Development and optimization of dispersible tablet of Bacopa monnieri with improved functionality for memory enhancement
Introduction: The Bacopa monnieri is traditional Ayurvedic medicine, and reported for memory-enhancing effects. The Bacoside is poorly soluble, bitter in taste and responsible for the memory enhancement action. Memory enhancer is commonly prescribed for children or elder people. Objective: Poor solu...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2017;volume=9;issue=3;spage=208;epage=215;aulast=Thakkar |
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| author | Vaishali Tejas Thakkar Amol Deshmukh Lal Hingorani Payal Juneja Lalji Baldaniya Asha Patel Tosha Pandya Mukesh Gohel |
| author_facet | Vaishali Tejas Thakkar Amol Deshmukh Lal Hingorani Payal Juneja Lalji Baldaniya Asha Patel Tosha Pandya Mukesh Gohel |
| author_sort | Vaishali Tejas Thakkar |
| collection | DOAJ |
| description | Introduction: The Bacopa monnieri is traditional Ayurvedic medicine, and reported for memory-enhancing effects. The Bacoside is poorly soluble, bitter in taste and responsible for the memory enhancement action. Memory enhancer is commonly prescribed for children or elder people. Objective: Poor solubility, patient compliance and bitterness were a major driving force to develop taste masked β-cyclodextrin complex and dispersible tablets. Materials and Methods: The inclusion complex of Bacopa monnieri and β-cyclodextrin was prepared in different molar ratios of Bacopa monnieri by Co-precipitation method. Phase solubility study was conducted to evaluate the effect of β-cyclodextrin on aqueous solubility of Bacoside A. The characterization was determined by Fourier transformation infrared spectroscopy (FTIR),Differential scanning calorimetry (DSC) and X-ray diffraction study (XRD).Crospovidone and croscarmallose sodium were used as super disintigrant.The 32 full factorial design was adopted to investigate the influence of two superdisintegrants on the wetting time and disntegration time of the tablets. Conclusion: The result revels that molar ratio (1:4) of inclusion complex enhance 3-fold solubility. Full factorial design was successfully employed for the optimization of dispersible tablet of B. monnieri . The short-term accelerated stability study confirmed that high stability of B. monnieri in inclusion complex. |
| first_indexed | 2024-12-11T19:07:09Z |
| format | Article |
| id | doaj.art-d5aad8f38506422ba0270e414f34fb33 |
| institution | Directory Open Access Journal |
| issn | 0975-7406 |
| language | English |
| last_indexed | 2024-12-11T19:07:09Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj.art-d5aad8f38506422ba0270e414f34fb332022-12-22T00:53:52ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0975-74062017-01-019320821510.4103/jpbs.JPBS_8_17Development and optimization of dispersible tablet of Bacopa monnieri with improved functionality for memory enhancementVaishali Tejas ThakkarAmol DeshmukhLal HingoraniPayal JunejaLalji BaldaniyaAsha PatelTosha PandyaMukesh GohelIntroduction: The Bacopa monnieri is traditional Ayurvedic medicine, and reported for memory-enhancing effects. The Bacoside is poorly soluble, bitter in taste and responsible for the memory enhancement action. Memory enhancer is commonly prescribed for children or elder people. Objective: Poor solubility, patient compliance and bitterness were a major driving force to develop taste masked β-cyclodextrin complex and dispersible tablets. Materials and Methods: The inclusion complex of Bacopa monnieri and β-cyclodextrin was prepared in different molar ratios of Bacopa monnieri by Co-precipitation method. Phase solubility study was conducted to evaluate the effect of β-cyclodextrin on aqueous solubility of Bacoside A. The characterization was determined by Fourier transformation infrared spectroscopy (FTIR),Differential scanning calorimetry (DSC) and X-ray diffraction study (XRD).Crospovidone and croscarmallose sodium were used as super disintigrant.The 32 full factorial design was adopted to investigate the influence of two superdisintegrants on the wetting time and disntegration time of the tablets. Conclusion: The result revels that molar ratio (1:4) of inclusion complex enhance 3-fold solubility. Full factorial design was successfully employed for the optimization of dispersible tablet of B. monnieri . The short-term accelerated stability study confirmed that high stability of B. monnieri in inclusion complex.http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2017;volume=9;issue=3;spage=208;epage=215;aulast=ThakkarBacopa monnieridispersible tabletmemory enhancerβ-cyclodextrin |
| spellingShingle | Vaishali Tejas Thakkar Amol Deshmukh Lal Hingorani Payal Juneja Lalji Baldaniya Asha Patel Tosha Pandya Mukesh Gohel Development and optimization of dispersible tablet of Bacopa monnieri with improved functionality for memory enhancement Journal of Pharmacy and Bioallied Sciences Bacopa monnieri dispersible tablet memory enhancer β-cyclodextrin |
| title | Development and optimization of dispersible tablet of Bacopa monnieri with improved functionality for memory enhancement |
| title_full | Development and optimization of dispersible tablet of Bacopa monnieri with improved functionality for memory enhancement |
| title_fullStr | Development and optimization of dispersible tablet of Bacopa monnieri with improved functionality for memory enhancement |
| title_full_unstemmed | Development and optimization of dispersible tablet of Bacopa monnieri with improved functionality for memory enhancement |
| title_short | Development and optimization of dispersible tablet of Bacopa monnieri with improved functionality for memory enhancement |
| title_sort | development and optimization of dispersible tablet of bacopa monnieri with improved functionality for memory enhancement |
| topic | Bacopa monnieri dispersible tablet memory enhancer β-cyclodextrin |
| url | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2017;volume=9;issue=3;spage=208;epage=215;aulast=Thakkar |
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