T Cell Immunity in Human Papillomavirus-Related Cutaneous Squamous Cell Carcinoma—A Systematic Review
Cutaneous squamous cell carcinoma (cSCC) is an invasive malignancy that disproportionately afflicts immunosuppressed individuals. The close associations of cSCC with immunosuppression and human papillomavirus (HPV) infection beget the question of how these three entities are intertwined in carcinoge...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/14/5/473 |
| _version_ | 1797264745761341440 |
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| author | Shi Huan Tay Choon Chiat Oh |
| author_facet | Shi Huan Tay Choon Chiat Oh |
| author_sort | Shi Huan Tay |
| collection | DOAJ |
| description | Cutaneous squamous cell carcinoma (cSCC) is an invasive malignancy that disproportionately afflicts immunosuppressed individuals. The close associations of cSCC with immunosuppression and human papillomavirus (HPV) infection beget the question of how these three entities are intertwined in carcinogenesis. By exploring the role of T cell immunity in HPV-related cSCC based on the existing literature, we found that the loss of T cell immunity in the background of β-HPV infection promotes cSCC initiation following exposure to environmental carcinogens or chronic trauma. This highlights the potential of developing T-cell centred therapeutic and preventive strategies for populations with increased cSCC risk. |
| first_indexed | 2024-04-25T00:33:47Z |
| format | Article |
| id | doaj.art-d590a8a672294bc1bf7ef0275f96c5ef |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-04-25T00:33:47Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-d590a8a672294bc1bf7ef0275f96c5ef2024-03-12T16:41:53ZengMDPI AGDiagnostics2075-44182024-02-0114547310.3390/diagnostics14050473T Cell Immunity in Human Papillomavirus-Related Cutaneous Squamous Cell Carcinoma—A Systematic ReviewShi Huan Tay0Choon Chiat Oh1Duke-NUS Medical School, Singapore 169857, SingaporeDuke-NUS Medical School, Singapore 169857, SingaporeCutaneous squamous cell carcinoma (cSCC) is an invasive malignancy that disproportionately afflicts immunosuppressed individuals. The close associations of cSCC with immunosuppression and human papillomavirus (HPV) infection beget the question of how these three entities are intertwined in carcinogenesis. By exploring the role of T cell immunity in HPV-related cSCC based on the existing literature, we found that the loss of T cell immunity in the background of β-HPV infection promotes cSCC initiation following exposure to environmental carcinogens or chronic trauma. This highlights the potential of developing T-cell centred therapeutic and preventive strategies for populations with increased cSCC risk.https://www.mdpi.com/2075-4418/14/5/473cutaneous squamous cell carcinomahuman papillomavirusT cellimmunosuppressionanimal model |
| spellingShingle | Shi Huan Tay Choon Chiat Oh T Cell Immunity in Human Papillomavirus-Related Cutaneous Squamous Cell Carcinoma—A Systematic Review Diagnostics cutaneous squamous cell carcinoma human papillomavirus T cell immunosuppression animal model |
| title | T Cell Immunity in Human Papillomavirus-Related Cutaneous Squamous Cell Carcinoma—A Systematic Review |
| title_full | T Cell Immunity in Human Papillomavirus-Related Cutaneous Squamous Cell Carcinoma—A Systematic Review |
| title_fullStr | T Cell Immunity in Human Papillomavirus-Related Cutaneous Squamous Cell Carcinoma—A Systematic Review |
| title_full_unstemmed | T Cell Immunity in Human Papillomavirus-Related Cutaneous Squamous Cell Carcinoma—A Systematic Review |
| title_short | T Cell Immunity in Human Papillomavirus-Related Cutaneous Squamous Cell Carcinoma—A Systematic Review |
| title_sort | t cell immunity in human papillomavirus related cutaneous squamous cell carcinoma a systematic review |
| topic | cutaneous squamous cell carcinoma human papillomavirus T cell immunosuppression animal model |
| url | https://www.mdpi.com/2075-4418/14/5/473 |
| work_keys_str_mv | AT shihuantay tcellimmunityinhumanpapillomavirusrelatedcutaneoussquamouscellcarcinomaasystematicreview AT choonchiatoh tcellimmunityinhumanpapillomavirusrelatedcutaneoussquamouscellcarcinomaasystematicreview |