Risk factors for acquisition of scrub typhus in children admitted to a tertiary centre and its surrounding districts in South India: a case control study
Abstract Background Scrub typhus is a mite borne zoonosis common in the tropics with no good preventive strategy. Children are also affected leading to considerable morbidity and mortality. We conducted a case control study and a vector survey to determine the risk factors for acquisition of scrub t...
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| Format: | Article |
| Language: | English |
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BMC
2019-07-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | http://link.springer.com/article/10.1186/s12879-019-4299-2 |
| _version_ | 1818858961076486144 |
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| author | Winsley Rose Gagandeep Kang Valsan Philip Verghese Sadanandane Candassamy Prasanna Samuel John Jude Antony Prakash Jayaprakash Muliyil |
| author_facet | Winsley Rose Gagandeep Kang Valsan Philip Verghese Sadanandane Candassamy Prasanna Samuel John Jude Antony Prakash Jayaprakash Muliyil |
| author_sort | Winsley Rose |
| collection | DOAJ |
| description | Abstract Background Scrub typhus is a mite borne zoonosis common in the tropics with no good preventive strategy. Children are also affected leading to considerable morbidity and mortality. We conducted a case control study and a vector survey to determine the risk factors for acquisition of scrub typhus. Methods A case control study with a 1:2 case control ratio was conducted over a 2 year period at a tertiary care centre and its surrounding districts in South India. Cases were children < 15 years with confirmed scrub typhus. Controls were age and locality matched community controls without fever. Demographic, environmental and behavioural risk factors were obtained in cases and controls by an interview and an environmental survey. A vector survey was also undertaken in the immediate vicinity of the cases. Results Case Control study: 101 cases and 167 controls were analysed. On multivariate analysis, significant association was observed with environmental factors such as the presence of a water body within 100 m of the house (OR 3.56(1.36,9.75); p 0.011), cooking outside the house (OR 5.61 (1.51,23.01); p 0.011), owning pets (OR 3.33(1.16,9.09); p 0.031), and the presence of bushes within 5 m of the house (OR 2.78 (1.11,7.69); p 0.033). Of the behavioural factors, the child going to school by a vehicle (OR 3.12 (2.29,8.37); p 0.006) was associated with an increased risk. Drying clothes on a clothesline showed a trend towards protection from acquiring scrub typhus (OR 0.31 (0.08, 1.08); p 0.077). Vector survey:26 rodents were trapped in as many houses. Trombiculid mites were isolated in 24 houses with 9(34.6%) being able to transmit scrub typhus. 254 trombiculid mites belonging to four species and two genera were collected. Leptotrombidium deliense, (33.5%). Schoengastiella ligula, (11.0%) of the total mite specimens collected. S. ligula always co-existed with L. deliense. The estimated Chigger index for Leptotrombidium deliense and Schoengastiella ligula was 3.27and 1.08 per animal respectively. Conclusions Our study highlights risk factors for scrub typhus, some of which may be modifiable. A clean peri-domestic environment free of vegetation, drying clothes on a clothesline and cooking indoors may decrease the risk of scrub typhus. |
| first_indexed | 2024-12-19T09:04:36Z |
| format | Article |
| id | doaj.art-d58cbac241d5461eae7d863de3ac2839 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-19T09:04:36Z |
| publishDate | 2019-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-d58cbac241d5461eae7d863de3ac28392022-12-21T20:28:24ZengBMCBMC Infectious Diseases1471-23342019-07-011911810.1186/s12879-019-4299-2Risk factors for acquisition of scrub typhus in children admitted to a tertiary centre and its surrounding districts in South India: a case control studyWinsley Rose0Gagandeep Kang1Valsan Philip Verghese2Sadanandane Candassamy3Prasanna Samuel4John Jude Antony Prakash5Jayaprakash Muliyil6Department of Pediatrics, Christian Medical CollegeDepartment of Gastrointestinal Sciences, Christian Medical CollegeDepartment of Pediatrics, Christian Medical CollegeDepartment of Health Research, Vector Control Research CentreDepartment of Biostatistics, Christian Medical CollegeDepartment of Microbiology, Christian Medical CollegeDepartment of Gastrointestinal Sciences, Christian Medical CollegeAbstract Background Scrub typhus is a mite borne zoonosis common in the tropics with no good preventive strategy. Children are also affected leading to considerable morbidity and mortality. We conducted a case control study and a vector survey to determine the risk factors for acquisition of scrub typhus. Methods A case control study with a 1:2 case control ratio was conducted over a 2 year period at a tertiary care centre and its surrounding districts in South India. Cases were children < 15 years with confirmed scrub typhus. Controls were age and locality matched community controls without fever. Demographic, environmental and behavioural risk factors were obtained in cases and controls by an interview and an environmental survey. A vector survey was also undertaken in the immediate vicinity of the cases. Results Case Control study: 101 cases and 167 controls were analysed. On multivariate analysis, significant association was observed with environmental factors such as the presence of a water body within 100 m of the house (OR 3.56(1.36,9.75); p 0.011), cooking outside the house (OR 5.61 (1.51,23.01); p 0.011), owning pets (OR 3.33(1.16,9.09); p 0.031), and the presence of bushes within 5 m of the house (OR 2.78 (1.11,7.69); p 0.033). Of the behavioural factors, the child going to school by a vehicle (OR 3.12 (2.29,8.37); p 0.006) was associated with an increased risk. Drying clothes on a clothesline showed a trend towards protection from acquiring scrub typhus (OR 0.31 (0.08, 1.08); p 0.077). Vector survey:26 rodents were trapped in as many houses. Trombiculid mites were isolated in 24 houses with 9(34.6%) being able to transmit scrub typhus. 254 trombiculid mites belonging to four species and two genera were collected. Leptotrombidium deliense, (33.5%). Schoengastiella ligula, (11.0%) of the total mite specimens collected. S. ligula always co-existed with L. deliense. The estimated Chigger index for Leptotrombidium deliense and Schoengastiella ligula was 3.27and 1.08 per animal respectively. Conclusions Our study highlights risk factors for scrub typhus, some of which may be modifiable. A clean peri-domestic environment free of vegetation, drying clothes on a clothesline and cooking indoors may decrease the risk of scrub typhus.http://link.springer.com/article/10.1186/s12879-019-4299-2Scrub typhusChildrenRisk factorsMites |
| spellingShingle | Winsley Rose Gagandeep Kang Valsan Philip Verghese Sadanandane Candassamy Prasanna Samuel John Jude Antony Prakash Jayaprakash Muliyil Risk factors for acquisition of scrub typhus in children admitted to a tertiary centre and its surrounding districts in South India: a case control study BMC Infectious Diseases Scrub typhus Children Risk factors Mites |
| title | Risk factors for acquisition of scrub typhus in children admitted to a tertiary centre and its surrounding districts in South India: a case control study |
| title_full | Risk factors for acquisition of scrub typhus in children admitted to a tertiary centre and its surrounding districts in South India: a case control study |
| title_fullStr | Risk factors for acquisition of scrub typhus in children admitted to a tertiary centre and its surrounding districts in South India: a case control study |
| title_full_unstemmed | Risk factors for acquisition of scrub typhus in children admitted to a tertiary centre and its surrounding districts in South India: a case control study |
| title_short | Risk factors for acquisition of scrub typhus in children admitted to a tertiary centre and its surrounding districts in South India: a case control study |
| title_sort | risk factors for acquisition of scrub typhus in children admitted to a tertiary centre and its surrounding districts in south india a case control study |
| topic | Scrub typhus Children Risk factors Mites |
| url | http://link.springer.com/article/10.1186/s12879-019-4299-2 |
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