Evolutionarily distant I domains can functionally replace the essential ligand-binding domain of Plasmodium TRAP

Evolutionarily distant I domains can functionally replace the essential ligand-binding domain of Plasmodium TRAP

Inserted (I) domains function as ligand-binding domains in adhesins that support cell adhesion and migration in many eukaryotic phyla. These adhesins include integrin αβ heterodimers in metazoans and single subunit transmembrane proteins in apicomplexans such as TRAP in Plasmodium and MIC2 in Toxopl...

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Bibliographic Details
Main Authors: Dennis Klug, Sarah Goellner, Jessica Kehrer, Julia Sattler, Léanne Strauss, Mirko Singer, Chafen Lu, Timothy A Springer, Friedrich Frischknecht
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-07-01
Series:eLife
Subjects:
Plasmodium berghei
malaria
motility
invasion
integrin
adhesion
Online Access:https://elifesciences.org/articles/57572

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