Two-Component System Sensor Kinases from Asgardian Archaea May Be Witnesses to Eukaryotic Cell Evolution
The signal transduction paradigm in bacteria involves two-component systems (TCSs). <i>Asgardarchaeota</i> are archaea that may have originated the current eukaryotic lifeforms. Most research on these archaea has focused on eukaryotic-like features, such as genes involved in phagocytosis...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/13/5042 |
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| author | Felipe Padilla-Vaca Javier de la Mora Rodolfo García-Contreras Jorge Humberto Ramírez-Prado Nayeli Alva-Murillo Sofia Fonseca-Yepez Isaac Serna-Gutiérrez Carolina Lisette Moreno-Galván José Manolo Montufar-Rodríguez Marcos Vicente-Gómez Ángeles Rangel-Serrano Naurú Idalia Vargas-Maya Bernardo Franco |
| author_facet | Felipe Padilla-Vaca Javier de la Mora Rodolfo García-Contreras Jorge Humberto Ramírez-Prado Nayeli Alva-Murillo Sofia Fonseca-Yepez Isaac Serna-Gutiérrez Carolina Lisette Moreno-Galván José Manolo Montufar-Rodríguez Marcos Vicente-Gómez Ángeles Rangel-Serrano Naurú Idalia Vargas-Maya Bernardo Franco |
| author_sort | Felipe Padilla-Vaca |
| collection | DOAJ |
| description | The signal transduction paradigm in bacteria involves two-component systems (TCSs). <i>Asgardarchaeota</i> are archaea that may have originated the current eukaryotic lifeforms. Most research on these archaea has focused on eukaryotic-like features, such as genes involved in phagocytosis, cytoskeleton structure, and vesicle trafficking. However, little attention has been given to specific prokaryotic features. Here, the sequence and predicted structural features of TCS sensor kinases analyzed from two metagenome assemblies and a genomic assembly from cultured Asgardian archaea are presented. The homology of the sensor kinases suggests the grouping <i>of Lokiarchaeum</i> closer to bacterial homologs. In contrast, one group from a <i>Lokiarchaeum</i> and a meta-genome assembly from <i>Candidatus Heimdallarchaeum</i> suggest the presence of a set of kinases separated from the typical bacterial TCS sensor kinases. AtoS and ArcB homologs were found in meta-genome assemblies along with defined domains for other well-characterized sensor kinases, suggesting the close link between these organisms and bacteria that may have resulted in the metabolic link to the establishment of symbiosis. Several kinases are predicted to be cytoplasmic; some contain several PAS domains. The data shown here suggest that TCS kinases in Asgardian bacteria are witnesses to the transition from bacteria to eukaryotic organisms. |
| first_indexed | 2024-03-11T01:34:35Z |
| format | Article |
| id | doaj.art-d5922d7b443b43fb9ab99d4f70b49a06 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T01:34:35Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d5922d7b443b43fb9ab99d4f70b49a062023-11-18T17:07:21ZengMDPI AGMolecules1420-30492023-06-012813504210.3390/molecules28135042Two-Component System Sensor Kinases from Asgardian Archaea May Be Witnesses to Eukaryotic Cell EvolutionFelipe Padilla-Vaca0Javier de la Mora1Rodolfo García-Contreras2Jorge Humberto Ramírez-Prado3Nayeli Alva-Murillo4Sofia Fonseca-Yepez5Isaac Serna-Gutiérrez6Carolina Lisette Moreno-Galván7José Manolo Montufar-Rodríguez8Marcos Vicente-Gómez9Ángeles Rangel-Serrano10Naurú Idalia Vargas-Maya11Bernardo Franco12Departamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta s/n, Guanajuato 36050, MexicoDepartamento de Genética Molecular, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Circuito Exterior s/n, Mexico City 04510, MexicoDepartamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City 04510, MexicoUnidad de Biotecnología, Centro de Investigación Científica de Yucatán, A. C., Mérida 97205, MexicoDepartamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta s/n, Guanajuato 36050, MexicoDepartamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta s/n, Guanajuato 36050, MexicoDepartamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta s/n, Guanajuato 36050, MexicoDepartamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta s/n, Guanajuato 36050, MexicoDepartamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta s/n, Guanajuato 36050, MexicoDepartamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta s/n, Guanajuato 36050, MexicoDepartamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta s/n, Guanajuato 36050, MexicoDepartamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta s/n, Guanajuato 36050, MexicoDepartamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta s/n, Guanajuato 36050, MexicoThe signal transduction paradigm in bacteria involves two-component systems (TCSs). <i>Asgardarchaeota</i> are archaea that may have originated the current eukaryotic lifeforms. Most research on these archaea has focused on eukaryotic-like features, such as genes involved in phagocytosis, cytoskeleton structure, and vesicle trafficking. However, little attention has been given to specific prokaryotic features. Here, the sequence and predicted structural features of TCS sensor kinases analyzed from two metagenome assemblies and a genomic assembly from cultured Asgardian archaea are presented. The homology of the sensor kinases suggests the grouping <i>of Lokiarchaeum</i> closer to bacterial homologs. In contrast, one group from a <i>Lokiarchaeum</i> and a meta-genome assembly from <i>Candidatus Heimdallarchaeum</i> suggest the presence of a set of kinases separated from the typical bacterial TCS sensor kinases. AtoS and ArcB homologs were found in meta-genome assemblies along with defined domains for other well-characterized sensor kinases, suggesting the close link between these organisms and bacteria that may have resulted in the metabolic link to the establishment of symbiosis. Several kinases are predicted to be cytoplasmic; some contain several PAS domains. The data shown here suggest that TCS kinases in Asgardian bacteria are witnesses to the transition from bacteria to eukaryotic organisms.https://www.mdpi.com/1420-3049/28/13/5042two-component systemssensor kinase<i>Asgardarchaeota</i>syntrophic metabolismeukaryotic origin |
| spellingShingle | Felipe Padilla-Vaca Javier de la Mora Rodolfo García-Contreras Jorge Humberto Ramírez-Prado Nayeli Alva-Murillo Sofia Fonseca-Yepez Isaac Serna-Gutiérrez Carolina Lisette Moreno-Galván José Manolo Montufar-Rodríguez Marcos Vicente-Gómez Ángeles Rangel-Serrano Naurú Idalia Vargas-Maya Bernardo Franco Two-Component System Sensor Kinases from Asgardian Archaea May Be Witnesses to Eukaryotic Cell Evolution Molecules two-component systems sensor kinase <i>Asgardarchaeota</i> syntrophic metabolism eukaryotic origin |
| title | Two-Component System Sensor Kinases from Asgardian Archaea May Be Witnesses to Eukaryotic Cell Evolution |
| title_full | Two-Component System Sensor Kinases from Asgardian Archaea May Be Witnesses to Eukaryotic Cell Evolution |
| title_fullStr | Two-Component System Sensor Kinases from Asgardian Archaea May Be Witnesses to Eukaryotic Cell Evolution |
| title_full_unstemmed | Two-Component System Sensor Kinases from Asgardian Archaea May Be Witnesses to Eukaryotic Cell Evolution |
| title_short | Two-Component System Sensor Kinases from Asgardian Archaea May Be Witnesses to Eukaryotic Cell Evolution |
| title_sort | two component system sensor kinases from asgardian archaea may be witnesses to eukaryotic cell evolution |
| topic | two-component systems sensor kinase <i>Asgardarchaeota</i> syntrophic metabolism eukaryotic origin |
| url | https://www.mdpi.com/1420-3049/28/13/5042 |
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