Characterizing the Interplay of Lymphocytes in Graves’ Disease

Characterizing the Interplay of Lymphocytes in Graves’ Disease

Graves’ disease (GD) is a thyroid-specific autoimmune disease with a high prevalence worldwide. The disease is primarily mediated by B cells, which produce autoantibodies against the thyroid-stimulating hormone receptor (TSHR), chronically stimulating it and leading to high levels of thyroid hormone...

Full description

Bibliographic Details
Main Authors:	Mackenzie Hansen, Abigail Cheever, K. Scott Weber, Kim L. O’Neill
Format:	Article
Language:	English
Published:	MDPI AG 2023-04-01
Series:	International Journal of Molecular Sciences
Subjects:	Graves’ disease (GD) thyroid-stimulating hormone receptor (TSHR) autoimmune autoreactive B cell autoreactive T cell anti-TSHR autoantibody
Online Access:	https://www.mdpi.com/1422-0067/24/7/6835

Similar Items

TSHR169 Antigen Specifically Binds to the Thyroid-stimulating Autoantibody, Representing an Effective Biomarker for Graves’ Disease
by: Zulkarnain Zulkarnain, et al.
Published: (2019-03-01)

Is There Evidence for IGF1R-Stimulating Abs in Graves’ Orbitopathy Pathogenesis?
by: Christine C. Krieger, et al.
Published: (2020-09-01)

Bioassays for TSH receptor autoantibodies, from FRTL-5 cells to TSH receptor–LH/CG receptor chimeras: the contribution of Leonard D. Kohn
by: Cesidio Giuliani, et al.
Published: (2016-07-01)

ELF3-induced miR-182 inhibits adipogenic differentiation in Graves’ orbitopathy by targeting thyrotropin receptor
by: Sha Wang, et al.
Published: (2023-01-01)

Chimeric antigen receptor T-cell therapy for relapsed and refractory thyroid cancer
by: Jing Ding, et al.
Published: (2022-09-01)

EVALUATION OF IMMUNOLOGICAL SHIFTS IN ADULTS AFTER IMMUNIZATION AGAINST INFLUENZA WITH A SUBUNIT-BASED, ABSORBED MONOVALENT VACCINE STRAIN A/CALIFORNIA/7/2009/(H1N1)
by: M. P. Kostinov, et al.
Published: (2014-07-01)

Immunoglobulin E and G autoantibodies against eosinophil proteins in children and adults with asthma and healthy subjects
by: Jorge Sánchez, MD, MSc, EAC, PhD, et al.
Published: (2023-02-01)

Determining specific thyroid transcripts in peripheral blood: A single center study experience
by: Makazlieva T, et al.
Published: (2018-12-01)

Sustained effects on immune cell subsets and autoreactivity in multiple sclerosis patients treated with oral cladribine
by: Rikke Holm Hansen, et al.
Published: (2024-02-01)

B Cell Activation and Escape of Tolerance Checkpoints: Recent Insights from Studying Autoreactive B Cells
by: Carlo G. Bonasia, et al.
Published: (2021-05-01)

Risk of malignancy in cytologically indeterminate thyroid nodules harboring thyroid stimulating hormone receptor mutations
by: Dorota Whitmer, et al.
Published: (2022-12-01)

Autoantibodies as Biomarker and Therapeutic Target in Systemic Sclerosis
by: Hanna Graßhoff, et al.
Published: (2022-09-01)

Autoreactive T-Cells in Psoriasis: Are They Spoiled Tregs and Can Therapies Restore Their Functions?
by: Immacolata Pietraforte, et al.
Published: (2023-02-01)

Assessing the efficacy of various treatment regimens for patients with endocrine ophthalmopathy associated with Graves’ disease
by: Yu. V. Buldygina, et al.
Published: (2022-03-01)

Comparison of orbital fibroblasts from Graves’ ophthalmopathy and healthy control
by: Yu Wu, et al.
Published: (2024-04-01)

Application of single-cell RNA sequencing methods to develop B cell targeted treatments for autoimmunity
by: Catherine A. Nicholas, et al.
Published: (2023-07-01)

