Effects of Low-Dose Citicoline on the Electrical Conduction Function of the Crushed Sciatic Nerve of Rats
Introduction: Citicoline has therapeutic and beneficial effects in a variety of neurologic disorders and neurodegenerative diseases. The aim of this study was to examine the beneficial effects of low doses of citicoline for the early period of administration in rat sciatic nerve crush injury by usin...
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| Format: | Article |
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Karger Publishers
2023-07-01
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| Series: | Dubai Medical Journal |
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| Online Access: | https://beta.karger.com/Article/FullText/530762 |
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| author | Serife Gökçe Çalışkan Özlem Bozkurt Girit Mehmet Dinçer Bilgin |
| author_facet | Serife Gökçe Çalışkan Özlem Bozkurt Girit Mehmet Dinçer Bilgin |
| author_sort | Serife Gökçe Çalışkan |
| collection | DOAJ |
| description | Introduction: Citicoline has therapeutic and beneficial effects in a variety of neurologic disorders and neurodegenerative diseases. The aim of this study was to examine the beneficial effects of low doses of citicoline for the early period of administration in rat sciatic nerve crush injury by using electrophysiological and biochemical approaches. Methods: Thirty-two adult male Wistar rats were divided into four groups (n = 8 in each) and treated as follows: sham-operated (intact, saline), control (crushed sciatic nerve, saline), 50C (crushed sciatic nerve, 50 mg/kg citicoline), and 250C (crushed sciatic nerve, 250 mg/kg citicoline). At the end of the 7-day experimental period, motor nerve conduction velocities (MNCVs) were determined using in vivo electrodes and fresh rat blood was collected for biochemical analysis. Results: MNCVs were significantly reduced in crushed sciatic nerve of rats but significantly increased after 7 days of citicoline administration. Improved electrophysiological recovery in the citicoline groups was significant when compared to the control group. In addition, citicoline exacerbated the decrease in total glutathione level and glutathione reductase and catalase activities but decreased malondialdehyde levels compared to the control group. Conclusion: Results presented in this paper suggest that low doses of citicoline for the early period of administration have a promotional effect on improving the electrical conduction function of the sciatic nerve. |
| first_indexed | 2024-03-12T17:49:56Z |
| format | Article |
| id | doaj.art-d59bfbf2e6cc4d13b2c3b6cf2aca8e15 |
| institution | Directory Open Access Journal |
| issn | 2571-726X |
| language | English |
| last_indexed | 2024-03-12T17:49:56Z |
| publishDate | 2023-07-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Dubai Medical Journal |
| spelling | doaj.art-d59bfbf2e6cc4d13b2c3b6cf2aca8e152023-08-03T09:10:11ZengKarger PublishersDubai Medical Journal2571-726X2023-07-011610.1159/000530762530762Effects of Low-Dose Citicoline on the Electrical Conduction Function of the Crushed Sciatic Nerve of RatsSerife Gökçe Çalışkan0Özlem Bozkurt Girit1Mehmet Dinçer Bilgin2Department of Physics, Faculty of Science, Aydın Adnan Menderes University, Aydin, TurkeyDepartment of Biophysics, School of Medicine, Aydın Adnan Menderes University, Aydin, TurkeyDepartment of Biophysics, School of Medicine, Aydın Adnan Menderes University, Aydin, TurkeyIntroduction: Citicoline has therapeutic and beneficial effects in a variety of neurologic disorders and neurodegenerative diseases. The aim of this study was to examine the beneficial effects of low doses of citicoline for the early period of administration in rat sciatic nerve crush injury by using electrophysiological and biochemical approaches. Methods: Thirty-two adult male Wistar rats were divided into four groups (n = 8 in each) and treated as follows: sham-operated (intact, saline), control (crushed sciatic nerve, saline), 50C (crushed sciatic nerve, 50 mg/kg citicoline), and 250C (crushed sciatic nerve, 250 mg/kg citicoline). At the end of the 7-day experimental period, motor nerve conduction velocities (MNCVs) were determined using in vivo electrodes and fresh rat blood was collected for biochemical analysis. Results: MNCVs were significantly reduced in crushed sciatic nerve of rats but significantly increased after 7 days of citicoline administration. Improved electrophysiological recovery in the citicoline groups was significant when compared to the control group. In addition, citicoline exacerbated the decrease in total glutathione level and glutathione reductase and catalase activities but decreased malondialdehyde levels compared to the control group. Conclusion: Results presented in this paper suggest that low doses of citicoline for the early period of administration have a promotional effect on improving the electrical conduction function of the sciatic nerve.https://beta.karger.com/Article/FullText/530762citicolineelectromyographysciatic nerve crush injurymotor nerve conduction velocityneuroregeneration |
| spellingShingle | Serife Gökçe Çalışkan Özlem Bozkurt Girit Mehmet Dinçer Bilgin Effects of Low-Dose Citicoline on the Electrical Conduction Function of the Crushed Sciatic Nerve of Rats Dubai Medical Journal citicoline electromyography sciatic nerve crush injury motor nerve conduction velocity neuroregeneration |
| title | Effects of Low-Dose Citicoline on the Electrical Conduction Function of the Crushed Sciatic Nerve of Rats |
| title_full | Effects of Low-Dose Citicoline on the Electrical Conduction Function of the Crushed Sciatic Nerve of Rats |
| title_fullStr | Effects of Low-Dose Citicoline on the Electrical Conduction Function of the Crushed Sciatic Nerve of Rats |
| title_full_unstemmed | Effects of Low-Dose Citicoline on the Electrical Conduction Function of the Crushed Sciatic Nerve of Rats |
| title_short | Effects of Low-Dose Citicoline on the Electrical Conduction Function of the Crushed Sciatic Nerve of Rats |
| title_sort | effects of low dose citicoline on the electrical conduction function of the crushed sciatic nerve of rats |
| topic | citicoline electromyography sciatic nerve crush injury motor nerve conduction velocity neuroregeneration |
| url | https://beta.karger.com/Article/FullText/530762 |
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