Role of the Autism Risk Gene <i>Shank3</i> in the Development of Atherosclerosis: Insights from Big Data and Mechanistic Analyses

Role of the Autism Risk Gene <i>Shank3</i> in the Development of Atherosclerosis: Insights from Big Data and Mechanistic Analyses

Increased medical attention is needed as the prevalence of autism spectrum disorder (ASD) rises. Both cardiovascular disorder (CVD) and hyperlipidemia are closely associated with adult ASD. <i>Shank3</i> plays a key genetic role in ASD. We hypothesized that Shank3 contributes to CVD deve...

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Bibliographic Details
Main Authors: Hsiu-Wen Chang, Ming-Jen Hsu, Li-Nien Chien, Nai-Fang Chi, Meng-Chieh Yu, Hsiu-Chen Chen, Yuan-Feng Lin, Chaur-Jong Hu
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cells
Subjects:
<i>Shank3</i>
autism spectrum disorder
atherosclerosis
lipid metabolism
inflammation
cardiovascular disorder
Online Access:https://www.mdpi.com/2073-4409/12/21/2546

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