Hepatitis B, C and D virus infections and risk of hepatocellular carcinoma in Africa: A meta-analysis including sensitivity analyses for studies comparable for confounders.
<h4>Introduction</h4>Africa denotes unique facies for hepatocellular carcinoma (HCC) characterized by a conjunction of low sensitization, restricted access to diagnosis and treatment and associated with the highest incidence and mortality in the world. We investigated whether hepatitis B...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0262903 |
| _version_ | 1818473391005368320 |
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| author | Donatien Serge Mbaga Sebastien Kenmoe Cyprien Kengne-Ndé Jean Thierry Ebogo-Belobo Gadji Mahamat Joseph Rodrigue Foe-Essomba Marie Amougou-Atsama Serges Tchatchouang Inès Nyebe Alfloditte Flore Feudjio Ginette Irma Kame-Ngasse Jeannette Nina Magoudjou-Pekam Lorraine K M Fokou Dowbiss Meta-Djomsi Martin Maïdadi-Foudi Sabine Aimee Touangnou-Chamda Audrey Gaelle Daha-Tchoffo Abdel Aziz Selly-Ngaloumo Rachel Audrey Nayang-Mundo Jacqueline Félicité Yéngué Jean Bosco Taya-Fokou Raoul Kenfack-Momo Efietngab Atembeh Noura Cynthia Paola Demeni Emoh Hervé Raoul Tazokong Arnol Bowo-Ngandji Carole Stéphanie Sake Etienne Atenguena Okobalemba Jacky Njiki Bikoi Richard Njouom Sara Honorine Riwom Essama |
| author_facet | Donatien Serge Mbaga Sebastien Kenmoe Cyprien Kengne-Ndé Jean Thierry Ebogo-Belobo Gadji Mahamat Joseph Rodrigue Foe-Essomba Marie Amougou-Atsama Serges Tchatchouang Inès Nyebe Alfloditte Flore Feudjio Ginette Irma Kame-Ngasse Jeannette Nina Magoudjou-Pekam Lorraine K M Fokou Dowbiss Meta-Djomsi Martin Maïdadi-Foudi Sabine Aimee Touangnou-Chamda Audrey Gaelle Daha-Tchoffo Abdel Aziz Selly-Ngaloumo Rachel Audrey Nayang-Mundo Jacqueline Félicité Yéngué Jean Bosco Taya-Fokou Raoul Kenfack-Momo Efietngab Atembeh Noura Cynthia Paola Demeni Emoh Hervé Raoul Tazokong Arnol Bowo-Ngandji Carole Stéphanie Sake Etienne Atenguena Okobalemba Jacky Njiki Bikoi Richard Njouom Sara Honorine Riwom Essama |
| author_sort | Donatien Serge Mbaga |
| collection | DOAJ |
| description | <h4>Introduction</h4>Africa denotes unique facies for hepatocellular carcinoma (HCC) characterized by a conjunction of low sensitization, restricted access to diagnosis and treatment and associated with the highest incidence and mortality in the world. We investigated whether hepatitis B (HBV), C (HCV) and D (VHD) viruses were etiological agents of HCC in Africa.<h4>Methods</h4>Relevant articles were searched in PubMed, Web of Science, African Index Medicus, and African Journal Online databases, as well as manual searches in relevant reviews and included articles. Analytical studies from Africa evaluating the association between HCC development and HBV, HCV, and HDV were included. Relevant studies were selected, data extracted, and the risk of bias assessed independently by at least 2 investigators. The association was estimated using odds ratios (OR) and their 95% confidence interval (95% CI) determined by a random-effects model. Sources of heterogeneity were determined by subgroup analyses.<h4>Results</h4>A total of 36 case-control studies were included. With controls having non-hepatic disease, the overall results suggested a significantly increased risk of HCC in patients with HBV (HBeAg (OR = 19.9; 95% CI = [3.7-105.2]), HBsAg (OR = 9.9; 95%) CI = [6.2-15.6]) and DNA (OR = 8.9; 95% CI = [5.9-13.4]); HCV (Anti-HCV (OR = 9.4; 95% CI = [6.3-14.0]) and RNA (OR = 16.5; 95% CI = [7.8-34.6]); HDV (Anti-VHD, (OR = 25.8; 95% CI = [5.9-112.2]); and HBV/HCV coinfections (HBV DNA/HCV RNA (OR = 22.5; 95% CI = [1.3-387.8]). With apparently healthy controls, the overall results suggested a significantly increased risk of HCC in patients with HBV (HBsAg, (OR = 8.9; 95% CI = [6.0-13.0]); HCV (Anti-HCV, (OR = 7.7; 95% CI = [5.6-10.6]); and HBV/HCV coinfections (HBsAg/Anti-HCV (OR = 7.8; 95% CI = [4.4-13.6]) Substantial heterogeneity and the absence of publication bias were recorded for these results.<h4>Conclusions</h4>In Africa, HBV/HCV coinfections and HBV, HCV, and HDV infections are associated with an increased risk of developing HCC. The implementation of large-scale longitudinal and prospective studies including healthy participants to search for early biomarkers of the risk of progression to HCC is urgently needed. |
| first_indexed | 2024-04-14T04:23:22Z |
| format | Article |
