The intercellular metabolic interplay between tumor and immune cells
Functional and effective immune response requires a metabolic rewiring of immune cells to meet their energetic and anabolic demands. Beyond this, the availability of extracellular and intracellular metabolites may serve as metabolic signals interconnecting with cellular signaling events to influence...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-07-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00358/full |
| _version_ | 1811343595221811200 |
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| author | Tingting eWang Guangwei eLiu Guangwei eLiu Ruoning eWang Ruoning eWang Ruoning eWang |
| author_facet | Tingting eWang Guangwei eLiu Guangwei eLiu Ruoning eWang Ruoning eWang Ruoning eWang |
| author_sort | Tingting eWang |
| collection | DOAJ |
| description | Functional and effective immune response requires a metabolic rewiring of immune cells to meet their energetic and anabolic demands. Beyond this, the availability of extracellular and intracellular metabolites may serve as metabolic signals interconnecting with cellular signaling events to influence cellular fate and immunological function. As such, tumor microenvironment represents a dramatic example of metabolic derangement, where the highly metabolic demanding tumor cells may compromise the function of some immune cells by competing nutrients (a form of intercellular competition), meanwhile may support the function of other immune cells by forming a metabolic symbiosis (a form of intercellular collaboration). It has been well known that tumor cells harness immune system through information exchanges that are largely attributed to soluble protein factors and intercellular junctions. Here, we will review recent advance on tumor metabolism and immune metabolism, provide examples of metabolic communications between tumor cells and immune system, which may represent a novel mechanism of conveying tumor-immune privilege in horizontal manner. |
| first_indexed | 2024-04-13T19:32:44Z |
| format | Article |
| id | doaj.art-d5aa06ed7d1f4ebba6e777c901a005a8 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T19:32:44Z |
| publishDate | 2014-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d5aa06ed7d1f4ebba6e777c901a005a82022-12-22T02:33:09ZengFrontiers Media S.A.Frontiers in Immunology1664-32242014-07-01510.3389/fimmu.2014.00358104730The intercellular metabolic interplay between tumor and immune cellsTingting eWang0Guangwei eLiu1Guangwei eLiu2Ruoning eWang3Ruoning eWang4Ruoning eWang5Center for Childhood Cancer and Blood Disease, The Research Institute at Nationwide Children's HospitalFudan University School of Basic Medical SciencesFudan UniversityCenter for Childhood Cancer and Blood Disease, The Research Institute at Nationwide Children's HospitalHematology/Oncology & BMT, The Research Institute at Nationwide Children's HospitalThe Ohio State University School of MedicineFunctional and effective immune response requires a metabolic rewiring of immune cells to meet their energetic and anabolic demands. Beyond this, the availability of extracellular and intracellular metabolites may serve as metabolic signals interconnecting with cellular signaling events to influence cellular fate and immunological function. As such, tumor microenvironment represents a dramatic example of metabolic derangement, where the highly metabolic demanding tumor cells may compromise the function of some immune cells by competing nutrients (a form of intercellular competition), meanwhile may support the function of other immune cells by forming a metabolic symbiosis (a form of intercellular collaboration). It has been well known that tumor cells harness immune system through information exchanges that are largely attributed to soluble protein factors and intercellular junctions. Here, we will review recent advance on tumor metabolism and immune metabolism, provide examples of metabolic communications between tumor cells and immune system, which may represent a novel mechanism of conveying tumor-immune privilege in horizontal manner.http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00358/fullMetabolismSymbiosistumortumor immunityAntagonism |
| spellingShingle | Tingting eWang Guangwei eLiu Guangwei eLiu Ruoning eWang Ruoning eWang Ruoning eWang The intercellular metabolic interplay between tumor and immune cells Frontiers in Immunology Metabolism Symbiosis tumor tumor immunity Antagonism |
| title | The intercellular metabolic interplay between tumor and immune cells |
| title_full | The intercellular metabolic interplay between tumor and immune cells |
| title_fullStr | The intercellular metabolic interplay between tumor and immune cells |
| title_full_unstemmed | The intercellular metabolic interplay between tumor and immune cells |
| title_short | The intercellular metabolic interplay between tumor and immune cells |
| title_sort | intercellular metabolic interplay between tumor and immune cells |
| topic | Metabolism Symbiosis tumor tumor immunity Antagonism |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00358/full |
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