P53 regulates cellular redox state, ferroptosis and metabolism
The tumor protein P53 (TP53, or p53) has complex and at times seemingly contradictory roles in the regulation of metabolism and ferroptosis sensitivity. We find that the actions of p53 influence the redox state, which can trigger changes in redox-sensitive proteins, thereby modifying metabolic proce...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-03-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2021.1877076 |
| _version_ | 1797677110792290304 |
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| author | Julia I-Ju Leu Maureen E. Murphy Donna L. George |
| author_facet | Julia I-Ju Leu Maureen E. Murphy Donna L. George |
| author_sort | Julia I-Ju Leu |
| collection | DOAJ |
| description | The tumor protein P53 (TP53, or p53) has complex and at times seemingly contradictory roles in the regulation of metabolism and ferroptosis sensitivity. We find that the actions of p53 influence the redox state, which can trigger changes in redox-sensitive proteins, thereby modifying metabolic processes and response to ferroptosis. |
| first_indexed | 2024-03-11T22:40:15Z |
| format | Article |
| id | doaj.art-d59e66c600164c3ab3a02c6616a35f21 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:15Z |
| publishDate | 2021-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-d59e66c600164c3ab3a02c6616a35f212023-09-22T09:19:43ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562021-03-018210.1080/23723556.2021.18770761877076P53 regulates cellular redox state, ferroptosis and metabolismJulia I-Ju Leu0Maureen E. Murphy1Donna L. George2University of PennsylvaniaThe Wistar InstituteUniversity of PennsylvaniaThe tumor protein P53 (TP53, or p53) has complex and at times seemingly contradictory roles in the regulation of metabolism and ferroptosis sensitivity. We find that the actions of p53 influence the redox state, which can trigger changes in redox-sensitive proteins, thereby modifying metabolic processes and response to ferroptosis.http://dx.doi.org/10.1080/23723556.2021.1877076ferroptosisp53metabolismcysteine modificationredox signaling |
| spellingShingle | Julia I-Ju Leu Maureen E. Murphy Donna L. George P53 regulates cellular redox state, ferroptosis and metabolism Molecular & Cellular Oncology ferroptosis p53 metabolism cysteine modification redox signaling |
| title | P53 regulates cellular redox state, ferroptosis and metabolism |
| title_full | P53 regulates cellular redox state, ferroptosis and metabolism |
| title_fullStr | P53 regulates cellular redox state, ferroptosis and metabolism |
| title_full_unstemmed | P53 regulates cellular redox state, ferroptosis and metabolism |
| title_short | P53 regulates cellular redox state, ferroptosis and metabolism |
| title_sort | p53 regulates cellular redox state ferroptosis and metabolism |
| topic | ferroptosis p53 metabolism cysteine modification redox signaling |
| url | http://dx.doi.org/10.1080/23723556.2021.1877076 |
| work_keys_str_mv | AT juliaijuleu p53regulatescellularredoxstateferroptosisandmetabolism AT maureenemurphy p53regulatescellularredoxstateferroptosisandmetabolism AT donnalgeorge p53regulatescellularredoxstateferroptosisandmetabolism |