Advances in fecal microbiota transplantation for the treatment of diabetes mellitus
Diabetes mellitus (DM) refers to a group of chronic diseases with global prevalence, characterized by persistent hyperglycemia resulting from various etiologies. DM can harm various organ systems and lead to acute or chronic complications, which severely endanger human well-being. Traditional treatm...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1370999/full |
| _version_ | 1797215854427897856 |
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| author | Juan Zhang Honggang Wang Ying Liu Min Shi Minna Zhang Hong Zhang Juan Chen |
| author_facet | Juan Zhang Honggang Wang Ying Liu Min Shi Minna Zhang Hong Zhang Juan Chen |
| author_sort | Juan Zhang |
| collection | DOAJ |
| description | Diabetes mellitus (DM) refers to a group of chronic diseases with global prevalence, characterized by persistent hyperglycemia resulting from various etiologies. DM can harm various organ systems and lead to acute or chronic complications, which severely endanger human well-being. Traditional treatment mainly involves controlling blood sugar levels through replacement therapy with drugs and insulin; however, some patients still find a satisfactory curative effect difficult to achieve. Extensive research has demonstrated a close correlation between enteric dysbacteriosis and the pathogenesis of various types of DM, paving the way for novel therapeutic approaches targeting the gut microbiota to manage DM. Fecal microbiota transplantation (FMT), a method for re-establishing the intestinal microbiome balance, offers new possibilities for treating diabetes. This article provides a comprehensive review of the correlation between DM and the gut microbiota, as well as the current advancements in FMT treatment for DM, using FMT as an illustrative example. This study aims to offer novel perspectives and establish a theoretical foundation for the clinical diagnosis and management of DM. |
| first_indexed | 2024-04-24T11:36:41Z |
| format | Article |
| id | doaj.art-d5af1613064b461ab487870634131d49 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-24T11:36:41Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-d5af1613064b461ab487870634131d492024-04-10T05:09:33ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882024-04-011410.3389/fcimb.2024.13709991370999Advances in fecal microbiota transplantation for the treatment of diabetes mellitusJuan Zhang0Honggang Wang1Ying Liu2Min Shi3Minna Zhang4Hong Zhang5Juan Chen6Department of Endocrinology, the Affiliated Huai’an No.1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu, ChinaDepartment of Gastroenterology, the Affiliated Huai’an No.1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu, ChinaDepartment of Endocrinology, the Affiliated Huai’an No.1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu, ChinaDepartment of Endocrinology, the Affiliated Huai’an No.1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu, ChinaDepartment of Gastroenterology, the Affiliated Huai’an No.1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu, ChinaDepartment of Endocrinology, the Affiliated Huai’an No.1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu, ChinaDepartment of Endocrinology, the Affiliated Huai’an No.1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu, ChinaDiabetes mellitus (DM) refers to a group of chronic diseases with global prevalence, characterized by persistent hyperglycemia resulting from various etiologies. DM can harm various organ systems and lead to acute or chronic complications, which severely endanger human well-being. Traditional treatment mainly involves controlling blood sugar levels through replacement therapy with drugs and insulin; however, some patients still find a satisfactory curative effect difficult to achieve. Extensive research has demonstrated a close correlation between enteric dysbacteriosis and the pathogenesis of various types of DM, paving the way for novel therapeutic approaches targeting the gut microbiota to manage DM. Fecal microbiota transplantation (FMT), a method for re-establishing the intestinal microbiome balance, offers new possibilities for treating diabetes. This article provides a comprehensive review of the correlation between DM and the gut microbiota, as well as the current advancements in FMT treatment for DM, using FMT as an illustrative example. This study aims to offer novel perspectives and establish a theoretical foundation for the clinical diagnosis and management of DM.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1370999/fullfecal microbiota transplantationdiabetes mellitusdiabetes complicationsgastrointestinal microbiomemetabolitemetabolic disease |
| spellingShingle | Juan Zhang Honggang Wang Ying Liu Min Shi Minna Zhang Hong Zhang Juan Chen Advances in fecal microbiota transplantation for the treatment of diabetes mellitus Frontiers in Cellular and Infection Microbiology fecal microbiota transplantation diabetes mellitus diabetes complications gastrointestinal microbiome metabolite metabolic disease |
| title | Advances in fecal microbiota transplantation for the treatment of diabetes mellitus |
| title_full | Advances in fecal microbiota transplantation for the treatment of diabetes mellitus |
| title_fullStr | Advances in fecal microbiota transplantation for the treatment of diabetes mellitus |
| title_full_unstemmed | Advances in fecal microbiota transplantation for the treatment of diabetes mellitus |
| title_short | Advances in fecal microbiota transplantation for the treatment of diabetes mellitus |
| title_sort | advances in fecal microbiota transplantation for the treatment of diabetes mellitus |
| topic | fecal microbiota transplantation diabetes mellitus diabetes complications gastrointestinal microbiome metabolite metabolic disease |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1370999/full |
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