Imaging Evaluation of Intervertebral Disc Degeneration and Painful Discs—Advances and Challenges in Quantitative MRI
In recent years, various quantitative and functional magnetic resonance imaging (MRI) sequences have been developed and used in clinical practice for the diagnosis of patients with low back pain (LBP). Until now, T2-weighted imaging (T2WI), a visual qualitative evaluation method, has been used to di...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/3/707 |
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| author | Shota Tamagawa Daisuke Sakai Hidetoshi Nojiri Masato Sato Muneaki Ishijima Masahiko Watanabe |
| author_facet | Shota Tamagawa Daisuke Sakai Hidetoshi Nojiri Masato Sato Muneaki Ishijima Masahiko Watanabe |
| author_sort | Shota Tamagawa |
| collection | DOAJ |
| description | In recent years, various quantitative and functional magnetic resonance imaging (MRI) sequences have been developed and used in clinical practice for the diagnosis of patients with low back pain (LBP). Until now, T2-weighted imaging (T2WI), a visual qualitative evaluation method, has been used to diagnose intervertebral disc (IVD) degeneration. However, this method has limitations in terms of reproducibility and inter-observer agreement. Moreover, T2WI observations do not directly relate with LBP. Therefore, new sequences such as T2 mapping, T1ρ mapping, and MR spectroscopy have been developed as alternative quantitative evaluation methods. These new quantitative MRIs can evaluate the anatomical and physiological changes of IVD degeneration in more detail than conventional T2WI. However, the values obtained from these quantitative MRIs still do not directly correlate with LBP, and there is a need for more widespread use of techniques that are more specific to clinical symptoms such as pain. In this paper, we review the state-of-the-art methodologies and future challenges of quantitative MRI as an imaging diagnostic tool for IVD degeneration and painful discs. |
| first_indexed | 2024-03-09T19:56:35Z |
| format | Article |
| id | doaj.art-d59dabe8075d403183de69886530ec16 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T19:56:35Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-d59dabe8075d403183de69886530ec162023-11-24T00:56:00ZengMDPI AGDiagnostics2075-44182022-03-0112370710.3390/diagnostics12030707Imaging Evaluation of Intervertebral Disc Degeneration and Painful Discs—Advances and Challenges in Quantitative MRIShota Tamagawa0Daisuke Sakai1Hidetoshi Nojiri2Masato Sato3Muneaki Ishijima4Masahiko Watanabe5Department of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, JapanDepartment of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Kanagawa, JapanDepartment of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, JapanDepartment of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Kanagawa, JapanDepartment of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, JapanDepartment of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Kanagawa, JapanIn recent years, various quantitative and functional magnetic resonance imaging (MRI) sequences have been developed and used in clinical practice for the diagnosis of patients with low back pain (LBP). Until now, T2-weighted imaging (T2WI), a visual qualitative evaluation method, has been used to diagnose intervertebral disc (IVD) degeneration. However, this method has limitations in terms of reproducibility and inter-observer agreement. Moreover, T2WI observations do not directly relate with LBP. Therefore, new sequences such as T2 mapping, T1ρ mapping, and MR spectroscopy have been developed as alternative quantitative evaluation methods. These new quantitative MRIs can evaluate the anatomical and physiological changes of IVD degeneration in more detail than conventional T2WI. However, the values obtained from these quantitative MRIs still do not directly correlate with LBP, and there is a need for more widespread use of techniques that are more specific to clinical symptoms such as pain. In this paper, we review the state-of-the-art methodologies and future challenges of quantitative MRI as an imaging diagnostic tool for IVD degeneration and painful discs.https://www.mdpi.com/2075-4418/12/3/707intervertebral disc degenerationdiscogenic low back painT2 mappingdiffusion-weighted MRIADC mappingT1ρ mapping |
| spellingShingle | Shota Tamagawa Daisuke Sakai Hidetoshi Nojiri Masato Sato Muneaki Ishijima Masahiko Watanabe Imaging Evaluation of Intervertebral Disc Degeneration and Painful Discs—Advances and Challenges in Quantitative MRI Diagnostics intervertebral disc degeneration discogenic low back pain T2 mapping diffusion-weighted MRI ADC mapping T1ρ mapping |
| title | Imaging Evaluation of Intervertebral Disc Degeneration and Painful Discs—Advances and Challenges in Quantitative MRI |
| title_full | Imaging Evaluation of Intervertebral Disc Degeneration and Painful Discs—Advances and Challenges in Quantitative MRI |
| title_fullStr | Imaging Evaluation of Intervertebral Disc Degeneration and Painful Discs—Advances and Challenges in Quantitative MRI |
| title_full_unstemmed | Imaging Evaluation of Intervertebral Disc Degeneration and Painful Discs—Advances and Challenges in Quantitative MRI |
| title_short | Imaging Evaluation of Intervertebral Disc Degeneration and Painful Discs—Advances and Challenges in Quantitative MRI |
| title_sort | imaging evaluation of intervertebral disc degeneration and painful discs advances and challenges in quantitative mri |
| topic | intervertebral disc degeneration discogenic low back pain T2 mapping diffusion-weighted MRI ADC mapping T1ρ mapping |
| url | https://www.mdpi.com/2075-4418/12/3/707 |
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