Attenuation of OX40 signaling suppression by age disrupts peripheral deletion of CD4+ T cells specific for the epidermal autoantigen desmoglein 3
by: Hisato Iriki, et al.
Published: (2023-06-01)

TSHRV656F Activating Variant of the Thyroid Stimulating Hormone Receptor Gene in Neonatal Onset Hyperthyroidism: A Case Review
by: Leman Kayaş, et al.
Published: (2022-03-01)

Familial non-autoimmune hyperthyroidism in family members across four generations due to a novel disease-causing variant in the thyrotropin receptor gene
by: Malej A, et al.
Published: (2021-03-01)

The Impact of the D727e Polymorphism has no Significant Role in Multi Nodular Goiter
by: Tug E., et al.
Published: (2012-12-01)

B cells in the balance: Offsetting self-reactivity avoidance with protection against foreign
by: Clara Young, et al.
Published: (2022-07-01)

Engineering chimeric autoantibody receptor T cells for targeted B cell depletion in multiple sclerosis model: An in-vitro study
by: Maryam Sahlolbei, et al.
Published: (2023-09-01)

IgE Autoreactivity in Atopic Dermatitis: Paving the Road for Autoimmune Diseases?
by: Christophe Pellefigues
Published: (2020-09-01)

Human Chorionic Gonadotropin Influences Systemic Autoimmune Responses
by: Alpana De, et al.
Published: (2018-12-01)

Editorial: News in Graves’ orbitopathy: patients management and treatments
by: Giulia Lanzolla, et al.
Published: (2023-08-01)

Autoreactivity of Broadly Neutralizing Influenza Human Antibodies to Human Tissues and Human Proteins
by: Surender Khurana, et al.
Published: (2020-10-01)

Hyperoxidized Species of Heme Have a Potent Capacity to Induce Autoreactivity of Human IgG Antibodies
by: Marie Wiatr, et al.
Published: (2023-02-01)

Smart and Multifunctional Materials and their possible application in façade systems
by: Miren Juaristi, et al.
Published: (2018-11-01)

Lineage Reconstruction of In Vitro Identified Antigen-Specific Autoreactive B Cells from Adaptive Immune Receptor Repertoires
by: Peter Blazso, et al.
Published: (2022-12-01)

DAMP-mediated inflammation and regulated cell death in immunoinflammatory rheumatic diseases
by: M. Z. Saidov
Published: (2023-02-01)

Clonal relationships of memory B cell subsets in autoimmune mice
by: Alaitz Aranburu, et al.
Published: (2023-03-01)

Central TSH Dysregulation in a Patient with Familial Non-Autoimmune Autosomal Dominant Hyperthyroidism Due to a Novel Thyroid-Stimulating Hormone Receptor Disease-Causing Variant
by: Jasna Suput Omladic, et al.
Published: (2021-02-01)

Analysis of chosen polymorphisms rs2476601 a/G – PTPN22, rs1990760 C/T – IFIH1, rs179247 a/G – TSHR in pathogenesis of autoimmune thyroid diseases in children
by: Marta Rydzewska, et al.
Published: (2018-05-01)

Autoinmunidad tiroidea Nuevos conceptos en la fisiopatología
by: Arturo Orrego Monsalve
Published: (2017-03-01)

A Germline-Encoded Structural Arginine Trap Underlies the Anti-DNA Reactivity of a Murine V Gene Segment
by: Ronny Petterson dos Santos Araújo, et al.
Published: (2021-04-01)

Editorial: Does selection against autoreactive B cells limit affinity maturation to pathogens?
by: Marilyn Diaz, et al.
Published: (2023-10-01)

Autoreactive T Cells in Human Smokers Is Predictive of Clinical Outcome
by: Chuang eXu, et al.
Published: (2012-08-01)

Computational model of the full-length TSH receptor
by: Mihaly Mezei, et al.
Published: (2022-10-01)

MHC Class II Presentation in Autoimmunity
by: Irina A. Ishina, et al.
Published: (2023-01-01)

Efgartigimod, an FcRn antagonist, as a potential treatment for post COVID-19 syndrome
by: Sandra E. Reznik, et al.
Published: (2023-06-01)