Consistency of Pituitary Adenoma: Prediction by Pharmacokinetic Dynamic Contrast-Enhanced MRI and Comparison with Histologic Collagen Content
Prediction of tumor consistency is valuable for planning transsphenoidal surgery for pituitary adenoma. A prospective study was conducted involving 49 participants with pituitary adenoma to determine whether quantitative pharmacokinetic analysis of dynamic contrast-enhanced magnetic resonance imagin...
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MDPI AG
2021-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/15/3914 |
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| author | Kiyohisa Kamimura Masanori Nakajo Manisha Bohara Daigo Nagano Yoshihiko Fukukura Shingo Fujio Tomoko Takajo Kazuhiro Tabata Takashi Iwanaga Hiroshi Imai Marcel Dominik Nickel Takashi Yoshiura |
| author_facet | Kiyohisa Kamimura Masanori Nakajo Manisha Bohara Daigo Nagano Yoshihiko Fukukura Shingo Fujio Tomoko Takajo Kazuhiro Tabata Takashi Iwanaga Hiroshi Imai Marcel Dominik Nickel Takashi Yoshiura |
| author_sort | Kiyohisa Kamimura |
| collection | DOAJ |
| description | Prediction of tumor consistency is valuable for planning transsphenoidal surgery for pituitary adenoma. A prospective study was conducted involving 49 participants with pituitary adenoma to determine whether quantitative pharmacokinetic analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is useful for predicting consistency of adenomas. Pharmacokinetic parameters in the adenomas including volume of extravascular extracellular space (EES) per unit volume of tissue (v<sub>e</sub>), blood plasma volume per unit volume of tissue (v<sub>p</sub>), volume transfer constant between blood plasma and EES (K<sup>trans</sup>), and rate constant between EES and blood plasma (k<sub>ep</sub>) were obtained. The pharmacokinetic parameters and the histologic percentage of collagen content (PCC) were compared between soft and hard adenomas using Mann–Whitney <i>U</i> test. Pearson’s correlation coefficient was used to correlate pharmacokinetic parameters with PCC. Hard adenomas showed significantly higher PCC (44.08 ± 15.14% vs. 6.62 ± 3.47%, <i>p</i> < 0.01), v<sub>e</sub> (0.332 ± 0.124% vs. 0.221 ± 0.104%, <i>p</i> < 0.01), and K<sup>trans</sup> (0.775 ± 0.401/min vs. 0.601 ± 0.612/min, <i>p</i> = 0.02) than soft adenomas. Moreover, a significant positive correlation was found between v<sub>e</sub> and PCC (r = 0.601, <i>p</i> < 0.01). The v<sub>e</sub> derived using DCE-MRI may have predictive value for consistency of pituitary adenoma. |
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| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T09:17:20Z |
| publishDate | 2021-08-01 |
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| series | Cancers |
| spelling | doaj.art-d585ff912134416d836ea64ba6b870092023-11-22T05:29:57ZengMDPI AGCancers2072-66942021-08-011315391410.3390/cancers13153914Consistency of Pituitary Adenoma: Prediction by Pharmacokinetic Dynamic Contrast-Enhanced MRI and Comparison with Histologic Collagen ContentKiyohisa Kamimura0Masanori Nakajo1Manisha Bohara2Daigo Nagano3Yoshihiko Fukukura4Shingo Fujio5Tomoko Takajo6Kazuhiro Tabata7Takashi Iwanaga8Hiroshi Imai9Marcel Dominik Nickel10Takashi Yoshiura11Department of Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, JapanDepartment of Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, JapanDepartment of Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, JapanDepartment of Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, JapanDepartment of Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, JapanDepartment of Neurosurgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, JapanDepartment of Neurosurgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, JapanDepartment of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, JapanDepartment of Radiological Technology, Kagoshima University Hospital, 8-35-1 Sakuragaoka, Kagoshima 890-8544, JapanMR Research & Collaboration, Siemens Healthcare K.K., 1-11-1 Osaki, Shinagawa, Tokyo 141-8644, JapanMR Applications Predevelopment, Siemens Healthcare GmbH, 91052 Erlangen, GermanyDepartment of Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, JapanPrediction of tumor consistency is valuable for planning transsphenoidal surgery for pituitary adenoma. A prospective study was conducted involving 49 participants with pituitary adenoma to determine whether quantitative pharmacokinetic analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is useful for predicting consistency of adenomas. Pharmacokinetic parameters in the adenomas including volume of extravascular extracellular space (EES) per unit volume of tissue (v<sub>e</sub>), blood plasma volume per unit volume of tissue (v<sub>p</sub>), volume transfer constant between blood plasma and EES (K<sup>trans</sup>), and rate constant between EES and blood plasma (k<sub>ep</sub>) were obtained. The pharmacokinetic parameters and the histologic percentage of collagen content (PCC) were compared between soft and hard adenomas using Mann–Whitney <i>U</i> test. Pearson’s correlation coefficient was used to correlate pharmacokinetic parameters with PCC. Hard adenomas showed significantly higher PCC (44.08 ± 15.14% vs. 6.62 ± 3.47%, <i>p</i> < 0.01), v<sub>e</sub> (0.332 ± 0.124% vs. 0.221 ± 0.104%, <i>p</i> < 0.01), and K<sup>trans</sup> (0.775 ± 0.401/min vs. 0.601 ± 0.612/min, <i>p</i> = 0.02) than soft adenomas. Moreover, a significant positive correlation was found between v<sub>e</sub> and PCC (r = 0.601, <i>p</i> < 0.01). The v<sub>e</sub> derived using DCE-MRI may have predictive value for consistency of pituitary adenoma.https://www.mdpi.com/2072-6694/13/15/3914pituitary adenomaconsistencymagnetic resonance imagingpharmacokinetic analysiscollagen |
| spellingShingle | Kiyohisa Kamimura Masanori Nakajo Manisha Bohara Daigo Nagano Yoshihiko Fukukura Shingo Fujio Tomoko Takajo Kazuhiro Tabata Takashi Iwanaga Hiroshi Imai Marcel Dominik Nickel Takashi Yoshiura Consistency of Pituitary Adenoma: Prediction by Pharmacokinetic Dynamic Contrast-Enhanced MRI and Comparison with Histologic Collagen Content Cancers pituitary adenoma consistency magnetic resonance imaging pharmacokinetic analysis collagen |
| title | Consistency of Pituitary Adenoma: Prediction by Pharmacokinetic Dynamic Contrast-Enhanced MRI and Comparison with Histologic Collagen Content |
| title_full | Consistency of Pituitary Adenoma: Prediction by Pharmacokinetic Dynamic Contrast-Enhanced MRI and Comparison with Histologic Collagen Content |
| title_fullStr | Consistency of Pituitary Adenoma: Prediction by Pharmacokinetic Dynamic Contrast-Enhanced MRI and Comparison with Histologic Collagen Content |
| title_full_unstemmed | Consistency of Pituitary Adenoma: Prediction by Pharmacokinetic Dynamic Contrast-Enhanced MRI and Comparison with Histologic Collagen Content |
| title_short | Consistency of Pituitary Adenoma: Prediction by Pharmacokinetic Dynamic Contrast-Enhanced MRI and Comparison with Histologic Collagen Content |
| title_sort | consistency of pituitary adenoma prediction by pharmacokinetic dynamic contrast enhanced mri and comparison with histologic collagen content |
| topic | pituitary adenoma consistency magnetic resonance imaging pharmacokinetic analysis collagen |
| url | https://www.mdpi.com/2072-6694/13/15/3914 |
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