Vascular Dysfunction in Diabetes and Obesity: Focus on TRP Channels
Transient receptor potential (TRP) superfamily consists of a diverse group of non-selective cation channels that has a wide tissue distribution and is involved in many physiological processes including sensory perception, secretion of hormones, vasoconstriction/vasorelaxation, and cell cycle modulat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.645109/full |
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| author | Raiana dos Anjos Moraes Raiana dos Anjos Moraes R. Clinton Webb Darízy Flávia Silva Darízy Flávia Silva |
| author_facet | Raiana dos Anjos Moraes Raiana dos Anjos Moraes R. Clinton Webb Darízy Flávia Silva Darízy Flávia Silva |
| author_sort | Raiana dos Anjos Moraes |
| collection | DOAJ |
| description | Transient receptor potential (TRP) superfamily consists of a diverse group of non-selective cation channels that has a wide tissue distribution and is involved in many physiological processes including sensory perception, secretion of hormones, vasoconstriction/vasorelaxation, and cell cycle modulation. In the blood vessels, TRP channels are present in endothelial cells, vascular smooth muscle cells, perivascular adipose tissue (PVAT) and perivascular sensory nerves, and these channels have been implicated in the regulation of vascular tone, vascular cell proliferation, vascular wall permeability and angiogenesis. Additionally, dysfunction of TRP channels is associated with cardiometabolic diseases, such as diabetes and obesity. Unfortunately, the prevalence of diabetes and obesity is rising worldwide, becoming an important public health problems. These conditions have been associated, highlighting that obesity is a risk factor for type 2 diabetes. As well, both cardiometabolic diseases have been linked to a common disorder, vascular dysfunction. In this review, we briefly consider general aspects of TRP channels, and we focus the attention on TRPC (canonical or classical), TRPV (vanilloid), TRPM (melastatin), and TRPML (mucolipin), which were shown to be involved in vascular alterations of diabetes and obesity or are potentially linked to vascular dysfunction. Therefore, elucidation of the functional and molecular mechanisms underlying the role of TRP channels in vascular dysfunction in diabetes and obesity is important for the prevention of vascular complications and end-organ damage, providing a further therapeutic target in the treatment of these metabolic diseases. |
| first_indexed | 2024-12-24T10:00:59Z |
| format | Article |
| id | doaj.art-d5a367eca42d46759cb586c334f58889 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-24T10:00:59Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-d5a367eca42d46759cb586c334f588892022-12-21T17:01:03ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-02-011210.3389/fphys.2021.645109645109Vascular Dysfunction in Diabetes and Obesity: Focus on TRP ChannelsRaiana dos Anjos Moraes0Raiana dos Anjos Moraes1R. Clinton Webb2Darízy Flávia Silva3Darízy Flávia Silva4Laboratory of Cardiovascular Physiology and Pharmacology, Institute of Health Sciences, Federal University of Bahia, Salvador, BrazilPostgraduate Course in Biotechnology in Health and Investigative Medicine, Gonçalo Moniz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, BrazilDepartment of Cell Biology and Anatomy and Cardiovascular Translational Research Center, University of South Carolina, Columbia, SC, United StatesLaboratory of Cardiovascular Physiology and Pharmacology, Institute of Health Sciences, Federal University of Bahia, Salvador, BrazilPostgraduate Course in Biotechnology in Health and Investigative Medicine, Gonçalo Moniz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, BrazilTransient receptor potential (TRP) superfamily consists of a diverse group of non-selective cation channels that has a wide tissue distribution and is involved in many physiological processes including sensory perception, secretion of hormones, vasoconstriction/vasorelaxation, and cell cycle modulation. In the blood vessels, TRP channels are present in endothelial cells, vascular smooth muscle cells, perivascular adipose tissue (PVAT) and perivascular sensory nerves, and these channels have been implicated in the regulation of vascular tone, vascular cell proliferation, vascular wall permeability and angiogenesis. Additionally, dysfunction of TRP channels is associated with cardiometabolic diseases, such as diabetes and obesity. Unfortunately, the prevalence of diabetes and obesity is rising worldwide, becoming an important public health problems. These conditions have been associated, highlighting that obesity is a risk factor for type 2 diabetes. As well, both cardiometabolic diseases have been linked to a common disorder, vascular dysfunction. In this review, we briefly consider general aspects of TRP channels, and we focus the attention on TRPC (canonical or classical), TRPV (vanilloid), TRPM (melastatin), and TRPML (mucolipin), which were shown to be involved in vascular alterations of diabetes and obesity or are potentially linked to vascular dysfunction. Therefore, elucidation of the functional and molecular mechanisms underlying the role of TRP channels in vascular dysfunction in diabetes and obesity is important for the prevention of vascular complications and end-organ damage, providing a further therapeutic target in the treatment of these metabolic diseases.https://www.frontiersin.org/articles/10.3389/fphys.2021.645109/fullTRP channelsvascular dysfunctiondiabetesobesityTRPCTRPM |
| spellingShingle | Raiana dos Anjos Moraes Raiana dos Anjos Moraes R. Clinton Webb Darízy Flávia Silva Darízy Flávia Silva Vascular Dysfunction in Diabetes and Obesity: Focus on TRP Channels Frontiers in Physiology TRP channels vascular dysfunction diabetes obesity TRPC TRPM |
| title | Vascular Dysfunction in Diabetes and Obesity: Focus on TRP Channels |
| title_full | Vascular Dysfunction in Diabetes and Obesity: Focus on TRP Channels |
| title_fullStr | Vascular Dysfunction in Diabetes and Obesity: Focus on TRP Channels |
| title_full_unstemmed | Vascular Dysfunction in Diabetes and Obesity: Focus on TRP Channels |
| title_short | Vascular Dysfunction in Diabetes and Obesity: Focus on TRP Channels |
| title_sort | vascular dysfunction in diabetes and obesity focus on trp channels |
| topic | TRP channels vascular dysfunction diabetes obesity TRPC TRPM |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2021.645109/full |
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