The Inclusion of Underrepresented Populations in Cardiovascular Genetics and Epidemiology
Novel genetic risk markers have helped us to advance the field of cardiovascular epidemiology and refine our current understanding and risk stratification paradigms. The discovery and analysis of variants can help us to tailor prognostication and management. However, populations underrepresented in...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-02-01
|
| Series: | Journal of Cardiovascular Development and Disease |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2308-3425/11/2/56 |
| _version_ | 1797297900411158528 |
|---|---|
| author | Elias Chappell Laura Arbour Zachary Laksman |
| author_facet | Elias Chappell Laura Arbour Zachary Laksman |
| author_sort | Elias Chappell |
| collection | DOAJ |
| description | Novel genetic risk markers have helped us to advance the field of cardiovascular epidemiology and refine our current understanding and risk stratification paradigms. The discovery and analysis of variants can help us to tailor prognostication and management. However, populations underrepresented in cardiovascular epidemiology and cardiogenetics research may experience inequities in care if prediction tools are not applicable to them clinically. Therefore, the purpose of this article is to outline the barriers that underrepresented populations can face in participating in genetics research, to describe the current efforts to diversify cardiogenetics research, and to outline strategies that researchers in cardiovascular epidemiology can implement to include underrepresented populations. Mistrust, a lack of diverse research teams, the improper use of sensitive biodata, and the constraints of genetic analyses are all barriers for including diverse populations in genetics studies. The current work is beginning to address the paucity of ethnically diverse genetics research and has already begun to shed light on the potential benefits of including underrepresented and diverse populations. Reducing barriers for individuals, utilizing community-driven research processes, adopting novel recruitment strategies, and pushing for organizational support for diverse genetics research are key steps that clinicians and researchers can take to develop equitable risk stratification tools and improve patient care. |
| first_indexed | 2024-03-07T22:28:01Z |
| format | Article |
| id | doaj.art-d584b8bd2f534889a277b95462e8ce7f |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-07T22:28:01Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-d584b8bd2f534889a277b95462e8ce7f2024-02-23T15:21:44ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252024-02-011125610.3390/jcdd11020056The Inclusion of Underrepresented Populations in Cardiovascular Genetics and EpidemiologyElias Chappell0Laura Arbour1Zachary Laksman2Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, CanadaDepartment of Medical Genetics, University of British Columbia, Vancouver, BC V6H 3N1, CanadaDepartment of Medicine and the School of Biomedical Engineering, Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC V6T 1Z4, CanadaNovel genetic risk markers have helped us to advance the field of cardiovascular epidemiology and refine our current understanding and risk stratification paradigms. The discovery and analysis of variants can help us to tailor prognostication and management. However, populations underrepresented in cardiovascular epidemiology and cardiogenetics research may experience inequities in care if prediction tools are not applicable to them clinically. Therefore, the purpose of this article is to outline the barriers that underrepresented populations can face in participating in genetics research, to describe the current efforts to diversify cardiogenetics research, and to outline strategies that researchers in cardiovascular epidemiology can implement to include underrepresented populations. Mistrust, a lack of diverse research teams, the improper use of sensitive biodata, and the constraints of genetic analyses are all barriers for including diverse populations in genetics studies. The current work is beginning to address the paucity of ethnically diverse genetics research and has already begun to shed light on the potential benefits of including underrepresented and diverse populations. Reducing barriers for individuals, utilizing community-driven research processes, adopting novel recruitment strategies, and pushing for organizational support for diverse genetics research are key steps that clinicians and researchers can take to develop equitable risk stratification tools and improve patient care.https://www.mdpi.com/2308-3425/11/2/56cardiovascular epidemiologycardiogeneticsunderrepresented populationsdiversitygeneticsgenomics |
| spellingShingle | Elias Chappell Laura Arbour Zachary Laksman The Inclusion of Underrepresented Populations in Cardiovascular Genetics and Epidemiology Journal of Cardiovascular Development and Disease cardiovascular epidemiology cardiogenetics underrepresented populations diversity genetics genomics |
| title | The Inclusion of Underrepresented Populations in Cardiovascular Genetics and Epidemiology |
| title_full | The Inclusion of Underrepresented Populations in Cardiovascular Genetics and Epidemiology |
| title_fullStr | The Inclusion of Underrepresented Populations in Cardiovascular Genetics and Epidemiology |
| title_full_unstemmed | The Inclusion of Underrepresented Populations in Cardiovascular Genetics and Epidemiology |
| title_short | The Inclusion of Underrepresented Populations in Cardiovascular Genetics and Epidemiology |
| title_sort | inclusion of underrepresented populations in cardiovascular genetics and epidemiology |
| topic | cardiovascular epidemiology cardiogenetics underrepresented populations diversity genetics genomics |
| url | https://www.mdpi.com/2308-3425/11/2/56 |
| work_keys_str_mv | AT eliaschappell theinclusionofunderrepresentedpopulationsincardiovasculargeneticsandepidemiology AT lauraarbour theinclusionofunderrepresentedpopulationsincardiovasculargeneticsandepidemiology AT zacharylaksman theinclusionofunderrepresentedpopulationsincardiovasculargeneticsandepidemiology AT eliaschappell inclusionofunderrepresentedpopulationsincardiovasculargeneticsandepidemiology AT lauraarbour inclusionofunderrepresentedpopulationsincardiovasculargeneticsandepidemiology AT zacharylaksman inclusionofunderrepresentedpopulationsincardiovasculargeneticsandepidemiology |