Upregulation of Cysteine Protease Cathepsin X in the 6-Hydroxydopamine Model of Parkinson’s Disease

Upregulation of Cysteine Protease Cathepsin X in the 6-Hydroxydopamine Model of Parkinson’s Disease

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by loss of midbrain dopaminergic neurons in the substantia nigra pars compacta (SNc). In vitro, a contribution to neuroinflammation and neurotoxicity has been shown for the lysosomal protease cathepsin X; however, its expression...

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Bibliographic Details
Main Authors: Anja Pišlar, Larisa Tratnjek, Gordana Glavan, Marko Živin, Janko Kos
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
6-hydroxydopamine
cathepsin X
dopaminergic neurons
glial cells
neurodegeneration
Parkinson’s disease
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00412/full

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