Seasonal Variations in the Diagnosis of Testicular Germ Cell Tumors: A National Cancer Registry Study in Austria
We conducted a retrospective National Cancer Registry study in Austria to assess a possible seasonal variation in the clinical diagnosis of testicular germ cell tumors (TGCT). In total, 3615 testicular cancer diagnoses were identified during an 11-year period from 2008 to 2018. Rate ratios for the m...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/21/5377 |
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| author | Gennadi Tulchiner Nina Staudacher Josef Fritz Monika Hackl Martin Pichler Maximilian Seles Shahrokh F. Shariat David D’Andrea Kilian Gust Walter Albrecht Karl Grubmüller Stephan Madersbacher Sebastian Graf Lukas Lusuardi Herbert Augustin Andreas Berger Wolfgang Loidl Wolfgang Horninger Renate Pichler |
| author_facet | Gennadi Tulchiner Nina Staudacher Josef Fritz Monika Hackl Martin Pichler Maximilian Seles Shahrokh F. Shariat David D’Andrea Kilian Gust Walter Albrecht Karl Grubmüller Stephan Madersbacher Sebastian Graf Lukas Lusuardi Herbert Augustin Andreas Berger Wolfgang Loidl Wolfgang Horninger Renate Pichler |
| author_sort | Gennadi Tulchiner |
| collection | DOAJ |
| description | We conducted a retrospective National Cancer Registry study in Austria to assess a possible seasonal variation in the clinical diagnosis of testicular germ cell tumors (TGCT). In total, 3615 testicular cancer diagnoses were identified during an 11-year period from 2008 to 2018. Rate ratios for the monthly number of TGCT diagnoses, as well as of seasons and half-years, were assessed using a quasi-Poisson model. We identified, for the first time, a statistically significant seasonal trend (<i>p</i> < 0.001) in the frequency of monthly newly diagnosed cases of TGCT. In detail, clear seasonal variations with a reduction in the tumor incidence during the summer months (Apr–Sep) and an increase during the winter months (Oct–Mar) were observed (<i>p</i> < 0.001). Focusing on seasonality, the incidence during the months of Oct–Dec (<i>p</i> = 0.008) and Jan–Mar (<i>p</i> < 0.001) was significantly higher compared to the months of Jul–Sep, respectively. Regarding histopathological features, there is a predominating incidence in the winter months compared to summer months, mainly concerning pure seminomas (<i>p</i> < 0.001), but not the non-seminoma or mixed TGCT groups. In conclusion, the incidence of TGCT diagnoses in Austria has a strong seasonal pattern, with the highest rate during the winter months. These findings may be explained by a delay of self-referral during the summer months. However, the hypothetical influence of vitamin D3 in testicular carcinogenesis underlying seasonal changes in TGCT diagnosis should be the focus of further research. |
| first_indexed | 2024-03-10T06:05:58Z |
| format | Article |
| id | doaj.art-d59ed494bb56415da028d81b3f9e5963 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T06:05:58Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-d59ed494bb56415da028d81b3f9e59632023-11-22T20:34:21ZengMDPI AGCancers2072-66942021-10-011321537710.3390/cancers13215377Seasonal Variations in the Diagnosis of Testicular Germ Cell Tumors: A National Cancer Registry Study in AustriaGennadi Tulchiner0Nina Staudacher1Josef Fritz2Monika Hackl3Martin Pichler4Maximilian Seles5Shahrokh F. Shariat6David D’Andrea7Kilian Gust8Walter Albrecht9Karl Grubmüller10Stephan Madersbacher11Sebastian Graf12Lukas Lusuardi13Herbert Augustin14Andreas Berger15Wolfgang Loidl16Wolfgang Horninger17Renate Pichler18Department of Urology, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, AustriaDepartment of Urology, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, AustriaDepartment of Medical Statistics, Informatics and Health Economics, Medical University of Innsbruck, Schöpfstraße 41, 6020 Innsbruck, AustriaAustrian National Cancer Registry, Statistics Austria, 1110 Vienna, AustriaResearch Unit of Non-Coding RNAs and Genome Editing in Cancer, Comprehensive Cancer Center Graz, Division of Clinical Oncology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, AustriaDepartment of Urology, Medical University of Graz, 8036 Graz, AustriaDepartment of