Platelet-rich fibrin as an autologous biomaterial for bone regeneration: mechanisms, applications, optimization
Platelet-rich fibrin, a classical autologous-derived bioactive material, consists of a fibrin scaffold and its internal loading of growth factors, platelets, and leukocytes, with the gradual degradation of the fibrin scaffold and the slow release of physiological doses of growth factors. PRF promote...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-04-01
|
| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1286035/full |
| _version_ | 1797205938129600512 |
|---|---|
| author | Kewen Jia Jiaqian You Yuemeng Zhu Minghui Li Sheng Chen Sicong Ren Siyu Chen Jingqi Zhang Hanchi Wang Yanmin Zhou |
| author_facet | Kewen Jia Jiaqian You Yuemeng Zhu Minghui Li Sheng Chen Sicong Ren Siyu Chen Jingqi Zhang Hanchi Wang Yanmin Zhou |
| author_sort | Kewen Jia |
| collection | DOAJ |
| description | Platelet-rich fibrin, a classical autologous-derived bioactive material, consists of a fibrin scaffold and its internal loading of growth factors, platelets, and leukocytes, with the gradual degradation of the fibrin scaffold and the slow release of physiological doses of growth factors. PRF promotes vascular regeneration, promotes the proliferation and migration of osteoblast-related cells such as mesenchymal cells, osteoblasts, and osteoclasts while having certain immunomodulatory and anti-bacterial effects. PRF has excellent osteogenic potential and has been widely used in the field of bone tissue engineering and dentistry. However, there are still some limitations of PRF, and the improvement of its biological properties is one of the most important issues to be solved. Therefore, it is often combined with bone tissue engineering scaffolds to enhance its mechanical properties and delay its degradation. In this paper, we present a systematic review of the development of platelet-rich derivatives, the structure and biological properties of PRF, osteogenic mechanisms, applications, and optimization to broaden their clinical applications and provide guidance for their clinical translation. |
| first_indexed | 2024-04-24T08:59:04Z |
| format | Article |
| id | doaj.art-d593ac7709d740be9053eae8217794aa |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-24T08:59:04Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-d593ac7709d740be9053eae8217794aa2024-04-16T04:34:08ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852024-04-011210.3389/fbioe.2024.12860351286035Platelet-rich fibrin as an autologous biomaterial for bone regeneration: mechanisms, applications, optimizationKewen JiaJiaqian YouYuemeng ZhuMinghui LiSheng ChenSicong RenSiyu ChenJingqi ZhangHanchi WangYanmin ZhouPlatelet-rich fibrin, a classical autologous-derived bioactive material, consists of a fibrin scaffold and its internal loading of growth factors, platelets, and leukocytes, with the gradual degradation of the fibrin scaffold and the slow release of physiological doses of growth factors. PRF promotes vascular regeneration, promotes the proliferation and migration of osteoblast-related cells such as mesenchymal cells, osteoblasts, and osteoclasts while having certain immunomodulatory and anti-bacterial effects. PRF has excellent osteogenic potential and has been widely used in the field of bone tissue engineering and dentistry. However, there are still some limitations of PRF, and the improvement of its biological properties is one of the most important issues to be solved. Therefore, it is often combined with bone tissue engineering scaffolds to enhance its mechanical properties and delay its degradation. In this paper, we present a systematic review of the development of platelet-rich derivatives, the structure and biological properties of PRF, osteogenic mechanisms, applications, and optimization to broaden their clinical applications and provide guidance for their clinical translation.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1286035/fullplatelet-rich derivativesplatelet-rich fibrinbone regenerationbone tissue engineeringdentistry |
| spellingShingle | Kewen Jia Jiaqian You Yuemeng Zhu Minghui Li Sheng Chen Sicong Ren Siyu Chen Jingqi Zhang Hanchi Wang Yanmin Zhou Platelet-rich fibrin as an autologous biomaterial for bone regeneration: mechanisms, applications, optimization Frontiers in Bioengineering and Biotechnology platelet-rich derivatives platelet-rich fibrin bone regeneration bone tissue engineering dentistry |
| title | Platelet-rich fibrin as an autologous biomaterial for bone regeneration: mechanisms, applications, optimization |
| title_full | Platelet-rich fibrin as an autologous biomaterial for bone regeneration: mechanisms, applications, optimization |
| title_fullStr | Platelet-rich fibrin as an autologous biomaterial for bone regeneration: mechanisms, applications, optimization |
| title_full_unstemmed | Platelet-rich fibrin as an autologous biomaterial for bone regeneration: mechanisms, applications, optimization |
| title_short | Platelet-rich fibrin as an autologous biomaterial for bone regeneration: mechanisms, applications, optimization |
| title_sort | platelet rich fibrin as an autologous biomaterial for bone regeneration mechanisms applications optimization |
| topic | platelet-rich derivatives platelet-rich fibrin bone regeneration bone tissue engineering dentistry |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1286035/full |
| work_keys_str_mv | AT kewenjia plateletrichfibrinasanautologousbiomaterialforboneregenerationmechanismsapplicationsoptimization AT jiaqianyou plateletrichfibrinasanautologousbiomaterialforboneregenerationmechanismsapplicationsoptimization AT yuemengzhu plateletrichfibrinasanautologousbiomaterialforboneregenerationmechanismsapplicationsoptimization AT minghuili plateletrichfibrinasanautologousbiomaterialforboneregenerationmechanismsapplicationsoptimization AT shengchen plateletrichfibrinasanautologousbiomaterialforboneregenerationmechanismsapplicationsoptimization AT sicongren plateletrichfibrinasanautologousbiomaterialforboneregenerationmechanismsapplicationsoptimization AT siyuchen plateletrichfibrinasanautologousbiomaterialforboneregenerationmechanismsapplicationsoptimization AT jingqizhang plateletrichfibrinasanautologousbiomaterialforboneregenerationmechanismsapplicationsoptimization AT hanchiwang plateletrichfibrinasanautologousbiomaterialforboneregenerationmechanismsapplicationsoptimization AT yanminzhou plateletrichfibrinasanautologousbiomaterialforboneregenerationmechanismsapplicationsoptimization |