Correction for the Partial Volume Effects (PVE) in Nuclear Medicine Imaging: A Post-Reconstruction Analytic Method
Quantitative analyses in nuclear medicine are increasingly used, both for diagnostic and therapeutic purposes. The Partial Volume Effect (PVE) is the most important factor of loss of quantification in Nuclear Medicine, especially for evaluation in Region of Interest (ROI) smaller than the Full Width...
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| Format: | Article |
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MDPI AG
2021-07-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/14/6460 |
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| author | Fabio Di Martino Patrizio Barca Eleonora Bortoli Alessia Giuliano Duccio Volterrani |
| author_facet | Fabio Di Martino Patrizio Barca Eleonora Bortoli Alessia Giuliano Duccio Volterrani |
| author_sort | Fabio Di Martino |
| collection | DOAJ |
| description | Quantitative analyses in nuclear medicine are increasingly used, both for diagnostic and therapeutic purposes. The Partial Volume Effect (PVE) is the most important factor of loss of quantification in Nuclear Medicine, especially for evaluation in Region of Interest (ROI) smaller than the Full Width at Half Maximum (FWHM) of the PSF. The aim of this work is to present a new approach for the correction of PVE, using a post-reconstruction process starting from a mathematical expression, which only requires the knowledge of the FWHM of the final PSF of the imaging system used. After the presentation of the theoretical derivation, the experimental evaluation of this method is performed using a PET/CT hybrid system and acquiring the IEC NEMA phantom with six spherical “hot” ROIs (with diameters of 10, 13, 17, 22, 28, and 37 mm) and a homogeneous “colder” background. In order to evaluate the recovery of quantitative data, the effect of statistical noise (different acquisition times), tomographic reconstruction algorithm with and without time-of-flight (TOF) and different signal-to-background activity concentration ratio (3:1 and 10:1) was studied. The application of the corrective method allows recovering the loss of quantification due to PVE for all sizes of spheres acquired, with a final accuracy less than 17%, for lesion dimensions larger than two FWHM and for acquisition times equal to or greater than two minutes. |
| first_indexed | 2024-03-10T09:47:23Z |
| format | Article |
| id | doaj.art-d5967809e17b4ae190d4a77009a443ac |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T09:47:23Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-d5967809e17b4ae190d4a77009a443ac2023-11-22T03:10:03ZengMDPI AGApplied Sciences2076-34172021-07-011114646010.3390/app11146460Correction for the Partial Volume Effects (PVE) in Nuclear Medicine Imaging: A Post-Reconstruction Analytic MethodFabio Di Martino0Patrizio Barca1Eleonora Bortoli2Alessia Giuliano3Duccio Volterrani4Medical Physics Unit, University Hospital of Santa Chiara, 56126 Pisa, ItalyDepartment of Medical Physics, IRCCS AOUB, 40138 Bologna, ItalyMedical Physics Unit, University Hospital of Santa Chiara, 56126 Pisa, ItalyMedical Physics Unit, Hospital of San Luca, 55100 Lucca, ItalyNuclear Medicine Unit, University Hospital of Santa Chiara, 56126 Pisa, ItalyQuantitative analyses in nuclear medicine are increasingly used, both for diagnostic and therapeutic purposes. The Partial Volume Effect (PVE) is the most important factor of loss of quantification in Nuclear Medicine, especially for evaluation in Region of Interest (ROI) smaller than the Full Width at Half Maximum (FWHM) of the PSF. The aim of this work is to present a new approach for the correction of PVE, using a post-reconstruction process starting from a mathematical expression, which only requires the knowledge of the FWHM of the final PSF of the imaging system used. After the presentation of the theoretical derivation, the experimental evaluation of this method is performed using a PET/CT hybrid system and acquiring the IEC NEMA phantom with six spherical “hot” ROIs (with diameters of 10, 13, 17, 22, 28, and 37 mm) and a homogeneous “colder” background. In order to evaluate the recovery of quantitative data, the effect of statistical noise (different acquisition times), tomographic reconstruction algorithm with and without time-of-flight (TOF) and different signal-to-background activity concentration ratio (3:1 and 10:1) was studied. The application of the corrective method allows recovering the loss of quantification due to PVE for all sizes of spheres acquired, with a final accuracy less than 17%, for lesion dimensions larger than two FWHM and for acquisition times equal to or greater than two minutes.https://www.mdpi.com/2076-3417/11/14/6460partial volume effectquantitative analysispoint spread functionpost-reconstruction-correction-method |
| spellingShingle | Fabio Di Martino Patrizio Barca Eleonora Bortoli Alessia Giuliano Duccio Volterrani Correction for the Partial Volume Effects (PVE) in Nuclear Medicine Imaging: A Post-Reconstruction Analytic Method Applied Sciences partial volume effect quantitative analysis point spread function post-reconstruction-correction-method |
| title | Correction for the Partial Volume Effects (PVE) in Nuclear Medicine Imaging: A Post-Reconstruction Analytic Method |
| title_full | Correction for the Partial Volume Effects (PVE) in Nuclear Medicine Imaging: A Post-Reconstruction Analytic Method |
| title_fullStr | Correction for the Partial Volume Effects (PVE) in Nuclear Medicine Imaging: A Post-Reconstruction Analytic Method |
| title_full_unstemmed | Correction for the Partial Volume Effects (PVE) in Nuclear Medicine Imaging: A Post-Reconstruction Analytic Method |
| title_short | Correction for the Partial Volume Effects (PVE) in Nuclear Medicine Imaging: A Post-Reconstruction Analytic Method |
| title_sort | correction for the partial volume effects pve in nuclear medicine imaging a post reconstruction analytic method |
| topic | partial volume effect quantitative analysis point spread function post-reconstruction-correction-method |
| url | https://www.mdpi.com/2076-3417/11/14/6460 |
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