Ultrastructural analysis of the functional domains in FMRP using primary hippocampal mouse neurons

Ultrastructural analysis of the functional domains in FMRP using primary hippocampal mouse neurons

Fragile X syndrome is caused by lack of the protein FMRP. FMRP mediates mRNA binding, dendritic mRNA transport and translational control at spines. We examined the role of functional domains of FMRP in neuronal RNA-granule formation and dendritic transport using different FMRP variants, including th...

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Bibliographic Details
Main Authors: Josien Levenga, Ronald A.M. Buijsen, Maria Rifé, Hervé Moine, David L. Nelson, Ben A. Oostra, Rob Willemsen, Femke M.S. de Vrij
Format: Article
Language:English
Published: Elsevier 2009-08-01
Series:Neurobiology of Disease
Subjects:
Fragile X syndrome
FMRP
Fmr1
mRNA transport
FXR2P
RNA-granules
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109001016

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