Current progress of oral site-specific dosage forms: Emphasis on gastroretentive drug delivery systems
The oral route of administration is considered the easiest, most convenient and widely used drug delivery route. One of the hardest challenges facing oral drug delivery systems (DDS) is the erratic absorption of drugs through the gastrointestinal tract (GIT). The conventional oral dosage forms usual...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ain Shams University
2022-12-01
|
| Series: | Archives of Pharmaceutical Sciences Ain Shams University |
| Subjects: | |
| Online Access: | https://aps.journals.ekb.eg/article_272700.html |
| _version_ | 1797853148768894976 |
|---|---|
| author | Walaa Elsherbeeny Riham El-Gogary Maha Nasr Omaima Sammour |
| author_facet | Walaa Elsherbeeny Riham El-Gogary Maha Nasr Omaima Sammour |
| author_sort | Walaa Elsherbeeny |
| collection | DOAJ |
| description | The oral route of administration is considered the easiest, most convenient and widely used drug delivery route. One of the hardest challenges facing oral drug delivery systems (DDS) is the erratic absorption of drugs through the gastrointestinal tract (GIT). The conventional oral dosage forms usually suffer from low bioavailability especially in case of drugs with narrow absorption window (NAW). The oral controlled release dosage forms could overcome the previous limitation by providing predicted and calculated drug release, resulting in improvement of the efficacy of drugs. One of the most promising types of oral controlled release dosage forms for this purpose is the gastro retentive drug delivery system (GRDDS), which was found to improve the gastric retention of the dosage form and maximize the absorption and bioavailability of the drugs with NAW. In this review, we summarize the different GRDDS techniques used for improving drug absorption, their methods of preparation, and their mechanisms of action. |
| first_indexed | 2024-04-09T19:45:53Z |
| format | Article |
| id | doaj.art-d597e4b2abd94c0492ed3605a1ed9d65 |
| institution | Directory Open Access Journal |
| issn | 2356-8380 2356-8399 |
| language | English |
| last_indexed | 2024-04-09T19:45:53Z |
| publishDate | 2022-12-01 |
| publisher | Ain Shams University |
| record_format | Article |
| series | Archives of Pharmaceutical Sciences Ain Shams University |
| spelling | doaj.art-d597e4b2abd94c0492ed3605a1ed9d652023-04-03T20:24:16ZengAin Shams UniversityArchives of Pharmaceutical Sciences Ain Shams University2356-83802356-83992022-12-01622123810.21608/APS.2022.168128.1101 Current progress of oral site-specific dosage forms: Emphasis on gastroretentive drug delivery systemsWalaa Elsherbeeny0Riham El-Gogary1Maha Nasr2Omaima Sammour3Central Administration of Operation, Department of Factory Inspection, Egyptian Drug Authority, Cairo, EgyptDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo 11566, EgyptDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo 11566, EgyptDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo 11566, EgyptThe oral route of administration is considered the easiest, most convenient and widely used drug delivery route. One of the hardest challenges facing oral drug delivery systems (DDS) is the erratic absorption of drugs through the gastrointestinal tract (GIT). The conventional oral dosage forms usually suffer from low bioavailability especially in case of drugs with narrow absorption window (NAW). The oral controlled release dosage forms could overcome the previous limitation by providing predicted and calculated drug release, resulting in improvement of the efficacy of drugs. One of the most promising types of oral controlled release dosage forms for this purpose is the gastro retentive drug delivery system (GRDDS), which was found to improve the gastric retention of the dosage form and maximize the absorption and bioavailability of the drugs with NAW. In this review, we summarize the different GRDDS techniques used for improving drug absorption, their methods of preparation, and their mechanisms of action.https://aps.journals.ekb.eg/article_272700.htmloral routecontrolled releasenarrow absorption windowgastroretentive delivery systemstablets |
| spellingShingle | Walaa Elsherbeeny Riham El-Gogary Maha Nasr Omaima Sammour Current progress of oral site-specific dosage forms: Emphasis on gastroretentive drug delivery systems Archives of Pharmaceutical Sciences Ain Shams University oral route controlled release narrow absorption window gastroretentive delivery systems tablets |
| title | Current progress of oral site-specific dosage forms: Emphasis on gastroretentive drug delivery systems |
| title_full | Current progress of oral site-specific dosage forms: Emphasis on gastroretentive drug delivery systems |
| title_fullStr | Current progress of oral site-specific dosage forms: Emphasis on gastroretentive drug delivery systems |
| title_full_unstemmed | Current progress of oral site-specific dosage forms: Emphasis on gastroretentive drug delivery systems |
| title_short | Current progress of oral site-specific dosage forms: Emphasis on gastroretentive drug delivery systems |
| title_sort | current progress of oral site specific dosage forms emphasis on gastroretentive drug delivery systems |
| topic | oral route controlled release narrow absorption window gastroretentive delivery systems tablets |
| url | https://aps.journals.ekb.eg/article_272700.html |
| work_keys_str_mv | AT walaaelsherbeeny currentprogressoforalsitespecificdosageformsemphasisongastroretentivedrugdeliverysystems AT rihamelgogary currentprogressoforalsitespecificdosageformsemphasisongastroretentivedrugdeliverysystems AT mahanasr currentprogressoforalsitespecificdosageformsemphasisongastroretentivedrugdeliverysystems AT omaimasammour currentprogressoforalsitespecificdosageformsemphasisongastroretentivedrugdeliverysystems |