Evaluation of Khaya gum (Khaya senegalensis) as a polymer in the formulation of floating in situ gels of metoprolol succinate
Metoprolol succinate, a β-selective adrenergic blocker, has a short half-life, low bioavailability, and high dosing frequency. In-situ gel drug delivery is a good approach to achieve sustained release for once-daily administration that will prolong drug retention time at the stomach and increase abs...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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University of Huddersfield Press
2023-04-01
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| Series: | British Journal of Pharmacy |
| Subjects: | |
| Online Access: | https://www.bjpharm.org.uk/article/id/1011/ |
| _version_ | 1797825344996114432 |
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| author | Adenike Okunlola Iyanu Abisoye Durodola |
| author_facet | Adenike Okunlola Iyanu Abisoye Durodola |
| author_sort | Adenike Okunlola |
| collection | DOAJ |
| description | Metoprolol succinate, a β-selective adrenergic blocker, has a short half-life, low bioavailability, and high dosing frequency. In-situ gel drug delivery is a good approach to achieve sustained release for once-daily administration that will prolong drug retention time at the stomach and increase absorption. Thus, the aim of the study is to formulate floating in-situ gel formulations of metoprolol succinate using Khaya gum (Khayasenegalensis, family Meliaceae) as a polymer. Khaya gum was characterized and used in formulating in situ gels of metoprolol succinate in comparison with Hydroxyl Propyl Methyl Cellulose (HPMC K15M) and Xanthan gum. The in-situ gel formulations were characterized for appearance, swelling, in-vitro buoyancy and in-vitro drug release. FTIR revealed major peaks characteristic of the gum. Khaya gum showed high swelling and good flow properties. In-situ gel formulations of metoprolol succinate containing Khaya were light brown with near neutral pH, higher swelling and a total floating time >24 h, comparable to those containing HPMC and Xanthan gums. Dissolution time t80 was 60.50 to >240 min with ranking Khaya <HPMC <Xanthan. Khaya gum provides a cheaper, suitable polymer for formulating floating in-situ gels with prolonged buoyancy and drug release. |
| first_indexed | 2024-03-13T10:52:43Z |
| format | Article |
| id | doaj.art-d5944d001e0c4a878d90a965badd7588 |
| institution | Directory Open Access Journal |
| issn | 2058-8356 |
| language | English |
| last_indexed | 2024-03-13T10:52:43Z |
| publishDate | 2023-04-01 |
| publisher | University of Huddersfield Press |
| record_format | Article |
| series | British Journal of Pharmacy |
| spelling | doaj.art-d5944d001e0c4a878d90a965badd75882023-05-17T09:17:40ZengUniversity of Huddersfield PressBritish Journal of Pharmacy2058-83562023-04-018110.5920/bjpharm.1011Evaluation of Khaya gum (Khaya senegalensis) as a polymer in the formulation of floating in situ gels of metoprolol succinateAdenike Okunlola 0Iyanu Abisoye Durodola1University of IbadanUniversity of IbadanMetoprolol succinate, a β-selective adrenergic blocker, has a short half-life, low bioavailability, and high dosing frequency. In-situ gel drug delivery is a good approach to achieve sustained release for once-daily administration that will prolong drug retention time at the stomach and increase absorption. Thus, the aim of the study is to formulate floating in-situ gel formulations of metoprolol succinate using Khaya gum (Khayasenegalensis, family Meliaceae) as a polymer. Khaya gum was characterized and used in formulating in situ gels of metoprolol succinate in comparison with Hydroxyl Propyl Methyl Cellulose (HPMC K15M) and Xanthan gum. The in-situ gel formulations were characterized for appearance, swelling, in-vitro buoyancy and in-vitro drug release. FTIR revealed major peaks characteristic of the gum. Khaya gum showed high swelling and good flow properties. In-situ gel formulations of metoprolol succinate containing Khaya were light brown with near neutral pH, higher swelling and a total floating time >24 h, comparable to those containing HPMC and Xanthan gums. Dissolution time t80 was 60.50 to >240 min with ranking Khaya <HPMC <Xanthan. Khaya gum provides a cheaper, suitable polymer for formulating floating in-situ gels with prolonged buoyancy and drug release.https://www.bjpharm.org.uk/article/id/1011/floating drug delivery systemin situ gelkhaya gummetoprolol succinatesustained release |
| spellingShingle | Adenike Okunlola Iyanu Abisoye Durodola Evaluation of Khaya gum (Khaya senegalensis) as a polymer in the formulation of floating in situ gels of metoprolol succinate British Journal of Pharmacy floating drug delivery system in situ gel khaya gum metoprolol succinate sustained release |
| title | Evaluation of Khaya gum (Khaya senegalensis) as a polymer in the formulation of floating in situ gels of metoprolol succinate |
| title_full | Evaluation of Khaya gum (Khaya senegalensis) as a polymer in the formulation of floating in situ gels of metoprolol succinate |
| title_fullStr | Evaluation of Khaya gum (Khaya senegalensis) as a polymer in the formulation of floating in situ gels of metoprolol succinate |
| title_full_unstemmed | Evaluation of Khaya gum (Khaya senegalensis) as a polymer in the formulation of floating in situ gels of metoprolol succinate |
| title_short | Evaluation of Khaya gum (Khaya senegalensis) as a polymer in the formulation of floating in situ gels of metoprolol succinate |
| title_sort | evaluation of khaya gum khaya senegalensis as a polymer in the formulation of floating in situ gels of metoprolol succinate |
| topic | floating drug delivery system in situ gel khaya gum metoprolol succinate sustained release |
| url | https://www.bjpharm.org.uk/article/id/1011/ |
| work_keys_str_mv | AT adenikeokunlola evaluationofkhayagumkhayasenegalensisasapolymerintheformulationoffloatinginsitugelsofmetoprololsuccinate AT iyanuabisoyedurodola evaluationofkhayagumkhayasenegalensisasapolymerintheformulationoffloatinginsitugelsofmetoprololsuccinate |