; inhibitors; phosphodiesterase; phosphodiesterase 4 |
| url | http://www.jrpp.net/article.asp?issn=2319-9644;year=2015;volume=4;issue=4;spage=175;epage=181;aulast=Eskandari |
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