An Investigation of Salivary Biomarkers in Acute Leukemia Patients
Background: Leukemia is a fatal disease. A proliferation of immature bone marrow-derived cells is called acute leukemia that may also involve solid organs or peripheral blood. A sampling source for clinical diagnosis is saliva which has been used and it is a promising approach as collecting saliva...
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| Format: | Article |
| Language: | English |
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College of medicine/ University of Diyala
2019-05-01
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| Series: | Diyala Journal of Medicine |
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| Online Access: | http://djm.uodiyala.edu.iq/index.php/djm/article/view/225 |
| _version_ | 1797454794873372672 |
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| author | Araz Muhammad Yousif |
| author_facet | Araz Muhammad Yousif |
| author_sort | Araz Muhammad Yousif |
| collection | DOAJ |
| description |
Background: Leukemia is a fatal disease. A proliferation of immature bone marrow-derived cells is called acute leukemia that may also involve solid organs or peripheral blood. A sampling source for clinical diagnosis is saliva which has been used and it is a promising approach as collecting saliva is relatively easy and non-invasive. Over the past two decades, using saliva as biomarker, specifically for early cancer detection has attracted much research interest.
Objective: To estimate the role of some salivary components as biomarkers in patients with acute leukemia.
Patients and Methods: A total of 60 individuals with age range 19-56 years, 30 healthy individuals compared with 30 patients with acute leukemia in order to investigate the following salivary parameters: zinc (Zn), chromium (Cr), copper (Cu), iron (Fe), superoxide dismutase (SOD), and lactate dehydrogenase (LDH) enzymes.
Results: The mean salivary trace elements: Cu, Cr, Fe, and Zn concentrations were significantly raised in patients with acute leukemia when they compared with controls (p<0.005, p<0.05, p< 0.001, and p<0.001 respectively). Also the mean salivary enzymes activities of SOD and LDH were raised significantly in patients with acute leukemia when they compared with healthy subject (p< 0.05 and p<0.001).
Conclusion: altered levels in salivary components in this research may be used as a diagnostic tool, especially when a concurrent analysis for significantly raised markers is carried out. This is because salivary diagnosis involves a non-invasive method, and may thus represent an effective alternative to serum testing.
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| first_indexed | 2024-03-09T15:42:16Z |
| format | Article |
| id | doaj.art-d5836293e055406180382ec7e99fae7c |
| institution | Directory Open Access Journal |
| issn | 2219-9764 2617-8982 |
| language | English |
| last_indexed | 2024-03-09T15:42:16Z |
| publishDate | 2019-05-01 |
| publisher | College of medicine/ University of Diyala |
| record_format | Article |
| series | Diyala Journal of Medicine |
| spelling | doaj.art-d5836293e055406180382ec7e99fae7c2023-11-24T23:24:22ZengCollege of medicine/ University of DiyalaDiyala Journal of Medicine2219-97642617-89822019-05-01111An Investigation of Salivary Biomarkers in Acute Leukemia PatientsAraz Muhammad Yousif Background: Leukemia is a fatal disease. A proliferation of immature bone marrow-derived cells is called acute leukemia that may also involve solid organs or peripheral blood. A sampling source for clinical diagnosis is saliva which has been used and it is a promising approach as collecting saliva is relatively easy and non-invasive. Over the past two decades, using saliva as biomarker, specifically for early cancer detection has attracted much research interest. Objective: To estimate the role of some salivary components as biomarkers in patients with acute leukemia. Patients and Methods: A total of 60 individuals with age range 19-56 years, 30 healthy individuals compared with 30 patients with acute leukemia in order to investigate the following salivary parameters: zinc (Zn), chromium (Cr), copper (Cu), iron (Fe), superoxide dismutase (SOD), and lactate dehydrogenase (LDH) enzymes. Results: The mean salivary trace elements: Cu, Cr, Fe, and Zn concentrations were significantly raised in patients with acute leukemia when they compared with controls (p<0.005, p<0.05, p< 0.001, and p<0.001 respectively). Also the mean salivary enzymes activities of SOD and LDH were raised significantly in patients with acute leukemia when they compared with healthy subject (p< 0.05 and p<0.001). Conclusion: altered levels in salivary components in this research may be used as a diagnostic tool, especially when a concurrent analysis for significantly raised markers is carried out. This is because salivary diagnosis involves a non-invasive method, and may thus represent an effective alternative to serum testing. http://djm.uodiyala.edu.iq/index.php/djm/article/view/225superoxide dismutase (SOD), lactate dehydrogenase (LDH), trace elements, and acute Leukemia |
| spellingShingle | Araz Muhammad Yousif An Investigation of Salivary Biomarkers in Acute Leukemia Patients Diyala Journal of Medicine superoxide dismutase (SOD), lactate dehydrogenase (LDH), trace elements, and acute Leukemia |
| title | An Investigation of Salivary Biomarkers in Acute Leukemia Patients |
| title_full | An Investigation of Salivary Biomarkers in Acute Leukemia Patients |
| title_fullStr | An Investigation of Salivary Biomarkers in Acute Leukemia Patients |
| title_full_unstemmed | An Investigation of Salivary Biomarkers in Acute Leukemia Patients |
| title_short | An Investigation of Salivary Biomarkers in Acute Leukemia Patients |
| title_sort | investigation of salivary biomarkers in acute leukemia patients |
| topic | superoxide dismutase (SOD), lactate dehydrogenase (LDH), trace elements, and acute Leukemia |
| url | http://djm.uodiyala.edu.iq/index.php/djm/article/view/225 |
| work_keys_str_mv | AT arazmuhammadyousif aninvestigationofsalivarybiomarkersinacuteleukemiapatients AT arazmuhammadyousif investigationofsalivarybiomarkersinacuteleukemiapatients |