Urology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Urology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Urology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Urology, Austria and Public Health Agency of Lower Austria, 2130 Mistelbach, AustriaDepartment of Urology and Andrology, University Hospital Krems, Karl Landsteiner University of Health Sciences, 3500 Krems, AustriaDepartment of Urology and Andrology, Kaiser-Franz-Josef Spital, 1100 Vienna, AustriaDepartment of Urology, Johannes Kepler University Linz, 4040 Linz, AustriaDepartment of Urology and Andrology, Paracelsus Medical University Salzburg, Müllner Hauptstrasse 48, 5020 Salzburg, AustriaDepartment of Urology, General Hospital of the City of Klagenfurt, 9020 Klagenfurt, AustriaDepartment of Urology, Academic Teaching Hospital Feldkirch, 6800 Feldkirch, AustriaDepartment of Urology, Ordensklinikum Linz GmbH Elisabethinen, 4020 Linz, AustriaDepartment of Urology, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, AustriaDepartment of Urology, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, AustriaWe conducted a retrospective National Cancer Registry study in Austria to assess a possible seasonal variation in the clinical diagnosis of testicular germ cell tumors (TGCT). In total, 3615 testicular cancer diagnoses were identified during an 11-year period from 2008 to 2018. Rate ratios for the monthly number of TGCT diagnoses, as well as of seasons and half-years, were assessed using a quasi-Poisson model. We identified, for the first time, a statistically significant seasonal trend (<i>p</i> < 0.001) in the frequency of monthly newly diagnosed cases of TGCT. In detail, clear seasonal variations with a reduction in the tumor incidence during the summer months (Apr–Sep) and an increase during the winter months (Oct–Mar) were observed (<i>p</i> < 0.001). Focusing on seasonality, the incidence during the months of Oct–Dec (<i>p</i> = 0.008) and Jan–Mar (<i>p</i> < 0.001) was significantly higher compared to the months of Jul–Sep, respectively. Regarding histopathological features, there is a predominating incidence in the winter months compared to summer months, mainly concerning pure seminomas (<i>p</i> < 0.001), but not the non-seminoma or mixed TGCT groups. In conclusion, the incidence of TGCT diagnoses in Austria has a strong seasonal pattern, with the highest rate during the winter months. These findings may be explained by a delay of self-referral during the summer months. However, the hypothetical influence of vitamin D3 in testicular carcinogenesis underlying seasonal changes in TGCT diagnosis should be the focus of further research.https://www.mdpi.com/2072-6694/13/21/5377detectiondiagnosisseasonal variationtesticular cancervitamin Dscreening |
| spellingShingle | Gennadi Tulchiner Nina Staudacher Josef Fritz Monika Hackl Martin Pichler Maximilian Seles Shahrokh F. Shariat David D’Andrea Kilian Gust Walter Albrecht Karl Grubmüller Stephan Madersbacher Sebastian Graf Lukas Lusuardi Herbert Augustin Andreas Berger Wolfgang Loidl Wolfgang Horninger Renate Pichler Seasonal Variations in the Diagnosis of Testicular Germ Cell Tumors: A National Cancer Registry Study in Austria Cancers detection diagnosis seasonal variation testicular cancer vitamin D screening |
| title | Seasonal Variations in the Diagnosis of Testicular Germ Cell Tumors: A National Cancer Registry Study in Austria |
| title_full | Seasonal Variations in the Diagnosis of Testicular Germ Cell Tumors: A National Cancer Registry Study in Austria |
| title_fullStr | Seasonal Variations in the Diagnosis of Testicular Germ Cell Tumors: A National Cancer Registry Study in Austria |
| title_full_unstemmed | Seasonal Variations in the Diagnosis of Testicular Germ Cell Tumors: A National Cancer Registry Study in Austria |
| title_short | Seasonal Variations in the Diagnosis of Testicular Germ Cell Tumors: A National Cancer Registry Study in Austria |
| title_sort | seasonal variations in the diagnosis of testicular germ cell tumors a national cancer registry study in austria |
| topic | detection diagnosis seasonal variation testicular cancer vitamin D screening |
| url | https://www.mdpi.com/2072-6694/13/21/5377 |
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