Measuring NDC80 binding reveals the molecular basis of tension-dependent kinetochore-microtubule attachments

Measuring NDC80 binding reveals the molecular basis of tension-dependent kinetochore-microtubule attachments

Proper kinetochore-microtubule attachments, mediated by the NDC80 complex, are required for error-free chromosome segregation. Erroneous attachments are corrected by the tension dependence of kinetochore-microtubule interactions. Here, we present a method, based on fluorescence lifetime imaging micr...

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Bibliographic Details
Main Authors: Tae Yeon Yoo, Jeong-Mo Choi, William Conway, Che-Hang Yu, Rohit V Pappu, Daniel J Needleman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
kinetochore
NDC80 complex
Aurora B kinase
fluorescence Lifetime Imaging
tension sensing
Online Access:https://elifesciences.org/articles/36392

Internet

https://elifesciences.org/articles/36392

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