Fatty acid composition of brain glycolipids in Alzheimer's disease, senile dementia, and cerebrocortical atrophy
Quantitative fatty acid compositions are reported for human cerebral gray matter glycolipids (gangliosides, cerebrosides, and cerebroside sulfates) in Alzheimer's disease (presenile dementia) and related disorders of the central nervous system. Although the fatty acid compositions were generall...
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| Format: | Article |
| Language: | English |
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Elsevier
1968-03-01
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| Series: | Journal of Lipid Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520431219 |
| _version_ | 1818672931671113728 |
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| author | George D. Cherayil |
| author_facet | George D. Cherayil |
| author_sort | George D. Cherayil |
| collection | DOAJ |
| description | Quantitative fatty acid compositions are reported for human cerebral gray matter glycolipids (gangliosides, cerebrosides, and cerebroside sulfates) in Alzheimer's disease (presenile dementia) and related disorders of the central nervous system. Although the fatty acid compositions were generally similar to those of the controls, some significant differences were noted in Alzheimer's disease which were not found in the single samples of senile dementia and of senile cerebrocortical atrophy.In the ganglioside fatty acids, the percentage of palmitic acid was higher in all three cases of Alzheimer's disease than in the controls. In cerebrosides, the proportion of 2-hydroxy to nonhydroxy acids was slightly lower in Alzheimer's disease than in controls and the relative proportions of 2-hydroxystearic acid and 2-hydroxytricosenoic acid were slightly higher. In cerebroside sulfates, monounsaturated 2-hydroxy acids were lower in two of the samples with Alzheimer's disease. The results indicate possible effects of the degenerative changes in this disease on glycolipid metabolism. |
| first_indexed | 2024-12-17T07:47:44Z |
| format | Article |
| id | doaj.art-d58c9b50508c44569d7f6d95b3c64327 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-17T07:47:44Z |
| publishDate | 1968-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-d58c9b50508c44569d7f6d95b3c643272022-12-21T21:57:57ZengElsevierJournal of Lipid Research0022-22751968-03-0192207214Fatty acid composition of brain glycolipids in Alzheimer's disease, senile dementia, and cerebrocortical atrophyGeorge D. Cherayil0Department of Pathology, Marquette School of Medicine, Milwaukee, Wisconsin 53233Quantitative fatty acid compositions are reported for human cerebral gray matter glycolipids (gangliosides, cerebrosides, and cerebroside sulfates) in Alzheimer's disease (presenile dementia) and related disorders of the central nervous system. Although the fatty acid compositions were generally similar to those of the controls, some significant differences were noted in Alzheimer's disease which were not found in the single samples of senile dementia and of senile cerebrocortical atrophy.In the ganglioside fatty acids, the percentage of palmitic acid was higher in all three cases of Alzheimer's disease than in the controls. In cerebrosides, the proportion of 2-hydroxy to nonhydroxy acids was slightly lower in Alzheimer's disease than in controls and the relative proportions of 2-hydroxystearic acid and 2-hydroxytricosenoic acid were slightly higher. In cerebroside sulfates, monounsaturated 2-hydroxy acids were lower in two of the samples with Alzheimer's disease. The results indicate possible effects of the degenerative changes in this disease on glycolipid metabolism.http://www.sciencedirect.com/science/article/pii/S0022227520431219Alzheimer's diseasesenile dementiacerebrocortical atrophyglycolipidsgangliosidescerebrosides |
| spellingShingle | George D. Cherayil Fatty acid composition of brain glycolipids in Alzheimer's disease, senile dementia, and cerebrocortical atrophy Journal of Lipid Research Alzheimer's disease senile dementia cerebrocortical atrophy glycolipids gangliosides cerebrosides |
| title | Fatty acid composition of brain glycolipids in Alzheimer's disease, senile dementia, and cerebrocortical atrophy |
| title_full | Fatty acid composition of brain glycolipids in Alzheimer's disease, senile dementia, and cerebrocortical atrophy |
| title_fullStr | Fatty acid composition of brain glycolipids in Alzheimer's disease, senile dementia, and cerebrocortical atrophy |
| title_full_unstemmed | Fatty acid composition of brain glycolipids in Alzheimer's disease, senile dementia, and cerebrocortical atrophy |
| title_short | Fatty acid composition of brain glycolipids in Alzheimer's disease, senile dementia, and cerebrocortical atrophy |
| title_sort | fatty acid composition of brain glycolipids in alzheimer s disease senile dementia and cerebrocortical atrophy |
| topic | Alzheimer's disease senile dementia cerebrocortical atrophy glycolipids gangliosides cerebrosides |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520431219 |
| work_keys_str_mv | AT georgedcherayil fattyacidcompositionofbrainglycolipidsinalzheimersdiseaseseniledementiaandcerebrocorticalatrophy |