Endovascular image-guided sampling of tumor-draining veins provides an enriched source of oncological biomarkers
IntroductionCirculating tumor-derived biomarkers can potentially impact cancer management throughout the continuum of care. This small exploratory study aimed to assess the relative levels of such biomarkers in the tumor-draining vascular beds in patients with solid tumors compared to levels in thei...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.916196/full |
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| author | Anobel Tamrazi Srividya Sundaresan Aishwarya Gulati Frederick J. Tan Vibhor Wadhwa Bjarne R. Bartlett Luis A. Jr. Diaz |
| author_facet | Anobel Tamrazi Srividya Sundaresan Aishwarya Gulati Frederick J. Tan Vibhor Wadhwa Bjarne R. Bartlett Luis A. Jr. Diaz |
| author_sort | Anobel Tamrazi |
| collection | DOAJ |
| description | IntroductionCirculating tumor-derived biomarkers can potentially impact cancer management throughout the continuum of care. This small exploratory study aimed to assess the relative levels of such biomarkers in the tumor-draining vascular beds in patients with solid tumors compared to levels in their peripheral veins.MethodsUsing an endovascular image-guided approach, we obtained blood samples from peripheral veins and other vascular compartments–including the most proximal venous drainage from solid tumors–from a set of nine oncology patients with various primary and metastatic malignancies. We then interrogated these samples for a panel of oncological biomarkers, including circulating tumor cells (CTCs), exosome-derived microRNAs (miRNAs), circulating tumor DNA (ctDNA) mutations, and certain cancer-related proteins/biochemical markers.ResultsWe found substantially higher levels of CTCs, certain miRNAs, and specific ctDNA mutations in samples from vascular beds closer to the tumor compared with those from peripheral veins and also noted that some of these signals were altered by treatment procedures.DiscussionOur results indicate that tumor-proximal venous samples are highly enriched for some oncological biomarkers and may allow for more robust molecular analysis than peripheral vein samples. |
| first_indexed | 2024-04-09T23:52:58Z |
| format | Article |
| id | doaj.art-d59ad7738e504796842c253f6476a823 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-09T23:52:58Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-d59ad7738e504796842c253f6476a8232023-03-17T05:27:48ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-03-011310.3389/fonc.2023.916196916196Endovascular image-guided sampling of tumor-draining veins provides an enriched source of oncological biomarkersAnobel Tamrazi0Srividya Sundaresan1Aishwarya Gulati2Frederick J. Tan3Vibhor Wadhwa4Bjarne R. Bartlett5Luis A. Jr. Diaz6Division of Vascular and Interventional Radiology, Palo Alto Medical Foundation, Redwood City, CA, United StatesDepartment of Clinical Research, Dignity Health, Sequoia Hospital, Redwood City, CA, United StatesDepartment of Radiology, Thomas Jefferson University Hospital, Philadelphia, PA, United StatesDepartment of Embryology, Carnegie Institution, Baltimore, MD, United StatesDivision of Interventional Radiology, NewYork-Presbyterian/Weill Cornell Medical Center, New York, NY, United StatesDepartment of Molecular Biosciences and Bioengineering, University of Hawaíi at Mānoa, Honolulu, HI, United StatesDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United StatesIntroductionCirculating tumor-derived biomarkers can potentially impact cancer management throughout the continuum of care. This small exploratory study aimed to assess the relative levels of such biomarkers in the tumor-draining vascular beds in patients with solid tumors compared to levels in their peripheral veins.MethodsUsing an endovascular image-guided approach, we obtained blood samples from peripheral veins and other vascular compartments–including the most proximal venous drainage from solid tumors–from a set of nine oncology patients with various primary and metastatic malignancies. We then interrogated these samples for a panel of oncological biomarkers, including circulating tumor cells (CTCs), exosome-derived microRNAs (miRNAs), circulating tumor DNA (ctDNA) mutations, and certain cancer-related proteins/biochemical markers.ResultsWe found substantially higher levels of CTCs, certain miRNAs, and specific ctDNA mutations in samples from vascular beds closer to the tumor compared with those from peripheral veins and also noted that some of these signals were altered by treatment procedures.DiscussionOur results indicate that tumor-proximal venous samples are highly enriched for some oncological biomarkers and may allow for more robust molecular analysis than peripheral vein samples.https://www.frontiersin.org/articles/10.3389/fonc.2023.916196/fulltumor-draining veintumor-proximaloncological biomarkercirculating tumor cell (CTC)microRNA (miRNA)circulating tumor DNA (ctDNA) |
| spellingShingle | Anobel Tamrazi Srividya Sundaresan Aishwarya Gulati Frederick J. Tan Vibhor Wadhwa Bjarne R. Bartlett Luis A. Jr. Diaz Endovascular image-guided sampling of tumor-draining veins provides an enriched source of oncological biomarkers Frontiers in Oncology tumor-draining vein tumor-proximal oncological biomarker circulating tumor cell (CTC) microRNA (miRNA) circulating tumor DNA (ctDNA) |
| title | Endovascular image-guided sampling of tumor-draining veins provides an enriched source of oncological biomarkers |
| title_full | Endovascular image-guided sampling of tumor-draining veins provides an enriched source of oncological biomarkers |
| title_fullStr | Endovascular image-guided sampling of tumor-draining veins provides an enriched source of oncological biomarkers |
| title_full_unstemmed | Endovascular image-guided sampling of tumor-draining veins provides an enriched source of oncological biomarkers |
| title_short | Endovascular image-guided sampling of tumor-draining veins provides an enriched source of oncological biomarkers |
| title_sort | endovascular image guided sampling of tumor draining veins provides an enriched source of oncological biomarkers |
| topic | tumor-draining vein tumor-proximal oncological biomarker circulating tumor cell (CTC) microRNA (miRNA) circulating tumor DNA (ctDNA) |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.916196/full |
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