Levels of serum antibodies to enterobacterial lipopolysaccharides and their relationship with concentration of C-reactive protein in diabetes mellitus patients
We examined patients with type 1 (DM 1) and type 2 (DM 2) diabetes mellitus. The concentration of C-reactive protein (CRP) in the blood and levels of serum antibodies to different classes of enterobacterial lipopolysaccharides (LPS) were determined by ELISA. Using cluster analysis it was shown that...
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| Format: | Article |
| Language: | English |
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National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2015-06-01
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| Series: | The Ukrainian Biochemical Journal |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2015/07/Gordienko_3_15.pdf |
| _version_ | 1797428340225736704 |
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| author | A. I. Gordienko |
| author_facet | A. I. Gordienko |
| author_sort | A. I. Gordienko |
| collection | DOAJ |
| description | We examined patients with type 1 (DM 1) and type 2 (DM 2) diabetes mellitus. The concentration of C-reactive protein (CRP) in the blood and levels of serum antibodies to different classes of enterobacterial lipopolysaccharides (LPS) were determined by ELISA. Using cluster analysis it was shown that in 40.8% DM-1 patients the increased concentration of CRP is associated with a decrease in the levels of serum anti-LPS-IgA, anti-LPS-IgM and anti-LPS-IgG. In 56.7% of DM-2 patients with increased concentration of CRP levels of serum anti-LPS-IgA and anti-LPS-IgM were not significantly different from the normal values, but the levels of serum anti-LPS-IgG were significantly increased. Activation of inflammation and increase of concentration of the CRP in the blood of DM-2 patients is accompanied by a significant increase in the levels of serum anti-LPS-A and anti-LPS-G, as well as the tendency to reduce the levels of anti-LPS-IgM. The results of this study suggest an association between low intensity inflammation and immune response to enterobacterial LPS in type 1 and 2 diabetes mellitus. |
| first_indexed | 2024-03-09T08:56:37Z |
| format | Article |
| id | doaj.art-d5ae71a7b6f943ff892511bd9bcb605e |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-09T08:56:37Z |
| publishDate | 2015-06-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-d5ae71a7b6f943ff892511bd9bcb605e2023-12-02T12:56:56ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032015-06-018739810610.15407/ubj87.03.098Levels of serum antibodies to enterobacterial lipopolysaccharides and their relationship with concentration of C-reactive protein in diabetes mellitus patientsA. I. Gordienko0S. I. Georgievsky Crimea state medical university, SimferopolWe examined patients with type 1 (DM 1) and type 2 (DM 2) diabetes mellitus. The concentration of C-reactive protein (CRP) in the blood and levels of serum antibodies to different classes of enterobacterial lipopolysaccharides (LPS) were determined by ELISA. Using cluster analysis it was shown that in 40.8% DM-1 patients the increased concentration of CRP is associated with a decrease in the levels of serum anti-LPS-IgA, anti-LPS-IgM and anti-LPS-IgG. In 56.7% of DM-2 patients with increased concentration of CRP levels of serum anti-LPS-IgA and anti-LPS-IgM were not significantly different from the normal values, but the levels of serum anti-LPS-IgG were significantly increased. Activation of inflammation and increase of concentration of the CRP in the blood of DM-2 patients is accompanied by a significant increase in the levels of serum anti-LPS-A and anti-LPS-G, as well as the tendency to reduce the levels of anti-LPS-IgM. The results of this study suggest an association between low intensity inflammation and immune response to enterobacterial LPS in type 1 and 2 diabetes mellitus.http://ukrbiochemjournal.org/wp-content/uploads/2015/07/Gordienko_3_15.pdf |
| spellingShingle | A. I. Gordienko Levels of serum antibodies to enterobacterial lipopolysaccharides and their relationship with concentration of C-reactive protein in diabetes mellitus patients The Ukrainian Biochemical Journal |
| title | Levels of serum antibodies to enterobacterial lipopolysaccharides and their relationship with concentration of C-reactive protein in diabetes mellitus patients |
| title_full | Levels of serum antibodies to enterobacterial lipopolysaccharides and their relationship with concentration of C-reactive protein in diabetes mellitus patients |
| title_fullStr | Levels of serum antibodies to enterobacterial lipopolysaccharides and their relationship with concentration of C-reactive protein in diabetes mellitus patients |
| title_full_unstemmed | Levels of serum antibodies to enterobacterial lipopolysaccharides and their relationship with concentration of C-reactive protein in diabetes mellitus patients |
| title_short | Levels of serum antibodies to enterobacterial lipopolysaccharides and their relationship with concentration of C-reactive protein in diabetes mellitus patients |
| title_sort | levels of serum antibodies to enterobacterial lipopolysaccharides and their relationship with concentration of c reactive protein in diabetes mellitus patients |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2015/07/Gordienko_3_15.pdf |
| work_keys_str_mv | AT aigordienko levelsofserumantibodiestoenterobacteriallipopolysaccharidesandtheirrelationshipwithconcentrationofcreactiveproteinindiabetesmellituspatients |