Association of Haptoglobin Phenotypes with Clinical Features of Preterm Labor Disease
Preterm birth means the birth before thirty seven week of pregnancy that causes a lot of complications for the baby. Variety factors are suggested to be involved in disease. In this study, we decided to evaluate haptoglobin (Hp) phenotypes association with clinical features of patients suffered from...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2013-08-01
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| Series: | Acta Medica Iranica |
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| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/4393 |
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| author | Hossein Ali Khazaei Batoul Teymuri Alireza Nakhaei Mehdi Mohammadi Mehrangeez Noura Amin Khazaei Neda Tofiqh Nima Rezaei |
| author_facet | Hossein Ali Khazaei Batoul Teymuri Alireza Nakhaei Mehdi Mohammadi Mehrangeez Noura Amin Khazaei Neda Tofiqh Nima Rezaei |
| author_sort | Hossein Ali Khazaei |
| collection | DOAJ |
| description | Preterm birth means the birth before thirty seven week of pregnancy that causes a lot of complications for the baby. Variety factors are suggested to be involved in disease. In this study, we decided to evaluate haptoglobin (Hp) phenotypes association with clinical features of patients suffered from premature delivery to understand better the possible correlation of genetic and clinical features in this disease. This cross sectional analytic descriptive study has been carried out in two groups of 120 women, 60 with preterm and 60 with term labor. Patients were selected with previously diagnosed by a gynecologist with preterm birth in hospital during the study period. After performing diagnostic tests, the frequency of each haptoglobin phenotype in the two groups was analyzed using the X2 test and SPSS software. The maximum serum haptoglobin phenotype frequency in patients with Hp2-2, was 43 (71.7%) whereas in healthy individuals, 35 (58.3%). No statistically significant differences between the two groups was found (P=0.310). But based on some patients clinical features such as their history of preterm delivery, previous history of recurrent abortions and history of preterm delivery in their family, significant association was found with Hp2-2 compared with healthy control (P<0.003). This study showed that Hp2-2 phenotypes levels in the case group was higher than in control but the factors influencing the presence or absence of preterm labor is clinically various. |
| first_indexed | 2024-12-18T06:06:22Z |
| format | Article |
| id | doaj.art-d58acdaacd4147ad90c272b12d1d7fd0 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-18T06:06:22Z |
| publishDate | 2013-08-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-d58acdaacd4147ad90c272b12d1d7fd02022-12-21T21:18:32ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942013-08-015184346Association of Haptoglobin Phenotypes with Clinical Features of Preterm Labor DiseaseHossein Ali Khazaei0Batoul Teymuri1Alireza Nakhaei2Mehdi Mohammadi3Mehrangeez Noura4Amin Khazaei5Neda Tofiqh6Nima Rezaei7Research Center for Cellular and Molecular; Department of Immunology and Hematology, Zahedan Medical Sciences University, Zahedan, Iran.Department of Biochemistry, Zahedan University of Medical Sciences, Zahedan, Iran.Department of Gynecology, Zahedan University of Medical Sciences, Zahedan, Iran.Department of Biostatistics, Zahedan University of Medical Sciences, Zahedan, Iran.Department of Gynecology, Zahedan University of Medical Sciences, Zahedan, Iran.Research Center for Cellular and Molecular; Department of Immunology and Hematology, Zahedan Medical Sciences University, Zahedan, Iran.Research Center for Cellular and Molecular; Department of Immunology and Hematology, Zahedan Medical Sciences University, Zahedan, Iran.Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. AND Molecular Immunology Research Center, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, IranPreterm birth means the birth before thirty seven week of pregnancy that causes a lot of complications for the baby. Variety factors are suggested to be involved in disease. In this study, we decided to evaluate haptoglobin (Hp) phenotypes association with clinical features of patients suffered from premature delivery to understand better the possible correlation of genetic and clinical features in this disease. This cross sectional analytic descriptive study has been carried out in two groups of 120 women, 60 with preterm and 60 with term labor. Patients were selected with previously diagnosed by a gynecologist with preterm birth in hospital during the study period. After performing diagnostic tests, the frequency of each haptoglobin phenotype in the two groups was analyzed using the X2 test and SPSS software. The maximum serum haptoglobin phenotype frequency in patients with Hp2-2, was 43 (71.7%) whereas in healthy individuals, 35 (58.3%). No statistically significant differences between the two groups was found (P=0.310). But based on some patients clinical features such as their history of preterm delivery, previous history of recurrent abortions and history of preterm delivery in their family, significant association was found with Hp2-2 compared with healthy control (P<0.003). This study showed that Hp2-2 phenotypes levels in the case group was higher than in control but the factors influencing the presence or absence of preterm labor is clinically various.https://acta.tums.ac.ir/index.php/acta/article/view/4393HaptoglobinPhenotypesPreterm labor |
| spellingShingle | Hossein Ali Khazaei Batoul Teymuri Alireza Nakhaei Mehdi Mohammadi Mehrangeez Noura Amin Khazaei Neda Tofiqh Nima Rezaei Association of Haptoglobin Phenotypes with Clinical Features of Preterm Labor Disease Acta Medica Iranica Haptoglobin Phenotypes Preterm labor |
| title | Association of Haptoglobin Phenotypes with Clinical Features of Preterm Labor Disease |
| title_full | Association of Haptoglobin Phenotypes with Clinical Features of Preterm Labor Disease |
| title_fullStr | Association of Haptoglobin Phenotypes with Clinical Features of Preterm Labor Disease |
| title_full_unstemmed | Association of Haptoglobin Phenotypes with Clinical Features of Preterm Labor Disease |
| title_short | Association of Haptoglobin Phenotypes with Clinical Features of Preterm Labor Disease |
| title_sort | association of haptoglobin phenotypes with clinical features of preterm labor disease |
| topic | Haptoglobin Phenotypes Preterm labor |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/4393 |
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