Comparative study of the inhibitory effects of adrenomedullin on angiotensin II contraction in rat conductance and resistance arteries
Adrenomedullin (ADM), a ubiquitous vasoactive peptide, has been the target of a multitude of studies concerning its effect on the vascular tone. The present work aims at clarifying a series of its interactions with the renin-angiotensin system. The study uses the rat aorta ring as a model of conduct...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publications
2004-06-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.3317/jraas.2004.014 |
| _version_ | 1797285426555256832 |
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| author | Ion Haulica Walther Bild Christian Mihaila Dragomir N Serban Lacramioara Serban Daniela Boisteanu Teodor Ionita Oana Radasanu |
| author_facet | Ion Haulica Walther Bild Christian Mihaila Dragomir N Serban Lacramioara Serban Daniela Boisteanu Teodor Ionita Oana Radasanu |
| author_sort | Ion Haulica |
| collection | DOAJ |
| description | Adrenomedullin (ADM), a ubiquitous vasoactive peptide, has been the target of a multitude of studies concerning its effect on the vascular tone. The present work aims at clarifying a series of its interactions with the renin-angiotensin system. The study uses the rat aorta ring as a model of conductance vessels, with or without vascular endothelium, and the second order branch of rat mesenteric arteries as a model of resistance arteries. Interactions between various concentrations of ADM and angiotensin II (Ang II) were studied, in the presence of L-NAME (a nitric oxide [NO] synthase inhibitor) and methylene blue (MB; a soluble guanylate cyclase inhibitor). Results point out differences in the mechanism of the inhibitory action of ADM upon Ang II effects in the two vessel types studied. Inhibition of Ang II contraction by ADM involves guanylate cyclase in both cases. However, NO is involved in ADM-induced inhibition of angiotensinergic not in the resistance ones. vasoconstriction only in the conductance arteries, not in the resistance ones. |
| first_indexed | 2024-03-07T18:03:00Z |
| format | Article |
| id | doaj.art-d5842c4b41b14ae985737e8f49f3b4c0 |
| institution | Directory Open Access Journal |
| issn | 1470-3203 |
| language | English |
| last_indexed | 2024-03-07T18:03:00Z |
| publishDate | 2004-06-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-d5842c4b41b14ae985737e8f49f3b4c02024-03-02T10:24:02ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32032004-06-01510.3317/jraas.2004.014Comparative study of the inhibitory effects of adrenomedullin on angiotensin II contraction in rat conductance and resistance arteriesIon HaulicaWalther BildChristian MihailaDragomir N SerbanLacramioara SerbanDaniela BoisteanuTeodor IonitaOana RadasanuAdrenomedullin (ADM), a ubiquitous vasoactive peptide, has been the target of a multitude of studies concerning its effect on the vascular tone. The present work aims at clarifying a series of its interactions with the renin-angiotensin system. The study uses the rat aorta ring as a model of conductance vessels, with or without vascular endothelium, and the second order branch of rat mesenteric arteries as a model of resistance arteries. Interactions between various concentrations of ADM and angiotensin II (Ang II) were studied, in the presence of L-NAME (a nitric oxide [NO] synthase inhibitor) and methylene blue (MB; a soluble guanylate cyclase inhibitor). Results point out differences in the mechanism of the inhibitory action of ADM upon Ang II effects in the two vessel types studied. Inhibition of Ang II contraction by ADM involves guanylate cyclase in both cases. However, NO is involved in ADM-induced inhibition of angiotensinergic not in the resistance ones. vasoconstriction only in the conductance arteries, not in the resistance ones.https://doi.org/10.3317/jraas.2004.014 |
| spellingShingle | Ion Haulica Walther Bild Christian Mihaila Dragomir N Serban Lacramioara Serban Daniela Boisteanu Teodor Ionita Oana Radasanu Comparative study of the inhibitory effects of adrenomedullin on angiotensin II contraction in rat conductance and resistance arteries Journal of the Renin-Angiotensin-Aldosterone System |
| title | Comparative study of the inhibitory effects of adrenomedullin on angiotensin II contraction in rat conductance and resistance arteries |
| title_full | Comparative study of the inhibitory effects of adrenomedullin on angiotensin II contraction in rat conductance and resistance arteries |
| title_fullStr | Comparative study of the inhibitory effects of adrenomedullin on angiotensin II contraction in rat conductance and resistance arteries |
| title_full_unstemmed | Comparative study of the inhibitory effects of adrenomedullin on angiotensin II contraction in rat conductance and resistance arteries |
| title_short | Comparative study of the inhibitory effects of adrenomedullin on angiotensin II contraction in rat conductance and resistance arteries |
| title_sort | comparative study of the inhibitory effects of adrenomedullin on angiotensin ii contraction in rat conductance and resistance arteries |
| url | https://doi.org/10.3317/jraas.2004.014 |
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