Asparagine Deprivation Causes a Reversible Inhibition of Human Cytomegalovirus Acute Virus Replication

Asparagine Deprivation Causes a Reversible Inhibition of Human Cytomegalovirus Acute Virus Replication

ABSTRACT As obligate intracellular pathogens, viruses rely on the host cell machinery to replicate efficiently, with the host metabolism extensively manipulated for this purpose. High-throughput small interfering RNA (siRNA) screens provide a systematic approach for the identification of novel host-...

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Bibliographic Details
Main Authors: Chen-Hsuin Lee, Samantha Griffiths, Paul Digard, Nhan Pham, Manfred Auer, Juergen Haas, Finn Grey
Format: Article
Language:English
Published: American Society for Microbiology 2019-10-01
Series:mBio
Subjects:
asparagine
human cytomegalovirus
latency
antiviral
high throughput
siRNA screen
Online Access:https://journals.asm.org/doi/10.1128/mBio.01651-19

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