Clinical characteristics and prognosis in patients with chronic thromboembolic pulmonary hypertension and a concomitant psychiatric disorder
Chronic thromboembolic pulmonary hypertension (CTEPH) can cause right heart failure. A concomitant psychiatric disorder (PD) is thought to increase the risk of acute pulmonary thromboembolism; however, whether PDs are associated with deterioration in CTEPH pathophysiology is unclear. In this study,...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-03-01
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| Series: | Pulmonary Circulation |
| Online Access: | https://doi.org/10.1177/2045894019836420 |
| _version_ | 1818247812659281920 |
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| author | Hiroshi Tajima Hajime Kasai Nobuhiro Tanabe Toshihiko Sugiura Hideki Miwa Akira Naito Rika Suda Rintaro Nishimura Takayuki Jujo Sanada Seiichiro Sakao Koichiro Tatsumi |
| author_facet | Hiroshi Tajima Hajime Kasai Nobuhiro Tanabe Toshihiko Sugiura Hideki Miwa Akira Naito Rika Suda Rintaro Nishimura Takayuki Jujo Sanada Seiichiro Sakao Koichiro Tatsumi |
| author_sort | Hiroshi Tajima |
| collection | DOAJ |
| description | Chronic thromboembolic pulmonary hypertension (CTEPH) can cause right heart failure. A concomitant psychiatric disorder (PD) is thought to increase the risk of acute pulmonary thromboembolism; however, whether PDs are associated with deterioration in CTEPH pathophysiology is unclear. In this study, we evaluated the clinical characteristics and prognoses in patients with CTEPH and a co-existing PD. We retrospectively identified 229 consecutive patients (mean age = 58.7 ± 12.5 years; 160 women) with CTEPH and categorized them according to whether they had a PD (PD group; n = 22, 9.7%) or not (non-PD group; n = 207, 90.3%). We compared the clinical characteristics, respiratory function, hemodynamics, and clinical courses in the two groups. Those in the PD group had significantly lower exercise tolerance compared to the non-PD group (6-min walk test, 309.5 ± 89.5 m vs. 369.4 ± 97.9 m, P = 0.008, percent vital capacity 85.5% ± 17.3% vs. 96.0% ± 15.5%, P = 0.003) and partial pressure of oxygen (PaO 2 ) (54.4 ± 8.6 mmHg vs. 59.3 ± 10.7 mmHg, P = 0.039). Three-year survival was significantly poorer in the PD group compared to the non-PD group (66.1% vs 89.7%, P = 0.0026, log-rank test), particularly in patients who underwent surgery (62.2% vs 89.5%, P < 0.001, log-rank test). A concomitant PD was associated with low exercise tolerance and impaired respiratory function in patients with CTEPH and predicted poor survival, especially in those who underwent a pulmonary endarterectomy. |
| first_indexed | 2024-12-12T15:10:39Z |
| format | Article |
| id | doaj.art-d577c7962d63461383054204cafc0dcc |
| institution | Directory Open Access Journal |
| issn | 2045-8940 |
| language | English |
| last_indexed | 2024-12-12T15:10:39Z |
| publishDate | 2019-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Circulation |
| spelling | doaj.art-d577c7962d63461383054204cafc0dcc2022-12-22T00:20:37ZengWileyPulmonary Circulation2045-89402019-03-01910.1177/2045894019836420Clinical characteristics and prognosis in patients with chronic thromboembolic pulmonary hypertension and a concomitant psychiatric disorderHiroshi Tajima0Hajime Kasai1Nobuhiro Tanabe2Toshihiko Sugiura3Hideki Miwa4Akira Naito5Rika Suda6Rintaro Nishimura7Takayuki Jujo Sanada8Seiichiro Sakao9Koichiro Tatsumi10Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, JapanDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba, JapanDepartment of Advanced Medicine in Pulmonary Hypertension, Graduate School of Medicine, Chiba University, Chiba, JapanDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba, JapanDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba, JapanDepartment of Advancing Research on Treatment Strategies for Respiratory Disease, Graduate School of Medicine, Chiba University, Chiba, JapanDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba, JapanDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba, JapanDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba, JapanDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba, JapanDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba, JapanChronic thromboembolic pulmonary hypertension (CTEPH) can cause right heart failure. A concomitant psychiatric disorder (PD) is thought to increase the risk of acute pulmonary thromboembolism; however, whether PDs are associated with deterioration in CTEPH pathophysiology is unclear. In this study, we evaluated the clinical characteristics and prognoses in patients with CTEPH and a co-existing PD. We retrospectively identified 229 consecutive patients (mean age = 58.7 ± 12.5 years; 160 women) with CTEPH and categorized them according to whether they had a PD (PD group; n = 22, 9.7%) or not (non-PD group; n = 207, 90.3%). We compared the clinical characteristics, respiratory function, hemodynamics, and clinical courses in the two groups. Those in the PD group had significantly lower exercise tolerance compared to the non-PD group (6-min walk test, 309.5 ± 89.5 m vs. 369.4 ± 97.9 m, P = 0.008, percent vital capacity 85.5% ± 17.3% vs. 96.0% ± 15.5%, P = 0.003) and partial pressure of oxygen (PaO 2 ) (54.4 ± 8.6 mmHg vs. 59.3 ± 10.7 mmHg, P = 0.039). Three-year survival was significantly poorer in the PD group compared to the non-PD group (66.1% vs 89.7%, P = 0.0026, log-rank test), particularly in patients who underwent surgery (62.2% vs 89.5%, P < 0.001, log-rank test). A concomitant PD was associated with low exercise tolerance and impaired respiratory function in patients with CTEPH and predicted poor survival, especially in those who underwent a pulmonary endarterectomy.https://doi.org/10.1177/2045894019836420 |
| spellingShingle | Hiroshi Tajima Hajime Kasai Nobuhiro Tanabe Toshihiko Sugiura Hideki Miwa Akira Naito Rika Suda Rintaro Nishimura Takayuki Jujo Sanada Seiichiro Sakao Koichiro Tatsumi Clinical characteristics and prognosis in patients with chronic thromboembolic pulmonary hypertension and a concomitant psychiatric disorder Pulmonary Circulation |
| title | Clinical characteristics and prognosis in patients with chronic thromboembolic pulmonary hypertension and a concomitant psychiatric disorder |
| title_full | Clinical characteristics and prognosis in patients with chronic thromboembolic pulmonary hypertension and a concomitant psychiatric disorder |
| title_fullStr | Clinical characteristics and prognosis in patients with chronic thromboembolic pulmonary hypertension and a concomitant psychiatric disorder |
| title_full_unstemmed | Clinical characteristics and prognosis in patients with chronic thromboembolic pulmonary hypertension and a concomitant psychiatric disorder |
| title_short | Clinical characteristics and prognosis in patients with chronic thromboembolic pulmonary hypertension and a concomitant psychiatric disorder |
| title_sort | clinical characteristics and prognosis in patients with chronic thromboembolic pulmonary hypertension and a concomitant psychiatric disorder |
| url | https://doi.org/10.1177/2045894019836420 |
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