Per- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression
Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals utilized in various industrial settings and include products such as flame retardants, artificial film-forming foams, cosmetics, and non-stick cookware, among others. Epidemiological studies suggest a link between increased blood PFA...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/11/3902 |
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| author | Ozan Berk Imir Alanna Zoe Kaminsky Qian-Ying Zuo Yu-Jeh Liu Ratnakar Singh Michael J. Spinella Joseph Irudayaraj Wen-Yang Hu Gail S. Prins Zeynep Madak Erdogan |
| author_facet | Ozan Berk Imir Alanna Zoe Kaminsky Qian-Ying Zuo Yu-Jeh Liu Ratnakar Singh Michael J. Spinella Joseph Irudayaraj Wen-Yang Hu Gail S. Prins Zeynep Madak Erdogan |
| author_sort | Ozan Berk Imir |
| collection | DOAJ |
| description | Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals utilized in various industrial settings and include products such as flame retardants, artificial film-forming foams, cosmetics, and non-stick cookware, among others. Epidemiological studies suggest a link between increased blood PFAS levels and prostate cancer incidence, but the mechanism through which PFAS impact cancer development is unclear. To investigate the link between PFAS and prostate cancer, we evaluated the impact of metabolic alterations resulting from a high-fat diet combined with PFAS exposure on prostate tumor progression. We evaluated in vivo prostate cancer xenograft models exposed to perfluorooctane sulfonate (PFOS), a type of PFAS compound, and different diets to study the effects of PFAS on prostate cancer progression and metabolic activity. Metabolomics and transcriptomics were used to understand the metabolic landscape shifts upon PFAS exposure. We evaluated metabolic changes in benign or tumor cells that lead to epigenomic reprogramming and altered signaling, which ultimately increase tumorigenic risk and tumor aggressiveness. Our studies are the first in the field to provide new and clinically relevant insights regarding novel metabolic and epigenetic states as well as to support the future development of effective preventative and therapeutic strategies for PFAS-induced prostate cancers. Our findings enhance understanding of how PFAS synergize with high-fat diets to contribute to prostate cancer development and establish an important basis to mitigate PFAS exposure. |
| first_indexed | 2024-03-10T05:12:16Z |
| format | Article |
| id | doaj.art-d5a3a6ac6a5247f4b3b8824544cdb761 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T05:12:16Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-d5a3a6ac6a5247f4b3b8824544cdb7612023-11-23T00:47:39ZengMDPI AGNutrients2072-66432021-10-011311390210.3390/nu13113902Per- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer ProgressionOzan Berk Imir0Alanna Zoe Kaminsky1Qian-Ying Zuo2Yu-Jeh Liu3Ratnakar Singh4Michael J. Spinella5Joseph Irudayaraj6Wen-Yang Hu7Gail S. Prins8Zeynep Madak Erdogan9Division of Nutritional Sciences, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USADepartment of Food Science and Human Nutrition, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USADepartment of Food Science and Human Nutrition, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USADepartment of Food Science and Human Nutrition, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USAComparative Biosciences, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USAComparative Biosciences, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USACancer Center at Illinois, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USADepartments of Urology, Pathology and Physiology, College of Medicine, University of Illinois Chicago, Chicago, IL 60612, USADepartments of Urology, Pathology and Physiology, College of Medicine, University of Illinois Chicago, Chicago, IL 60612, USADivision of Nutritional Sciences, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USAPer- and polyfluoroalkyl substances (PFAS) are synthetic chemicals utilized in various industrial settings and include products such as flame retardants, artificial film-forming foams, cosmetics, and non-stick cookware, among others. Epidemiological studies suggest a link between increased blood PFAS levels and prostate cancer incidence, but the mechanism through which PFAS impact cancer development is unclear. To investigate the link between PFAS and prostate cancer, we evaluated the impact of metabolic alterations resulting from a high-fat diet combined with PFAS exposure on prostate tumor progression. We evaluated in vivo prostate cancer xenograft models exposed to perfluorooctane sulfonate (PFOS), a type of PFAS compound, and different diets to study the effects of PFAS on prostate cancer progression and metabolic activity. Metabolomics and transcriptomics were used to understand the metabolic landscape shifts upon PFAS exposure. We evaluated metabolic changes in benign or tumor cells that lead to epigenomic reprogramming and altered signaling, which ultimately increase tumorigenic risk and tumor aggressiveness. Our studies are the first in the field to provide new and clinically relevant insights regarding novel metabolic and epigenetic states as well as to support the future development of effective preventative and therapeutic strategies for PFAS-induced prostate cancers. Our findings enhance understanding of how PFAS synergize with high-fat diets to contribute to prostate cancer development and establish an important basis to mitigate PFAS exposure.https://www.mdpi.com/2072-6643/13/11/3902prostate cancerhigh-fat dietPFASmetabolism |
| spellingShingle | Ozan Berk Imir Alanna Zoe Kaminsky Qian-Ying Zuo Yu-Jeh Liu Ratnakar Singh Michael J. Spinella Joseph Irudayaraj Wen-Yang Hu Gail S. Prins Zeynep Madak Erdogan Per- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression Nutrients prostate cancer high-fat diet PFAS metabolism |
| title | Per- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression |
| title_full | Per- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression |
| title_fullStr | Per- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression |
| title_full_unstemmed | Per- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression |
| title_short | Per- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression |
| title_sort | per and polyfluoroalkyl substance exposure combined with high fat diet supports prostate cancer progression |
| topic | prostate cancer high-fat diet PFAS metabolism |
| url | https://www.mdpi.com/2072-6643/13/11/3902 |
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