Role of Selective Histone Deacetylase 6 Inhibitor ACY-1215 in Cancer and Other Human Diseases
The deacetylation process regulated by histone deacetylases (HDACs) plays an important role in human health and diseases. HDAC6 belongs to the Class IIb of HDACs family, which mainly modifies non-histone proteins located in the cytoplasm. HDAC6 plays a key role in tumors, neurological diseases, and...
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| Format: | Article |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.907981/full |
| _version_ | 1811200695044407296 |
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| author | Jianglei Li Jianglei Li Meihong Yu Meihong Yu Shifeng Fu Shifeng Fu Deliang Liu Deliang Liu Yuyong Tan Yuyong Tan |
| author_facet | Jianglei Li Jianglei Li Meihong Yu Meihong Yu Shifeng Fu Shifeng Fu Deliang Liu Deliang Liu Yuyong Tan Yuyong Tan |
| author_sort | Jianglei Li |
| collection | DOAJ |
| description | The deacetylation process regulated by histone deacetylases (HDACs) plays an important role in human health and diseases. HDAC6 belongs to the Class IIb of HDACs family, which mainly modifies non-histone proteins located in the cytoplasm. HDAC6 plays a key role in tumors, neurological diseases, and inflammatory diseases. Therefore, targeting HDAC6 has become a promising treatment strategy in recent years. ACY-1215 is the first orally available highly selective HDAC6 inhibitor, and its efficacy and therapeutic effects are being continuously verified. This review summarizes the research progress of ACY-1215 in cancer and other human diseases, as well as the underlying mechanism, in order to guide the future clinical trials of ACY-1215 and more in-depth mechanism researches. |
| first_indexed | 2024-04-12T02:08:21Z |
| format | Article |
| id | doaj.art-d5a8624566a44df2aec9a2d8779e4720 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T02:08:21Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-d5a8624566a44df2aec9a2d8779e47202022-12-22T03:52:29ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-05-011310.3389/fphar.2022.907981907981Role of Selective Histone Deacetylase 6 Inhibitor ACY-1215 in Cancer and Other Human DiseasesJianglei Li0Jianglei Li1Meihong Yu2Meihong Yu3Shifeng Fu4Shifeng Fu5Deliang Liu6Deliang Liu7Yuyong Tan8Yuyong Tan9Department of Gastroenterology, The Second Xiangya Hospital of Central South University, Changsha, ChinaResearch Center of Digestive Disease, Central South University, Changsha, ChinaDepartment of Gastroenterology, The Second Xiangya Hospital of Central South University, Changsha, ChinaResearch Center of Digestive Disease, Central South University, Changsha, ChinaDepartment of Gastroenterology, The Second Xiangya Hospital of Central South University, Changsha, ChinaResearch Center of Digestive Disease, Central South University, Changsha, ChinaDepartment of Gastroenterology, The Second Xiangya Hospital of Central South University, Changsha, ChinaResearch Center of Digestive Disease, Central South University, Changsha, ChinaDepartment of Gastroenterology, The Second Xiangya Hospital of Central South University, Changsha, ChinaResearch Center of Digestive Disease, Central South University, Changsha, ChinaThe deacetylation process regulated by histone deacetylases (HDACs) plays an important role in human health and diseases. HDAC6 belongs to the Class IIb of HDACs family, which mainly modifies non-histone proteins located in the cytoplasm. HDAC6 plays a key role in tumors, neurological diseases, and inflammatory diseases. Therefore, targeting HDAC6 has become a promising treatment strategy in recent years. ACY-1215 is the first orally available highly selective HDAC6 inhibitor, and its efficacy and therapeutic effects are being continuously verified. This review summarizes the research progress of ACY-1215 in cancer and other human diseases, as well as the underlying mechanism, in order to guide the future clinical trials of ACY-1215 and more in-depth mechanism researches.https://www.frontiersin.org/articles/10.3389/fphar.2022.907981/fullhistone deacetylase 6histone deacetylase inhibitorACY-1215cancerneurological diseasesinflammatory diseases |
| spellingShingle | Jianglei Li Jianglei Li Meihong Yu Meihong Yu Shifeng Fu Shifeng Fu Deliang Liu Deliang Liu Yuyong Tan Yuyong Tan Role of Selective Histone Deacetylase 6 Inhibitor ACY-1215 in Cancer and Other Human Diseases Frontiers in Pharmacology histone deacetylase 6 histone deacetylase inhibitor ACY-1215 cancer neurological diseases inflammatory diseases |
| title | Role of Selective Histone Deacetylase 6 Inhibitor ACY-1215 in Cancer and Other Human Diseases |
| title_full | Role of Selective Histone Deacetylase 6 Inhibitor ACY-1215 in Cancer and Other Human Diseases |
| title_fullStr | Role of Selective Histone Deacetylase 6 Inhibitor ACY-1215 in Cancer and Other Human Diseases |
| title_full_unstemmed | Role of Selective Histone Deacetylase 6 Inhibitor ACY-1215 in Cancer and Other Human Diseases |
| title_short | Role of Selective Histone Deacetylase 6 Inhibitor ACY-1215 in Cancer and Other Human Diseases |
| title_sort | role of selective histone deacetylase 6 inhibitor acy 1215 in cancer and other human diseases |
| topic | histone deacetylase 6 histone deacetylase inhibitor ACY-1215 cancer neurological diseases inflammatory diseases |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.907981/full |
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