Prevalence of Intrathecal Acyclovir Resistant Virus in Herpes Simplex Encephalitis Patients.

Prevalence of Intrathecal Acyclovir Resistant Virus in Herpes Simplex Encephalitis Patients.

Herpes simplex encephalitis (HSE) is a life-threatening complication of herpes simplex virus (HSV) infection. Acyclovir (ACV) is the antiviral treatment of choice, but may lead to emergence of ACV-resistant (ACVR) HSV due to mutations in the viral UL23 gene encoding for the ACV-targeted thymidine ki...

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Bibliographic Details
Main Authors:	Johanna G Mitterreiter, Maarten J Titulaer, Gijsbert P van Nierop, Jeroen J A van Kampen, Georgina I Aron, Albert D M E Osterhaus, Georges M G M Verjans, Werner J D Ouwendijk
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2016-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4865163?pdf=render

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