Study of various groups of regulatory molecules during pregnancy against the background of chronic pyelonephritis
The presence of infectious inflammatory process in a pregnant woman can lead to a disorder in the “mother – placenta – fetus” system.Aim of the study was to investigate the level of regulatory and pro-inflammatory molecules in pregnancy occurring against the background of chronic pyelonephritis with...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Siberian Branch Publishing House
2024-01-01
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| Series: | Сибирский научный медицинский журнал |
| Subjects: | |
| Online Access: | https://sibmed.elpub.ru/jour/article/view/1328 |
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| author | V. I. Shcherbakov O. O. Obukhova T. I. Ryabichenko G. A. Skosyreva O. M. Gorbenko T. G. Kosyanova |
| author_facet | V. I. Shcherbakov O. O. Obukhova T. I. Ryabichenko G. A. Skosyreva O. M. Gorbenko T. G. Kosyanova |
| author_sort | V. I. Shcherbakov |
| collection | DOAJ |
| description | The presence of infectious inflammatory process in a pregnant woman can lead to a disorder in the “mother – placenta – fetus” system.Aim of the study was to investigate the level of regulatory and pro-inflammatory molecules in pregnancy occurring against the background of chronic pyelonephritis without exacerbation.Material and methods. The concentration of IL-17A, monocytic chemotactic protein-1 (MCP-1), vascular endothelial growth factor (VEGF), and IgG autoantibodies to double-stranded DNA (AAT to nDNA) was determined in the blood serum of pregnant women with a gestation period of 36–40 weeks using ELISA.Results. It has been shown that in the third trimester of pregnancy occurring against the background of chronic pyelonephritis without exacerbation, compared with a normal pregnancy, the level of MHP-1 and IL-17A increases, the content of VEGF decreases, and the concentration of AAT to nDNA does not change significantly. An increase in the proinflammatory cytokine IL17A and a decrease in VEGF level can lead to intrauterine fetal growth retardation due to inhibition of amino acid transporters in the placenta.Conclusions. In pregnancy occurring against the background of chronic pyelonephritis without exacerbation, a change in the level of IL17A, MСP-1, VEGF can have a significant impact on the course of pregnancy. |
| first_indexed | 2024-03-08T14:33:26Z |
| format | Article |
| id | doaj.art-d5ad2b0d02114fcbb25b3dbdcc602190 |
| institution | Directory Open Access Journal |
| issn | 2410-2512 2410-2520 |
| language | Russian |
| last_indexed | 2025-03-14T13:19:16Z |
| publishDate | 2024-01-01 |
| publisher | Russian Academy of Sciences, Siberian Branch Publishing House |
| record_format | Article |
| series | Сибирский научный медицинский журнал |
| spelling | doaj.art-d5ad2b0d02114fcbb25b3dbdcc6021902025-02-28T13:43:59ZrusRussian Academy of Sciences, Siberian Branch Publishing HouseСибирский научный медицинский журнал2410-25122410-25202024-01-0143621021410.18699/SSMJ20230626578Study of various groups of regulatory molecules during pregnancy against the background of chronic pyelonephritisV. I. Shcherbakov0O. O. Obukhova1T. I. Ryabichenko2G. A. Skosyreva3O. M. Gorbenko4T. G. Kosyanova5Federal Research Center of Fundamental and Translational MedicineFederal Research Center of Fundamental and Translational MedicineFederal Research Center of Fundamental and Translational MedicineFederal Research Center of Fundamental and Translational MedicineFederal Research Center of Fundamental and Translational MedicineFederal Research Center of Fundamental and Translational MedicineThe presence of infectious inflammatory process in a pregnant woman can lead to a disorder in the “mother – placenta – fetus” system.Aim of the study was to investigate the level of regulatory and pro-inflammatory molecules in pregnancy occurring against the background of chronic pyelonephritis without exacerbation.Material and methods. The concentration of IL-17A, monocytic chemotactic protein-1 (MCP-1), vascular endothelial growth factor (VEGF), and IgG autoantibodies to double-stranded DNA (AAT to nDNA) was determined in the blood serum of pregnant women with a gestation period of 36–40 weeks using ELISA.Results. It has been shown that in the third trimester of pregnancy occurring against the background of chronic pyelonephritis without exacerbation, compared with a normal pregnancy, the level of MHP-1 and IL-17A increases, the content of VEGF decreases, and the concentration of AAT to nDNA does not change significantly. An increase in the proinflammatory cytokine IL17A and a decrease in VEGF level can lead to intrauterine fetal growth retardation due to inhibition of amino acid transporters in the placenta.Conclusions. In pregnancy occurring against the background of chronic pyelonephritis without exacerbation, a change in the level of IL17A, MСP-1, VEGF can have a significant impact on the course of pregnancy.https://sibmed.elpub.ru/jour/article/view/1328pregnancypyelonephritisimmune systemcytokines |
| spellingShingle | V. I. Shcherbakov O. O. Obukhova T. I. Ryabichenko G. A. Skosyreva O. M. Gorbenko T. G. Kosyanova Study of various groups of regulatory molecules during pregnancy against the background of chronic pyelonephritis Сибирский научный медицинский журнал pregnancy pyelonephritis immune system cytokines |
| title | Study of various groups of regulatory molecules during pregnancy against the background of chronic pyelonephritis |
| title_full | Study of various groups of regulatory molecules during pregnancy against the background of chronic pyelonephritis |
| title_fullStr | Study of various groups of regulatory molecules during pregnancy against the background of chronic pyelonephritis |
| title_full_unstemmed | Study of various groups of regulatory molecules during pregnancy against the background of chronic pyelonephritis |
| title_short | Study of various groups of regulatory molecules during pregnancy against the background of chronic pyelonephritis |
| title_sort | study of various groups of regulatory molecules during pregnancy against the background of chronic pyelonephritis |
| topic | pregnancy pyelonephritis immune system cytokines |
| url | https://sibmed.elpub.ru/jour/article/view/1328 |
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