Improving the Oral Bioavailability of an Anti-Glioma Prodrug CAT3 Using Novel Solid Lipid Nanoparticles Containing Oleic Acid-CAT3 Conjugates

Improving the Oral Bioavailability of an Anti-Glioma Prodrug CAT3 Using Novel Solid Lipid Nanoparticles Containing Oleic Acid-CAT3 Conjugates

13a-(S)-3-pivaloyloxyl-6,7-dimethoxyphenanthro(9,10-b)-indolizidine (CAT3) is a novel oral anti-glioma pro-drug with a potent anti-tumor effect against temozolomide-resistant glioma in vivo. However, poor lipid solubility has limited the encapsulation efficacy during formulation development. Moreove...

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Bibliographic Details
Main Authors: Hongliang Wang, Lin Li, Jun Ye, Rubing Wang, Renyun Wang, Jinping Hu, Yanan Wang, Wujun Dong, Xuejun Xia, Yanfang Yang, Yue Gao, Lili Gao, Yuling Liu
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Pharmaceutics
Subjects:
phenanthroindolizidine
prodrug
oleic acid
conjugate
solid lipid nanoparticles
bioavailability
Online Access:https://www.mdpi.com/1999-4923/12/2/126

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