| id | doaj.art-d5aaaae89b4b429b9418ae452b85a1a8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-14T04:23:22Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d5aaaae89b4b429b9418ae452b85a1a82022-12-22T02:12:26ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01171e026290310.1371/journal.pone.0262903Hepatitis B, C and D virus infections and risk of hepatocellular carcinoma in Africa: A meta-analysis including sensitivity analyses for studies comparable for confounders.Donatien Serge MbagaSebastien KenmoeCyprien Kengne-NdéJean Thierry Ebogo-BeloboGadji MahamatJoseph Rodrigue Foe-EssombaMarie Amougou-AtsamaSerges TchatchouangInès NyebeAlfloditte Flore FeudjioGinette Irma Kame-NgasseJeannette Nina Magoudjou-PekamLorraine K M FokouDowbiss Meta-DjomsiMartin Maïdadi-FoudiSabine Aimee Touangnou-ChamdaAudrey Gaelle Daha-TchoffoAbdel Aziz Selly-NgaloumoRachel Audrey Nayang-MundoJacqueline Félicité YénguéJean Bosco Taya-FokouRaoul Kenfack-MomoEfietngab Atembeh NouraCynthia Paola Demeni EmohHervé Raoul TazokongArnol Bowo-NgandjiCarole Stéphanie SakeEtienne Atenguena OkobalembaJacky Njiki BikoiRichard NjouomSara Honorine Riwom Essama<h4>Introduction</h4>Africa denotes unique facies for hepatocellular carcinoma (HCC) characterized by a conjunction of low sensitization, restricted access to diagnosis and treatment and associated with the highest incidence and mortality in the world. We investigated whether hepatitis B (HBV), C (HCV) and D (VHD) viruses were etiological agents of HCC in Africa.<h4>Methods</h4>Relevant articles were searched in PubMed, Web of Science, African Index Medicus, and African Journal Online databases, as well as manual searches in relevant reviews and included articles. Analytical studies from Africa evaluating the association between HCC development and HBV, HCV, and HDV were included. Relevant studies were selected, data extracted, and the risk of bias assessed independently by at least 2 investigators. The association was estimated using odds ratios (OR) and their 95% confidence interval (95% CI) determined by a random-effects model. Sources of heterogeneity were determined by subgroup analyses.<h4>Results</h4>A total of 36 case-control studies were included. With controls having non-hepatic disease, the overall results suggested a significantly increased risk of HCC in patients with HBV (HBeAg (OR = 19.9; 95% CI = [3.7-105.2]), HBsAg (OR = 9.9; 95%) CI = [6.2-15.6]) and DNA (OR = 8.9; 95% CI = [5.9-13.4]); HCV (Anti-HCV (OR = 9.4; 95% CI = [6.3-14.0]) and RNA (OR = 16.5; 95% CI = [7.8-34.6]); HDV (Anti-VHD, (OR = 25.8; 95% CI = [5.9-112.2]); and HBV/HCV coinfections (HBV DNA/HCV RNA (OR = 22.5; 95% CI = [1.3-387.8]). With apparently healthy controls, the overall results suggested a significantly increased risk of HCC in patients with HBV (HBsAg, (OR = 8.9; 95% CI = [6.0-13.0]); HCV (Anti-HCV, (OR = 7.7; 95% CI = [5.6-10.6]); and HBV/HCV coinfections (HBsAg/Anti-HCV (OR = 7.8; 95% CI = [4.4-13.6]) Substantial heterogeneity and the absence of publication bias were recorded for these results.<h4>Conclusions</h4>In Africa, HBV/HCV coinfections and HBV, HCV, and HDV infections are associated with an increased risk of developing HCC. The implementation of large-scale longitudinal and prospective studies including healthy participants to search for early biomarkers of the risk of progression to HCC is urgently needed.https://doi.org/10.1371/journal.pone.0262903 |
| spellingShingle | Donatien Serge Mbaga Sebastien Kenmoe Cyprien Kengne-Ndé Jean Thierry Ebogo-Belobo Gadji Mahamat Joseph Rodrigue Foe-Essomba Marie Amougou-Atsama Serges Tchatchouang Inès Nyebe Alfloditte Flore Feudjio Ginette Irma Kame-Ngasse Jeannette Nina Magoudjou-Pekam Lorraine K M Fokou Dowbiss Meta-Djomsi Martin Maïdadi-Foudi Sabine Aimee Touangnou-Chamda Audrey Gaelle Daha-Tchoffo Abdel Aziz Selly-Ngaloumo Rachel Audrey Nayang-Mundo Jacqueline Félicité Yéngué Jean Bosco Taya-Fokou Raoul Kenfack-Momo Efietngab Atembeh Noura Cynthia Paola Demeni Emoh Hervé Raoul Tazokong Arnol Bowo-Ngandji Carole Stéphanie Sake Etienne Atenguena Okobalemba Jacky Njiki Bikoi Richard Njouom Sara Honorine Riwom Essama Hepatitis B, C and D virus infections and risk of hepatocellular carcinoma in Africa: A meta-analysis including sensitivity analyses for studies comparable for confounders. PLoS ONE |
| title | Hepatitis B, C and D virus infections and risk of hepatocellular carcinoma in Africa: A meta-analysis including sensitivity analyses for studies comparable for confounders. |
| title_full | Hepatitis B, C and D virus infections and risk of hepatocellular carcinoma in Africa: A meta-analysis including sensitivity analyses for studies comparable for confounders. |
| title_fullStr | Hepatitis B, C and D virus infections and risk of hepatocellular carcinoma in Africa: A meta-analysis including sensitivity analyses for studies comparable for confounders. |
| title_full_unstemmed | Hepatitis B, C and D virus infections and risk of hepatocellular carcinoma in Africa: A meta-analysis including sensitivity analyses for studies comparable for confounders. |
| title_short | Hepatitis B, C and D virus infections and risk of hepatocellular carcinoma in Africa: A meta-analysis including sensitivity analyses for studies comparable for confounders. |
| title_sort | hepatitis b c and d virus infections and risk of hepatocellular carcinoma in africa a meta analysis including sensitivity analyses for studies comparable for confounders |
| url | https://doi.org/10.1371/journal.pone.0262903 |
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