Polymer Tablet Matrix Systems for the Controlled Release of Dry <i>Betula pendula</i> Leaf Extract
The aim of the study was to develop polymer matrix tablets with modified release of dry <i>Betula pendula</i> leaf extract and to investigate basic parameters influencing the drug release pattern. To fully assess the statistical significance of the influence of the individual factors in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/15/17/3558 |
| _version_ | 1797582012364619776 |
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| author | Dimitar Penkov Paolina Lukova Hristo Manev Stela Dimitrova Margarita Kassarova |
| author_facet | Dimitar Penkov Paolina Lukova Hristo Manev Stela Dimitrova Margarita Kassarova |
| author_sort | Dimitar Penkov |
| collection | DOAJ |
| description | The aim of the study was to develop polymer matrix tablets with modified release of dry <i>Betula pendula</i> leaf extract and to investigate basic parameters influencing the drug release pattern. To fully assess the statistical significance of the influence of the individual factors in the tablet formulation development as well as the combination of them, Tukey’s tests and a complete 3<sup>3</sup> factor analysis of variance (ANOVA) were applied. The following three factors were studied at three levels (low, medium and high): influence of the hydrophobic/hydrophilic polymer ratio Ethylcellulose (EC)/Hydroxypropyl methylcellulose (HPMC) (40/60, 25/75 and 10/90), influence of HPMC molecular weight (500 kDa, 750 kDa and 1150 kDa), and influence of the compression force applied (1 t, 1.5 t and 2 t). The effect of these varied parameters on the drug release parameter t80 was evaluated statistically. Twenty-seven tablet models were formulated, including all possible combinations of the variables. The obtained drug release profiles demonstrated that a 25/75 (EC/HPMC) ratio was the most suitable for prolonging the release process. Increasing the molecular weight of HMPC from 500 kDa to 750–1150 kDa and applying higher compression force significantly influenced the studied t80 values and caused sustained drug release (t80 up to 7.97 h). The combination of the hydrophilic HPMC polymer with the hydrophobic EC can result in the formation of a promising drug-carrying matrix, offering effective control of the drug release process. |
| first_indexed | 2024-03-10T23:14:47Z |
| format | Article |
| id | doaj.art-d5a050b4e7be4ed98c0ee474c8290a34 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T23:14:47Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-d5a050b4e7be4ed98c0ee474c8290a342023-11-19T08:43:16ZengMDPI AGPolymers2073-43602023-08-011517355810.3390/polym15173558Polymer Tablet Matrix Systems for the Controlled Release of Dry <i>Betula pendula</i> Leaf ExtractDimitar Penkov0Paolina Lukova1Hristo Manev2Stela Dimitrova3Margarita Kassarova4Department of Pharmaceutical Sciences, Faculty of Pharmacy, Medical University of Plovdiv, 4002 Plovidv, BulgariaDepartment of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Plovdiv, 4002 Plovdiv, BulgariaDepartment of Medical Physics and Biophysics, Faculty of Pharmacy, Medical University of Plovdiv, 15A Vasil Aprilov Blvd, 4002 Plovdiv, BulgariaDepartment of Bioorganic Chemistry, Faculty of Pharmacy, Medical University of Plovdiv, 15A Vasil Aprilov Blvd, 4002 Plovdiv, BulgariaResearch Institute at Medical University of Plovdiv, 4002 Plovdiv, BulgariaThe aim of the study was to develop polymer matrix tablets with modified release of dry <i>Betula pendula</i> leaf extract and to investigate basic parameters influencing the drug release pattern. To fully assess the statistical significance of the influence of the individual factors in the tablet formulation development as well as the combination of them, Tukey’s tests and a complete 3<sup>3</sup> factor analysis of variance (ANOVA) were applied. The following three factors were studied at three levels (low, medium and high): influence of the hydrophobic/hydrophilic polymer ratio Ethylcellulose (EC)/Hydroxypropyl methylcellulose (HPMC) (40/60, 25/75 and 10/90), influence of HPMC molecular weight (500 kDa, 750 kDa and 1150 kDa), and influence of the compression force applied (1 t, 1.5 t and 2 t). The effect of these varied parameters on the drug release parameter t80 was evaluated statistically. Twenty-seven tablet models were formulated, including all possible combinations of the variables. The obtained drug release profiles demonstrated that a 25/75 (EC/HPMC) ratio was the most suitable for prolonging the release process. Increasing the molecular weight of HMPC from 500 kDa to 750–1150 kDa and applying higher compression force significantly influenced the studied t80 values and caused sustained drug release (t80 up to 7.97 h). The combination of the hydrophilic HPMC polymer with the hydrophobic EC can result in the formation of a promising drug-carrying matrix, offering effective control of the drug release process.https://www.mdpi.com/2073-4360/15/17/3558polymer tabletssustained releaseplant extractethylcellulosehydroxypropyl methylcellulose |
| spellingShingle | Dimitar Penkov Paolina Lukova Hristo Manev Stela Dimitrova Margarita Kassarova Polymer Tablet Matrix Systems for the Controlled Release of Dry <i>Betula pendula</i> Leaf Extract Polymers polymer tablets sustained release plant extract ethylcellulose hydroxypropyl methylcellulose |
| title | Polymer Tablet Matrix Systems for the Controlled Release of Dry <i>Betula pendula</i> Leaf Extract |
| title_full | Polymer Tablet Matrix Systems for the Controlled Release of Dry <i>Betula pendula</i> Leaf Extract |
| title_fullStr | Polymer Tablet Matrix Systems for the Controlled Release of Dry <i>Betula pendula</i> Leaf Extract |
| title_full_unstemmed | Polymer Tablet Matrix Systems for the Controlled Release of Dry <i>Betula pendula</i> Leaf Extract |
| title_short | Polymer Tablet Matrix Systems for the Controlled Release of Dry <i>Betula pendula</i> Leaf Extract |
| title_sort | polymer tablet matrix systems for the controlled release of dry i betula pendula i leaf extract |
| topic | polymer tablets sustained release plant extract ethylcellulose hydroxypropyl methylcellulose |
| url | https://www.mdpi.com/2073-4360/15/17/3558 |
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