Associations between single nucleotide polymorphisms in iron-related genes and iron status in multiethnic populations.
The existence of multiple inherited disorders of iron metabolism suggests genetic contributions to iron deficiency. We previously performed a genome-wide association study of iron-related single nucleotide polymorphisms (SNPs) using DNA from white men aged ≥ 25 y and women ≥ 50 y in the Hemochromato...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3382217?pdf=render |
| _version_ | 1818544871250591744 |
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| author | Christine E McLaren Stela McLachlan Chad P Garner Chris D Vulpe Victor R Gordeuk John H Eckfeldt Paul C Adams Ronald T Acton Joseph A Murray Catherine Leiendecker-Foster Beverly M Snively Lisa F Barcellos James D Cook Gordon D McLaren |
| author_facet | Christine E McLaren Stela McLachlan Chad P Garner Chris D Vulpe Victor R Gordeuk John H Eckfeldt Paul C Adams Ronald T Acton Joseph A Murray Catherine Leiendecker-Foster Beverly M Snively Lisa F Barcellos James D Cook Gordon D McLaren |
| author_sort | Christine E McLaren |
| collection | DOAJ |
| description | The existence of multiple inherited disorders of iron metabolism suggests genetic contributions to iron deficiency. We previously performed a genome-wide association study of iron-related single nucleotide polymorphisms (SNPs) using DNA from white men aged ≥ 25 y and women ≥ 50 y in the Hemochromatosis and Iron Overload Screening (HEIRS) Study with serum ferritin (SF) ≤ 12 µg/L (cases) and controls (SF >100 µg/L in men, SF >50 µg/L in women). We report a follow-up study of white, African-American, Hispanic, and Asian HEIRS participants, analyzed for association between SNPs and eight iron-related outcomes. Three chromosomal regions showed association across multiple populations, including SNPs in the TF and TMPRSS6 genes, and on chromosome 18q21. A novel SNP rs1421312 in TMPRSS6 was associated with serum iron in whites (p = 3.7 × 10(-6)) and replicated in African Americans (p = 0.0012).Twenty SNPs in the TF gene region were associated with total iron-binding capacity in whites (p<4.4 × 10(-5)); six SNPs replicated in other ethnicities (p<0.01). SNP rs10904850 in the CUBN gene on 10p13 was associated with serum iron in African Americans (P = 1.0 × 10(-5)). These results confirm known associations with iron measures and give unique evidence of their role in different ethnicities, suggesting origins in a common founder. |
| first_indexed | 2024-12-11T22:54:07Z |
| format | Article |
| id | doaj.art-d5755e27d1bf4d418711620200f170ca |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T22:54:07Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d5755e27d1bf4d418711620200f170ca2022-12-22T00:47:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0176e3833910.1371/journal.pone.0038339Associations between single nucleotide polymorphisms in iron-related genes and iron status in multiethnic populations.Christine E McLarenStela McLachlanChad P GarnerChris D VulpeVictor R GordeukJohn H EckfeldtPaul C AdamsRonald T ActonJoseph A MurrayCatherine Leiendecker-FosterBeverly M SnivelyLisa F BarcellosJames D CookGordon D McLarenThe existence of multiple inherited disorders of iron metabolism suggests genetic contributions to iron deficiency. We previously performed a genome-wide association study of iron-related single nucleotide polymorphisms (SNPs) using DNA from white men aged ≥ 25 y and women ≥ 50 y in the Hemochromatosis and Iron Overload Screening (HEIRS) Study with serum ferritin (SF) ≤ 12 µg/L (cases) and controls (SF >100 µg/L in men, SF >50 µg/L in women). We report a follow-up study of white, African-American, Hispanic, and Asian HEIRS participants, analyzed for association between SNPs and eight iron-related outcomes. Three chromosomal regions showed association across multiple populations, including SNPs in the TF and TMPRSS6 genes, and on chromosome 18q21. A novel SNP rs1421312 in TMPRSS6 was associated with serum iron in whites (p = 3.7 × 10(-6)) and replicated in African Americans (p = 0.0012).Twenty SNPs in the TF gene region were associated with total iron-binding capacity in whites (p<4.4 × 10(-5)); six SNPs replicated in other ethnicities (p<0.01). SNP rs10904850 in the CUBN gene on 10p13 was associated with serum iron in African Americans (P = 1.0 × 10(-5)). These results confirm known associations with iron measures and give unique evidence of their role in different ethnicities, suggesting origins in a common founder.http://europepmc.org/articles/PMC3382217?pdf=render |
| spellingShingle | Christine E McLaren Stela McLachlan Chad P Garner Chris D Vulpe Victor R Gordeuk John H Eckfeldt Paul C Adams Ronald T Acton Joseph A Murray Catherine Leiendecker-Foster Beverly M Snively Lisa F Barcellos James D Cook Gordon D McLaren Associations between single nucleotide polymorphisms in iron-related genes and iron status in multiethnic populations. PLoS ONE |
| title | Associations between single nucleotide polymorphisms in iron-related genes and iron status in multiethnic populations. |
| title_full | Associations between single nucleotide polymorphisms in iron-related genes and iron status in multiethnic populations. |
| title_fullStr | Associations between single nucleotide polymorphisms in iron-related genes and iron status in multiethnic populations. |
| title_full_unstemmed | Associations between single nucleotide polymorphisms in iron-related genes and iron status in multiethnic populations. |
| title_short | Associations between single nucleotide polymorphisms in iron-related genes and iron status in multiethnic populations. |
| title_sort | associations between single nucleotide polymorphisms in iron related genes and iron status in multiethnic populations |
| url | http://europepmc.org/articles/PMC3382217?pdf=render |
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