Inflammasome Activation in Pulmonary Arterial Hypertension
Inflammasomes are multi-protein complexes that sense both infectious and sterile inflammatory stimuli, launching a cascade of responses to propagate danger signaling throughout an affected tissue. Recent studies have implicated inflammasome activation in a variety of pulmonary diseases, including pu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.826557/full |
| _version_ | 1818941145535741952 |
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| author | Anna Foley Benjamin E. Steinberg Benjamin E. Steinberg Neil M. Goldenberg Neil M. Goldenberg |
| author_facet | Anna Foley Benjamin E. Steinberg Benjamin E. Steinberg Neil M. Goldenberg Neil M. Goldenberg |
| author_sort | Anna Foley |
| collection | DOAJ |
| description | Inflammasomes are multi-protein complexes that sense both infectious and sterile inflammatory stimuli, launching a cascade of responses to propagate danger signaling throughout an affected tissue. Recent studies have implicated inflammasome activation in a variety of pulmonary diseases, including pulmonary arterial hypertension (PAH). Indeed, the end-products of inflammasome activation, including interleukin (IL)-1β, IL-18, and lytic cell death (“pyroptosis”) are all key biomarkers of PAH, and are potentially therapeutic targets for human disease. This review summarizes current knowledge of inflammasome activation in immune and vascular cells of the lung, with a focus on the role of these pathways in the pathogenesis of PAH. Special emphasis is placed on areas of potential drug development focused on inhibition of inflammasomes and their downstream effectors. |
| first_indexed | 2024-12-20T06:50:53Z |
| format | Article |
| id | doaj.art-d5803c0635b54f71a2481960516c7a65 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-20T06:50:53Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-d5803c0635b54f71a2481960516c7a652022-12-21T19:49:32ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-01-01810.3389/fmed.2021.826557826557Inflammasome Activation in Pulmonary Arterial HypertensionAnna Foley0Benjamin E. Steinberg1Benjamin E. Steinberg2Neil M. Goldenberg3Neil M. Goldenberg4Department of Physiology, University of Toronto, Toronto, ON, CanadaDepartment of Physiology, University of Toronto, Toronto, ON, CanadaDepartment of Anesthesia and Pain Medicine, The Hospital for Sick Children, The University of Toronto, Toronto, ON, CanadaDepartment of Physiology, University of Toronto, Toronto, ON, CanadaDepartment of Anesthesia and Pain Medicine, The Hospital for Sick Children, The University of Toronto, Toronto, ON, CanadaInflammasomes are multi-protein complexes that sense both infectious and sterile inflammatory stimuli, launching a cascade of responses to propagate danger signaling throughout an affected tissue. Recent studies have implicated inflammasome activation in a variety of pulmonary diseases, including pulmonary arterial hypertension (PAH). Indeed, the end-products of inflammasome activation, including interleukin (IL)-1β, IL-18, and lytic cell death (“pyroptosis”) are all key biomarkers of PAH, and are potentially therapeutic targets for human disease. This review summarizes current knowledge of inflammasome activation in immune and vascular cells of the lung, with a focus on the role of these pathways in the pathogenesis of PAH. Special emphasis is placed on areas of potential drug development focused on inhibition of inflammasomes and their downstream effectors.https://www.frontiersin.org/articles/10.3389/fmed.2021.826557/fullpulmonary hypertensioninflammasomemacrophageendothelialvascular remodeling |
| spellingShingle | Anna Foley Benjamin E. Steinberg Benjamin E. Steinberg Neil M. Goldenberg Neil M. Goldenberg Inflammasome Activation in Pulmonary Arterial Hypertension Frontiers in Medicine pulmonary hypertension inflammasome macrophage endothelial vascular remodeling |
| title | Inflammasome Activation in Pulmonary Arterial Hypertension |
| title_full | Inflammasome Activation in Pulmonary Arterial Hypertension |
| title_fullStr | Inflammasome Activation in Pulmonary Arterial Hypertension |
| title_full_unstemmed | Inflammasome Activation in Pulmonary Arterial Hypertension |
| title_short | Inflammasome Activation in Pulmonary Arterial Hypertension |
| title_sort | inflammasome activation in pulmonary arterial hypertension |
| topic | pulmonary hypertension inflammasome macrophage endothelial vascular remodeling |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.826557/full |
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