Boston Type 1 Keratoprosthesis: Updated Perspectives
Manachai Nonpassopon,1,2 Muanploy Niparugs,2,3 Maria Soledad Cortina2 1Department of Ophthalmology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA; 3Department of...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-04-01
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| Series: | Clinical Ophthalmology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/boston-type-1-keratoprosthesis-updated-perspectives-peer-reviewed-article-OPTH |
| _version_ | 1818853629060186112 |
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| author | Nonpassopon M Niparugs M Cortina MS |
| author_facet | Nonpassopon M Niparugs M Cortina MS |
| author_sort | Nonpassopon M |
| collection | DOAJ |
| description | Manachai Nonpassopon,1,2 Muanploy Niparugs,2,3 Maria Soledad Cortina2 1Department of Ophthalmology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA; 3Department of Ophthalmology, Faculty of Medicine, Chaing Mai University, Chaing Mai, ThailandCorrespondence: Maria Soledad CortinaDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1855 W. Taylor Street, M/C 648, Chicago, IL 60612, USATel +1 312 996-6590Email mcortina@uic.eduAbstract: The use of Boston type 1 keratoprosthesis (BKPro) has significantly increased worldwide. It is no longer considered a procedure of last resort but a reasonable option for patients with otherwise poor prognosis for a traditional penetrating keratoplasty. BKPro was approved by the Food and Drug Administration in 1992 for bilateral severe corneal blindness due to multiple corneal transplant failure. Over the years, indications have extended beyond recurrent immunologic rejection to include other conditions such as chemical injury and other causes of bilateral limbal stem cell deficiency, extensive corneal neovascularization, neurotrophic corneas and hypotony, among others. Numerous advances in the design of the BKPro, improvement of preoperative, intraoperative and postoperative management have resulted in favorable outcomes and a reduction in postoperative complications. Accordingly, many studies have shown that implantation of this device is highly effective in restoring vision with very good short-term outcomes. However, due to the lifetime risk of sight-threatening complications after BKPro implantation, a longer follow-up period should provide outcomes that are more realistic. In this review, the authors examined only the results of publications with an average of at least 2 years of follow-up. The overall intermediate to long-term visual outcomes and retention rate in BKPro seem to be favorable. However, autoimmune diseases and cicatrizing conditions continue to show a higher incidence of postoperative complications that require further management.Keywords: Boston keratoprosthesis, corneal transplantation, limbal stem cell deficiency |
| first_indexed | 2024-12-19T07:39:51Z |
| format | Article |
| id | doaj.art-d5857e8813e6450bbcef3a045b39cf13 |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-12-19T07:39:51Z |
| publishDate | 2020-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-d5857e8813e6450bbcef3a045b39cf132022-12-21T20:30:29ZengDove Medical PressClinical Ophthalmology1177-54832020-04-01Volume 141189120053400Boston Type 1 Keratoprosthesis: Updated PerspectivesNonpassopon MNiparugs MCortina MSManachai Nonpassopon,1,2 Muanploy Niparugs,2,3 Maria Soledad Cortina2 1Department of Ophthalmology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA; 3Department of Ophthalmology, Faculty of Medicine, Chaing Mai University, Chaing Mai, ThailandCorrespondence: Maria Soledad CortinaDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1855 W. Taylor Street, M/C 648, Chicago, IL 60612, USATel +1 312 996-6590Email mcortina@uic.eduAbstract: The use of Boston type 1 keratoprosthesis (BKPro) has significantly increased worldwide. It is no longer considered a procedure of last resort but a reasonable option for patients with otherwise poor prognosis for a traditional penetrating keratoplasty. BKPro was approved by the Food and Drug Administration in 1992 for bilateral severe corneal blindness due to multiple corneal transplant failure. Over the years, indications have extended beyond recurrent immunologic rejection to include other conditions such as chemical injury and other causes of bilateral limbal stem cell deficiency, extensive corneal neovascularization, neurotrophic corneas and hypotony, among others. Numerous advances in the design of the BKPro, improvement of preoperative, intraoperative and postoperative management have resulted in favorable outcomes and a reduction in postoperative complications. Accordingly, many studies have shown that implantation of this device is highly effective in restoring vision with very good short-term outcomes. However, due to the lifetime risk of sight-threatening complications after BKPro implantation, a longer follow-up period should provide outcomes that are more realistic. In this review, the authors examined only the results of publications with an average of at least 2 years of follow-up. The overall intermediate to long-term visual outcomes and retention rate in BKPro seem to be favorable. However, autoimmune diseases and cicatrizing conditions continue to show a higher incidence of postoperative complications that require further management.Keywords: Boston keratoprosthesis, corneal transplantation, limbal stem cell deficiencyhttps://www.dovepress.com/boston-type-1-keratoprosthesis-updated-perspectives-peer-reviewed-article-OPTHboston keratoprosthesiscorneal transplantationlimbal stem cell deficiency |
| spellingShingle | Nonpassopon M Niparugs M Cortina MS Boston Type 1 Keratoprosthesis: Updated Perspectives Clinical Ophthalmology boston keratoprosthesis corneal transplantation limbal stem cell deficiency |
| title | Boston Type 1 Keratoprosthesis: Updated Perspectives |
| title_full | Boston Type 1 Keratoprosthesis: Updated Perspectives |
| title_fullStr | Boston Type 1 Keratoprosthesis: Updated Perspectives |
| title_full_unstemmed | Boston Type 1 Keratoprosthesis: Updated Perspectives |
| title_short | Boston Type 1 Keratoprosthesis: Updated Perspectives |
| title_sort | boston type 1 keratoprosthesis updated perspectives |
| topic | boston keratoprosthesis corneal transplantation limbal stem cell deficiency |
| url | https://www.dovepress.com/boston-type-1-keratoprosthesis-updated-perspectives-peer-reviewed-article-OPTH |
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